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In total, 55 nodules in 20 hordeolum patients underwent treatment with IPL from July 2021 to February 2022 were enrolled in this study. Data were collected before and after treatment, and the completed form was filed in the medical record. The patients’ demographic and clinical data included age, sex, type of hordeola, number of recurrences in the past year and related factors before treatment (Table 1). Among the 13 women (65%) and 7 men (35%), there were 6 cases of single monocular hordeolum (30%), 2 cases of multiple monocular (10%) and 12 cases of multiple binocular hordeola (60%). All patients experienced more than one recurrence.
Case Age Sex Eye Type Quantity and position Duration of disease (days) Recurrent Times With blepharitis With acne vulgaris 1 44 F OD SGL 1 in upper eyelid 15 2 No No 2 35 M OD SGL 1 in lower eyelid 20 3 No No 3 51 M OS SGL 1 in upper eyelid 21 1 No No 4 33 F OS SGL 1 in lower eyelid 16 1 No No 5 32 F OS SGL 1 in lower eyelid 18 3 No No 6 57 M OS SGL 1 in upper eyelid 22 2 No No 7 28 F OD MULT 1 in lower eyelid
1 in upper eyelid28 3 No No 8 52 F OS MULT 2 in upper eyelid 15 1 No No 9 42 M BO MULT 1 in right upper eyelid
1 in left upper eyelid21 3 No No 10 24 F BO MULT 1 in right upper eyelid
1 in right lower eyelid
2 in left upper eyelid16 2 No No 11 38 F BO MULT 2 in right lower eyelid
1 in left upper eyelid18 1 Yes No 12 31 F BO MULT 2 in right upper eyelid
1 in left upper eyelid24 2 Yes Yes 13 55 F BO MULT 2 in right upper eyelid
1 in right lower eyelid
1 in left upper eyelid
2 in left lower eyelid21 5 Yes No 14 44 M BO MULT 2 in right lower eyelid
1 in left lower eyelid15 3 No Yes 15 48 F BO MULT 1 in right upper eyelid
2 in left lower eyelid20 1 Yes No 16 54 F BO MULT 2 in right upper eyelid
1 in left upper eyelid
1 in left lower eyelid28 3 Yes No 17 26 F BO MULT 2 in right upper eyelid
1 in right lower eyelid
2 in left upper eyelid
2 in left lower eyelid40 2 No No 18 45 M BO MULT 2 in right upper eyelid
2 in left upper eyelid25 1 No No 19 42 M BO MULT 2 in right upper eyelid
1 in left lower eyelid18 4 Yes No 20 52 F BO MULT 1 in right upper eyelid
2 in left upper eyelid14 3 No No Note. M, male; F, female; OD, right eye; OS, left eye; BO, binoculus; SGL, single; MULT, multiple. Table 1. Demographic data, clinical characteristics and recurrent times of patients before treatment
Changes in the VAS score were recorded and analysed. After IPL treatment, the VAS score of discomfort was reduced to 5.45 ± 8.79, which was significantly different from the score of 25.33 ± 7.97 before treatment (P < 0.05). Changes in nodules are presented in Table 2. There were 55 nodules before treatment, and the number decreased to 23 after IPL treatment. The size of nodules was also reduced. Changes in the MG and ocular surface signs are shown in Table 3. All of the signs except MGDR showd significant improvement.
Time Number of nodules CEA Score Relative long diameter of nodules Relative short diameter of nodules Relative area of nodules Before 55 3 (2, 3) 0.26 (0.17, 0.43) 0.26 (0.17, 0.26) 0.07 (0.03, 0.11) After 20# 1 (0, 1) 0.09 (0.00, 0.26) 0.09 (0.00, 0.17) 0.01 (0.00, 0.06) P* < 0.001 < 0.001 < 0.001 < 0.001 Note. #The relative diameter and area of missing nodules were marked the as 0 and included in the statistics. *P value of clustered wilcoxon rank sum test to compare data before and after treatment. CEA, clinician erythema assessment. Table 2. Changes of each nodule before and after treatment
Time Number of
sick eyesEyelid margin
signsMG
expressibilityMeibum
qualityMGDR
(upper eyelid)MGDR
(lower eyelid)TMH
(mm)CFS score Before 32 3 (3, 4) 1 (0, 2) 2 (2, 3) 3 (2, 3) 2 (2, 3) 0.16 (0.11, 0.20) 2 (1, 2) After 32 2 (1, 2) 1 (0, 1) 2 (1, 2) 3 (2, 3) 2 (2, 3) 0.21 (0.18, 0.24) 0 (0, 1) P* < 0.001 < 0.001 < 0.001 1.000 0.564 < 0.001 < 0.001 Note. *P value of clustered wilcoxon rank sum test to compare data before and after treatment. MG, meibomian gland; MGDR, meibomian gland dropout; TMH, tear meniscus height; CFS, corneal fluorescein staining. Table 3. Changes of meibomian gland and the signs of ocular surface before and after treatment
Images acquired under the slit lamp for single monocular, multiple monocular, and multiple binocular patients are shown in Figures 3, 4, and 5. Their subjective symptoms and objective signs improved significantly.
There were no significant changes in VA and IOP before and after treatment. The anterior segment and fundus in all patients also showed no significant changes. None of the patients complained of related side effects.
The Effect of Intense Pulsed Light Treatment for Chronic Hordeolum
doi: 10.3967/bes2023.131
- Received Date: 2023-05-22
- Accepted Date: 2023-08-22
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Key words:
- Intense pulsed light /
- Hordeolum /
- Chronic
Abstract:
Citation: | YANG Ke, WEN Ya, ZHU Lei, BAO Jia Yu, LI Shang, WANG Ying Hui, FENG Jun, TIAN Lei, JIE Ying. The Effect of Intense Pulsed Light Treatment for Chronic Hordeolum[J]. Biomedical and Environmental Sciences, 2023, 36(11): 1005-1014. doi: 10.3967/bes2023.131 |