Volume 22 Issue 1
Feb.  2009
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YAN-JUN LEI, CHEN GAO, CHEN WANG, JUN HAN, JIAN-MING CHEN, GUANG-CAI XIANG, QI SHI, HuI-YING JIANG, WEI ZHOU, RUN AN, CHEN-FANG DONG, YU-KANG YUAN, XIAO-PING DONG. Molecular Epidemiological Study on Prevalence of Human Papillomaviruses in Patients with Common Warts in Beijing Area[J]. Biomedical and Environmental Sciences, 2009, 22(1): 55-61.
Citation: YAN-JUN LEI, CHEN GAO, CHEN WANG, JUN HAN, JIAN-MING CHEN, GUANG-CAI XIANG, QI SHI, HuI-YING JIANG, WEI ZHOU, RUN AN, CHEN-FANG DONG, YU-KANG YUAN, XIAO-PING DONG. Molecular Epidemiological Study on Prevalence of Human Papillomaviruses in Patients with Common Warts in Beijing Area[J]. Biomedical and Environmental Sciences, 2009, 22(1): 55-61.

Molecular Epidemiological Study on Prevalence of Human Papillomaviruses in Patients with Common Warts in Beijing Area

  • Objective To study the circulation, distribution, and genomic diversity of HPVs in common warts in Beijing area of China. Methods Forty eight patients with pathologically diagnosed common warts were screened for the presence of HPV with HPV type-specific PCR and direct .sequencing analysis. The genomic diversity of HPVs prevalent in Chinese patients was analyzed based on LCR. Results Forty one (85.5%) samples were positive for HPV DNA, 13(31.7%)-HPV-57, 12(29.3%)-HPV-1 a, 7(17%)-HPV-27 and 5(12.2%)-HPV-2a. Four cases were infected with two different HPV types, two (4.9%) with HPV-1a and HPV-27, one (2.4%) with HPV-1 and HPV-57 and one (2.4%) with HPV-27 and HPV-57. In contrast to the prevalence of single strain of novel HPV-57 variant and HPV-1 prototype, two HPV-2 and three HPV-27 novel variants were found to circulate in Beijing. Conclusion HPV-1, -2, -27 and -57 are predominantly prevalent in patients with common warts in Beijing.
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通讯作者: 陈斌, bchen63@163.com
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Molecular Epidemiological Study on Prevalence of Human Papillomaviruses in Patients with Common Warts in Beijing Area

Abstract: Objective To study the circulation, distribution, and genomic diversity of HPVs in common warts in Beijing area of China. Methods Forty eight patients with pathologically diagnosed common warts were screened for the presence of HPV with HPV type-specific PCR and direct .sequencing analysis. The genomic diversity of HPVs prevalent in Chinese patients was analyzed based on LCR. Results Forty one (85.5%) samples were positive for HPV DNA, 13(31.7%)-HPV-57, 12(29.3%)-HPV-1 a, 7(17%)-HPV-27 and 5(12.2%)-HPV-2a. Four cases were infected with two different HPV types, two (4.9%) with HPV-1a and HPV-27, one (2.4%) with HPV-1 and HPV-57 and one (2.4%) with HPV-27 and HPV-57. In contrast to the prevalence of single strain of novel HPV-57 variant and HPV-1 prototype, two HPV-2 and three HPV-27 novel variants were found to circulate in Beijing. Conclusion HPV-1, -2, -27 and -57 are predominantly prevalent in patients with common warts in Beijing.

YAN-JUN LEI, CHEN GAO, CHEN WANG, JUN HAN, JIAN-MING CHEN, GUANG-CAI XIANG, QI SHI, HuI-YING JIANG, WEI ZHOU, RUN AN, CHEN-FANG DONG, YU-KANG YUAN, XIAO-PING DONG. Molecular Epidemiological Study on Prevalence of Human Papillomaviruses in Patients with Common Warts in Beijing Area[J]. Biomedical and Environmental Sciences, 2009, 22(1): 55-61.
Citation: YAN-JUN LEI, CHEN GAO, CHEN WANG, JUN HAN, JIAN-MING CHEN, GUANG-CAI XIANG, QI SHI, HuI-YING JIANG, WEI ZHOU, RUN AN, CHEN-FANG DONG, YU-KANG YUAN, XIAO-PING DONG. Molecular Epidemiological Study on Prevalence of Human Papillomaviruses in Patients with Common Warts in Beijing Area[J]. Biomedical and Environmental Sciences, 2009, 22(1): 55-61.

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