Induction of Chromosomal Aberrations by Propoxur in Mouse Bone Marrow Ceils
Abstract: Propoxur is a widely used dithiocarbamate insecticide. In this study, the clastogenic effect of propoxur has been evaluated using chromosomal aberration assay in mouse bone marrow cells. Singlei. p. administration of propoxur, at 25 nag/kg b.wt., a maximum tolerated dose (MTD) and 12.5mg/kg b.wt (50% of MTD) have significantly induced different types of aberrations after 24 h of treatment. The aberrations were dose and time dependent and reached a maximum after 24 h of exposure. The sresult suggest a genotoxic potential of propoxur.
|Citation:||R.C.AGRAWAL. Induction of Chromosomal Aberrations by Propoxur in Mouse Bone Marrow Ceils[J]. Biomedical and Environmental Sciences, 1999, 12(4): 292-295.|