Is KPNB3 Locus Associated With Schizophrenia

LI-BO LIU; YING HU; GUI-ZHI JU; XUAN ZHANG; LIN XIE; SHU-ZHENG LIU; JIE-PING SHI; YA-QIN YU; QI XU; YU FAN; YAN SHEN; JUN WEI

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Volume 20 Issue 1

Feb. 2007

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Article Navigation > Biomedical and Environmental Sciences > 2007 > 20(1): 52-55

LI-BO LIU, YING HU, GUI-ZHI JU, XUAN ZHANG, LIN XIE, SHU-ZHENG LIU, JIE-PING SHI, YA-QIN YU, QI XU, YU FAN, YAN SHEN, JUN WEI. Is KPNB3 Locus Associated With Schizophrenia[J]. Biomedical and Environmental Sciences, 2007, 20(1): 52-55.

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LI-BO LIU, YING HU, GUI-ZHI JU, XUAN ZHANG, LIN XIE, SHU-ZHENG LIU, JIE-PING SHI, YA-QIN YU, QI XU, YU FAN, YAN SHEN, JUN WEI. Is KPNB3 Locus Associated With Schizophrenia[J]. Biomedical and Environmental Sciences, 2007, 20(1): 52-55.

Is KPNB3 Locus Associated With Schizophrenia

Research Center for Genomic Medicine, School of Public Health, Jilin University, Changchun 130021, Jilin, China
Research Center for Genomic Medicine, School of Public Health, Jilin University, Changchun 130021, Jilin, China; School of Stomatology, Capital Medical University, Beijing 100050, China
The National Center for Genome Research (Beijing), Beijing 100176, China
Research Center for Genomic Medicine, School of Public Health, Jilin University, Changchun 130021, Jilin, China; Ness Foundation, UHI Millennium Institute, Inverness Ⅳ3 8GY, U. K.

Funds: 国家高技术研究发展计划(863计划)(2001AA221072and2004AA221070)%the National Key Technology Research and Development Program of China(2002BA711A07)%国家自然科学基金(39970165%30400263)%国家自然科学基金(5052021)

Abstract

Objective To reconfirm the association of KPNB3 with schizophrenia in Chinese population. Methods Two single nucleotide polymorphisms (SNPs), rs2588014 and rs626716 at the KPNB3 locus, were genotyped in 304 Chinese Han family trios consisting of fathers, mothers, and affected offsprings with schizophrenia. These 2 SNPs were detected by PCR-based restriction fragment length polymorphism (RFLP) analysis. The Hardy-Weinberg equilibrium for genotypic distributions was estimated by the goodness-of-fit test. The UNPHASED program was used to perform transmission disequilibrium test (TDT),haplotype analysis, and pair-wise measure of linkage disequilibrium (LD) between these 2 SNPs. Results The genotypic distributions of both rs2588014 and rs626716 were in the Hardy-Weinberg equilibrium (P＞0.05). The TDT revealed allelic association with rs626716 (χ2 =9.31, P=0.0023) but not with rs2588014 (χ2 =3.44, P=0.064). The global P-value was 0.0099 for 100 permutations. The haplotype analysis also showed a disease association (χ2 =25.97, df=3, P=0.0000097). Conclusion The present study provides further evidence in support of the KPNB3 association with schizophrenia in Chinese population.
- Chromosome 13,
- KPNB3,
- Single nucleotide polymorphisms (SNPs),
- Schizophrenia
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Is KPNB3 Locus Associated With Schizophrenia

Research Center for Genomic Medicine, School of Public Health, Jilin University, Changchun 130021, Jilin, China

Research Center for Genomic Medicine, School of Public Health, Jilin University, Changchun 130021, Jilin, China; School of Stomatology, Capital Medical University, Beijing 100050, China

The National Center for Genome Research (Beijing), Beijing 100176, China

Research Center for Genomic Medicine, School of Public Health, Jilin University, Changchun 130021, Jilin, China; Ness Foundation, UHI Millennium Institute, Inverness Ⅳ3 8GY, U. K.

Key words:

Chromosome 13 /
KPNB3 /
Single nucleotide polymorphisms (SNPs) /
Schizophrenia

Abstract: Objective To reconfirm the association of KPNB3 with schizophrenia in Chinese population. Methods Two single nucleotide polymorphisms (SNPs), rs2588014 and rs626716 at the KPNB3 locus, were genotyped in 304 Chinese Han family trios consisting of fathers, mothers, and affected offsprings with schizophrenia. These 2 SNPs were detected by PCR-based restriction fragment length polymorphism (RFLP) analysis. The Hardy-Weinberg equilibrium for genotypic distributions was estimated by the goodness-of-fit test. The UNPHASED program was used to perform transmission disequilibrium test (TDT),haplotype analysis, and pair-wise measure of linkage disequilibrium (LD) between these 2 SNPs. Results The genotypic distributions of both rs2588014 and rs626716 were in the Hardy-Weinberg equilibrium (P＞0.05). The TDT revealed allelic association with rs626716 (χ2 =9.31, P=0.0023) but not with rs2588014 (χ2 =3.44, P=0.064). The global P-value was 0.0099 for 100 permutations. The haplotype analysis also showed a disease association (χ2 =25.97, df=3, P=0.0000097). Conclusion The present study provides further evidence in support of the KPNB3 association with schizophrenia in Chinese population.

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