Numerical Simulation of Microcarrier Motion in a Rotating Wall Vessel Bioreactor

ZHI-HAO JU; TIAN-QING LIU; XUE-HU MA; ZHAN-FENG CUI

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Volume 19 Issue 3

Jun. 2006

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Article Navigation > Biomedical and Environmental Sciences > 2006 > 19(3): 163-168

ZHI-HAO JU, TIAN-QING LIU, XUE-HU MA, ZHAN-FENG CUI. Numerical Simulation of Microcarrier Motion in a Rotating Wall Vessel Bioreactor[J]. Biomedical and Environmental Sciences, 2006, 19(3): 163-168.

Citation:

ZHI-HAO JU, TIAN-QING LIU, XUE-HU MA, ZHAN-FENG CUI. Numerical Simulation of Microcarrier Motion in a Rotating Wall Vessel Bioreactor[J]. Biomedical and Environmental Sciences, 2006, 19(3): 163-168.

Numerical Simulation of Microcarrier Motion in a Rotating Wall Vessel Bioreactor

State Key Laboratory of Fine Chemical Engineering, Stem Cells & Tissue Engineering Laboratory, Dalian University of Technology, Dalian 116012, Liaoning, China
State Key Laboratory of Fine Chemical Engineering, Stem Cells & Tissue Engineering Laboratory, Dalian University of Technology, Dalian 116012, Liaoning, China;Department of Engineering Science, Oxford University, Oxford OX1 3P J, UK

Funds: Bureau of International Cooperation(2002008)%辽宁省科技计划(20022140)

Abstract

Objective To analyze the forces of rotational wall vessel (RWV) bioreactor on small tissue pieces or microcarrier particles and to determine the tracks of microcarrier particles in RWV bioreactor. Methods The motion of the microcarrier in the rotating wall vessel (RWV) bioreactor with both the inner and outer cylinders rotating was modeled by numerical simulation. Results The continuous trajectory of microcarrier particles, including the possible collision with the wall was obtained. An expression between the minimum rotational speed difference of the inner and outer cylinders and the microcarrier particle or aggregate radius could avoid collisions with either wall. The range of microcarrier radius or tissue size, which could be safely cultured in the RWV bioreactor, in terms of shear stress level, was determined. Conclusion The model works well in describing the trajectory of a heavier microcarrier particle in rotating wall vessel.
- Tissue engineering,
- Bioreactor,
- Rotating wall vessel,
- Numerical simulation
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Numerical Simulation of Microcarrier Motion in a Rotating Wall Vessel Bioreactor

State Key Laboratory of Fine Chemical Engineering, Stem Cells & Tissue Engineering Laboratory, Dalian University of Technology, Dalian 116012, Liaoning, China

State Key Laboratory of Fine Chemical Engineering, Stem Cells & Tissue Engineering Laboratory, Dalian University of Technology, Dalian 116012, Liaoning, China;Department of Engineering Science, Oxford University, Oxford OX1 3P J, UK

Funds: Bureau of International Cooperation(2002008)%辽宁省科技计划(20022140)

Key words:

Abstract: Objective To analyze the forces of rotational wall vessel (RWV) bioreactor on small tissue pieces or microcarrier particles and to determine the tracks of microcarrier particles in RWV bioreactor. Methods The motion of the microcarrier in the rotating wall vessel (RWV) bioreactor with both the inner and outer cylinders rotating was modeled by numerical simulation. Results The continuous trajectory of microcarrier particles, including the possible collision with the wall was obtained. An expression between the minimum rotational speed difference of the inner and outer cylinders and the microcarrier particle or aggregate radius could avoid collisions with either wall. The range of microcarrier radius or tissue size, which could be safely cultured in the RWV bioreactor, in terms of shear stress level, was determined. Conclusion The model works well in describing the trajectory of a heavier microcarrier particle in rotating wall vessel.

ZHI-HAO JU, TIAN-QING LIU, XUE-HU MA, ZHAN-FENG CUI. Numerical Simulation of Microcarrier Motion in a Rotating Wall Vessel Bioreactor[J]. Biomedical and Environmental Sciences, 2006, 19(3): 163-168.

Citation: