Job Stress, Gene Polymorphism of β2-AR, and Prevalence of Hypertension

Key words: 
• Job stress /
• Hypertension /
• β2-AR /
• Gene polymorphism

Abstract: Objective To study the interactive effect of job stress and genetic susceptibility (or gene polymorphism) on hypertension. Methods A cross-sectional epidemioiogical study was conducted in 452 workers from a thermal power plant in China. Extrinsic effort, occupational reward, and over-commitment were measured. Hypertensive patients were defined by three phases of screening, reexamination, and final diagnosis. β2-AR genotypes and allele frequencies at amino acid positions 16 (β2-AR-16:Arg→Gly) and 27(β2-AR-27:Gln→Glu) were identified by PCR-RFLP. Results Job stress was related with the prevalence of hypertension in males (P<0.05), whereas no significant relationship was found in females (P>0.05). Differences in genotypes and allele frequencies of the β2-AR-16 were statistically significant between the hypertension and control groups (P<0.05), whereas those of β2-AR-27 were not (P>0.05). The prevalence of hypertension was higher in individuals carrying Gly16 allele than in those carrying Arg16 allele of the high job stress group (P<0.01 or 0.05). Conclusion High job stress and polymorphism of β2-AR-16 have an interactive effect on the prevalence of hypertension in male workers.