Volume 22 Issue 6
Dec.  2009
Turn off MathJax
Article Contents

LI-JUN PEI, GONG CHEN, XIN-MING SONG, JI-LEI WU, CHENG-FU LI, JI-ZHEN ZOU, JIU-ZHI LIN, TING ZHANG, XIAO-YING ZHENG. Effect of Pathoanatomic Diagnosis on the Quality of Birth Defects Surveillance in China1[J]. Biomedical and Environmental Sciences, 2009, 22(6): 464-471.
Citation: LI-JUN PEI, GONG CHEN, XIN-MING SONG, JI-LEI WU, CHENG-FU LI, JI-ZHEN ZOU, JIU-ZHI LIN, TING ZHANG, XIAO-YING ZHENG. Effect of Pathoanatomic Diagnosis on the Quality of Birth Defects Surveillance in China1[J]. Biomedical and Environmental Sciences, 2009, 22(6): 464-471.

Effect of Pathoanatomic Diagnosis on the Quality of Birth Defects Surveillance in China1

Funds:  National 973 project on Population and Health(2007CB511901)%China Postdoctoral Science Fundation Funded Project(200801016)%National Health Baby Promotion Program(FP2000NO13)%Education Ministry Key Program(02185)%National Yang Zi Scholar Program%211 and 985 projects of Peking University(20020903)
  • Objective To provide evidence for more accurate diagnosis of birth defects based on the pathoanatomy of congenital malformations. Methods Data used in this study were obtained from Luliang City Hospital and three county hospitals of Shanxi province between February 2004 and March 2006. Autopsy and pathological examination of 160 dead fetuses and stillbirths were performed. Photos of dead fetuses and stillbirths were taken, tissues were cut into sections for pathological examination under microscope, all pathological information was recorded, and percentage of birth defects was calculated.Results The proportion of dead fetuses and stillbirths with or without congenital malformations was 84.4% (135/160) and 15.6% (25/160), respectively. There were 16 categories of major external and internal birth defects in 135 cases of such defects.Congenital heart defects, anencephaly and spina bifida had a higher prevalence rate in the study period. The prevalence rate of non-malformation death and birth defects < 28 gestational weeks and internal anomalies≥ 28 gestational weeks was 14.61% (61/4175) and 17.25% (72/4175), respectively. A total of 413 in situ anomalies were found in 135 cases of autopsy. Spina bifida,anencephaly, congenital heart defects, aplasia or accessory lobe of lung, renal agenesis and dysplasis and congenital hydrocephaly were more closely associated with severe malformations than with mitis malformations. The cases of dead fetuses and stillbirths with multiple malformations (≥ 2 in situ anomalies) had a higher proportion (74.1%), whereas those with isolated malformations had a lower proportion (25.93%). Conclusion The occurrence of congenital malformations in different embryonic developmental stages affects multiple organs. Postmortem examination of internal and multiple malformations of fetal deaths and stillbirths can provide more accurate diagnostic information for birth defects.
  • 加载中
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(1051) PDF downloads(25) Cited by()

Proportional views
Related

Effect of Pathoanatomic Diagnosis on the Quality of Birth Defects Surveillance in China1

Funds:  National 973 project on Population and Health(2007CB511901)%China Postdoctoral Science Fundation Funded Project(200801016)%National Health Baby Promotion Program(FP2000NO13)%Education Ministry Key Program(02185)%National Yang Zi Scholar Program%211 and 985 projects of Peking University(20020903)

Abstract: Objective To provide evidence for more accurate diagnosis of birth defects based on the pathoanatomy of congenital malformations. Methods Data used in this study were obtained from Luliang City Hospital and three county hospitals of Shanxi province between February 2004 and March 2006. Autopsy and pathological examination of 160 dead fetuses and stillbirths were performed. Photos of dead fetuses and stillbirths were taken, tissues were cut into sections for pathological examination under microscope, all pathological information was recorded, and percentage of birth defects was calculated.Results The proportion of dead fetuses and stillbirths with or without congenital malformations was 84.4% (135/160) and 15.6% (25/160), respectively. There were 16 categories of major external and internal birth defects in 135 cases of such defects.Congenital heart defects, anencephaly and spina bifida had a higher prevalence rate in the study period. The prevalence rate of non-malformation death and birth defects < 28 gestational weeks and internal anomalies≥ 28 gestational weeks was 14.61% (61/4175) and 17.25% (72/4175), respectively. A total of 413 in situ anomalies were found in 135 cases of autopsy. Spina bifida,anencephaly, congenital heart defects, aplasia or accessory lobe of lung, renal agenesis and dysplasis and congenital hydrocephaly were more closely associated with severe malformations than with mitis malformations. The cases of dead fetuses and stillbirths with multiple malformations (≥ 2 in situ anomalies) had a higher proportion (74.1%), whereas those with isolated malformations had a lower proportion (25.93%). Conclusion The occurrence of congenital malformations in different embryonic developmental stages affects multiple organs. Postmortem examination of internal and multiple malformations of fetal deaths and stillbirths can provide more accurate diagnostic information for birth defects.

LI-JUN PEI, GONG CHEN, XIN-MING SONG, JI-LEI WU, CHENG-FU LI, JI-ZHEN ZOU, JIU-ZHI LIN, TING ZHANG, XIAO-YING ZHENG. Effect of Pathoanatomic Diagnosis on the Quality of Birth Defects Surveillance in China1[J]. Biomedical and Environmental Sciences, 2009, 22(6): 464-471.
Citation: LI-JUN PEI, GONG CHEN, XIN-MING SONG, JI-LEI WU, CHENG-FU LI, JI-ZHEN ZOU, JIU-ZHI LIN, TING ZHANG, XIAO-YING ZHENG. Effect of Pathoanatomic Diagnosis on the Quality of Birth Defects Surveillance in China1[J]. Biomedical and Environmental Sciences, 2009, 22(6): 464-471.

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return