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A total of 3,372 people were surveyed from large cities in China, of whom 1,572 were males and 1,800 were females (including 78 pregnant women), accounting for 46.6% and 53.4%, respectively. Among them, detailed population samples were mainly divided into five subgroups. The age, sex grouping of the participants, and hsCRP concentration (mg/L) for population in large cities were shown in Table 1. The percentile distribution of hsCRP for population in large cities (mg/L) is shown inTable 2.
Age (years) Male Female Total ${{\rm{\bar {\text{X}}}}_{\text{G}}}$ 95% CI ${{\rm{\bar {\text{X}}}}_{\text{G}}}$ 95% CI ${{\rm{\bar {\text{X}}}}_{\text{G}}}$ 95% CI Total 0.68 0.64–0.72 0.65 0.62–0.69 0.67 0.64–0.70 6–11 0.34 0.30–0.40 0.34 0.29–0.40 0.34 0.31–0.38 12–17 0.37 0.32–0.43 0.30 0.26–0.34 0.33 0.30–0.37 18–44 0.74 0.66–0.83 0.54 0.48–0.59 0.62 0.57–0.67 45–59 0.91 0.81–1.02 0.94 0.85–1.06 0.93 0.86–1.00 ≥ 60 1.05 0.93–1.18 1.14 1.02–1.26 1.09 1.01–1.18 Pregnant 1.42 1.16–1.73 1.42 1.16–1.73 Table 1. hsCRP concentration for population in large cities (mg/L)
Age (years) n P2.5 P5 P10 P25 P50 P75 P90 P95 P97.5 Total Subtotal 3,372 0.10 0.13 0.16 0.27 0.59 1.43 3.35 5.48 9.32 6–11 489 0.08 0.09 0.11 0.16 0.26 0.58 1.92 4.00 7.16 12–17 463 0.08 0.10 0.12 0.16 0.25 0.51 1.56 3.22 6.36 18–44 774 0.11 0.15 0.19 0.28 0.52 1.20 2.65 4.70 6.42 45–59 779 0.15 0.19 0.26 0.42 0.82 1.72 3.92 6.37 16.42 ≥ 60 789 0.17 0.22 0.29 0.49 0.98 2.22 4.66 8.50 13.79 Pregnant 78 0.18 0.29 0.41 0.74 1.50 2.59 4.22 6.66 7.86 Male 6–11 241 0.08 0.09 0.12 0.16 0.26 0.62 1.90 3.59 6.54 12–17 227 0.07 0.11 0.13 0.17 0.28 0.61 1.96 4.20 6.53 18–44 349 0.15 0.18 0.21 0.32 0.65 1.56 3.17 5.05 6.14 45–59 364 0.16 0.19 0.28 0.41 0.81 1.84 3.92 5.60 12.10 ≥ 60 391 0.18 0.21 0.27 0.43 0.93 2.08 4.76 9.00 19.18 Subtotall 1,572 0.10 0.14 0.17 0.28 0.58 1.44 3.56 5.45 10.99 Female 6–11 248 0.06 0.09 0.11 0.15 0.26 0.57 2.06 4.35 7.67 12–17 236 0.07 0.10 0.12 0.15 0.24 0.43 1.25 2.35 4.93 18–44 425 0.11 0.13 0.17 0.25 0.44 0.98 2.07 4.17 6.74 45–59 415 0.14 0.19 0.25 0.43 0.85 1.70 3.97 8.13 22.31 ≥ 60 398 0.16 0.23 0.32 0.59 1.08 2.26 4.48 7.28 10.39 Subtotal 1,800 0.10 0.12 0.15 0.26 0.59 1.41 3.22 5.68 9.00 Pregnant 78 0.18 0.29 0.41 0.74 1.50 2.59 4.22 6.66 7.86 Table 2. Percentile distribution of hsCRP for population in the large cities (mg/L)
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The average concentration of hsCRP in large urban residents was 0.67 mg/L, with 0.68 mg/L for men and 0.65 mg/L for women. The difference in hsCRP among the different age groups was statistically significant (P < 0.05), and the details are shown in Table 1. No significant difference in hsCRP levels was found between males and females aged ≥ 60 years and aged 45–59 years, but the two groups had significantly higher hsCRP levels than the other age subgroups (P < 0.05).
At the same time, the hsCRP levels in the 18–44 year-old group was significantly higher than that in the 6–11 and 12–17 year-old groups (P < 0.01). The highest hsCRP concentration was found in pregnant women in large cities. It was not significantly different from that in the ≥ 60-year-old group but significantly higher than those in the four other age groups ( P < 0.05). Meanwhile, the levels in the 45–59-year-old group were significantly higher than those in the 6–11, 12–17, and 18–44 year-old groups ( P < 0.01). The levels in the 18–44 year-old group were significantly higher than those in the 6–11 and 12–17 year-old groups ( P < 0.01). No significant difference in hsCRP was found between the 6–11 and 12–17 year-old groups.
The effect of different ages and genders on hsCRP in the residents of large cities is shown in Figure 1. The hsCRP increased with increasing age for the females and males. The concentration of hsCRP was substantially higher in the women aged > 55 years old than in the younger females. As shown in Figure 2, the distribution of hsCRP frequency in large cities was non-normally distributed.
The box plots of hsCRP distribution for residents of different ages and genders are shown in Figure 3. The highest median hsCRP was found in pregnant women.
Figure 3. Box plots presenting the distribution of hsCRP for population by age and sex in large cities.
The distribution of percentiles of hsCRP levels in residents of urban areas is shown in Table 2.
Distribution of High-sensitivity C-reactive Protein Status in an Urban Population in China
doi: 10.3967/bes2020.054
- Received Date: 2019-06-23
- Accepted Date: 2020-01-06
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Key words:
- High-sensitivity C-reactive protein /
- Urban population /
- Inflammation /
- Distribution
Abstract:
Citation: | TANG Yan Bin, HUO Jun Sheng, HUANG Jian, LI Hong, PIAO Jian Hua, SUN Jing, WANG Li Juan. Distribution of High-sensitivity C-reactive Protein Status in an Urban Population in China[J]. Biomedical and Environmental Sciences, 2020, 33(6): 396-402. doi: 10.3967/bes2020.054 |