Interaction and Relationship Between Angiotensin Converting Enzyme Gene and Environmental Factors Predisposing to Essential Hypertension in Mongolian Population of China

QUN XU; YAN-HUA WANG; WEI-JUN TONG; MING-LIANG GU; GANG WU; BATU BUREN; YONG-YUE LIU; JIAN WANG; YONG-SHAN LI; HUA Feng; SHUANG-LIAN BAI; HAI-HUA PANG; GUI-RONG HUANG; MING-WU FANG; Yong-hong ZHANG; ZHENG-LAI WU; Chang-chun Qiu

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Volume 17 Issue 2

Jun. 2004

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Article Navigation > Biomedical and Environmental Sciences > 2004 > 17(2): 177-186

QUN XU, YAN-HUA WANG, WEI-JUN TONG, MING-LIANG GU, GANG WU, BATU BUREN, YONG-YUE LIU, JIAN WANG, YONG-SHAN LI, HUA Feng, SHUANG-LIAN BAI, HAI-HUA PANG, GUI-RONG HUANG, MING-WU FANG, Yong-hong ZHANG, ZHENG-LAI WU, Chang-chun Qiu. Interaction and Relationship Between Angiotensin Converting Enzyme Gene and Environmental Factors Predisposing to Essential Hypertension in Mongolian Population of China[J]. Biomedical and Environmental Sciences, 2004, 17(2): 177-186.

Citation:

QUN XU, YAN-HUA WANG, WEI-JUN TONG, MING-LIANG GU, GANG WU, BATU BUREN, YONG-YUE LIU, JIAN WANG, YONG-SHAN LI, HUA Feng, SHUANG-LIAN BAI, HAI-HUA PANG, GUI-RONG HUANG, MING-WU FANG, Yong-hong ZHANG, ZHENG-LAI WU, Chang-chun Qiu. Interaction and Relationship Between Angiotensin Converting Enzyme Gene and Environmental Factors Predisposing to Essential Hypertension in Mongolian Population of China[J]. Biomedical and Environmental Sciences, 2004, 17(2): 177-186.

Interaction and Relationship Between Angiotensin Converting Enzyme Gene and Environmental Factors Predisposing to Essential Hypertension in Mongolian Population of China

National Laboratory of Medical Molecular Biology, School of Basic Medicine, Peking College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China;Department of Epidemiology, School of Basic Medicine, Peking Union
Department of Epidemiology, Public Health School, Harbin Medical University, Harbin 150001, Heilongjiang, China
Center for Disease Control and Prevention of Tongliao, Tongliao 028000, Inner Mongaln, China
National Laboratory of Medical Molecular Biology, School of Basic Medicine, Peking College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China
Center Hospital of Tongliao, TongLiao 028000,Inner Mongolia China
Center for Disease Control and Prevention of Kezuohouqi, Kezuohouqi 028100, China
Department of Epidemiology, School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China

Funds: 北京市自然科学基金(Grant 7001004)%Research Fund for the Doctoral Training Program from the Ministry of Education(Grant 20020023009)%Foundation of China Medical Board of New York, Inc(Grant 96-657)

Abstract

Objective To investigate the association of specific functional gene ACE (I/D) variants of the renin-angiotensin system with essential hypertension (EH) and interaction between ACE (I/D) gene and risk factors for EH in a genetically homogenous Mongolia rural population of China. Methods Individuals (n=1099) were recruited from general population of Kezuohouqi Banner in Inner Mongolian Autonomous Region. Results The association was found between ACE genotype DD plus ID and EH, with an interaction between ACE genotype DD plus ID and cigarette smoking in an additive model. Cigarette smoking index and ACE gene showed a low exposure-gene (LEG) effect on EH, with interaction indices from 7.10 to 1.16. Interaction between ACE genotype DD plus ID and alcohol drinking on EH appeared an additive model. Alcohol drinking index and ACE gene showed a low exposure-gene (LEG) effect on EH, with interaction indices from 1.66 to 1.09. BMI and ACE gene showed a low exposure-gene (LEG) effect on EH, with interaction indices from 6.15 to 2.49. Interactions between ACE genotype and WHR on EH showed a multiplicative model. In a short, there was an interaction between ACE gene and cigarette smoking, alcohol drinking and BMI on EH, especially in a low dose-exposure effect. Conclusion It is important for individuals who carry ACE D allele gene to prevent EH, and furthermore, to prevent and control coronary heart disease, in a view of population-based prevention.
- Angiotensin-converting enzyme,
- Hypertension,
- Genetic,
- Risk factors,
- Interaction,
- Exposure-gene effect
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Interaction and Relationship Between Angiotensin Converting Enzyme Gene and Environmental Factors Predisposing to Essential Hypertension in Mongolian Population of China

National Laboratory of Medical Molecular Biology, School of Basic Medicine, Peking College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China;Department of Epidemiology, School of Basic Medicine, Peking Union

Department of Epidemiology, Public Health School, Harbin Medical University, Harbin 150001, Heilongjiang, China

Center for Disease Control and Prevention of Tongliao, Tongliao 028000, Inner Mongaln, China

National Laboratory of Medical Molecular Biology, School of Basic Medicine, Peking College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China

Center Hospital of Tongliao, TongLiao 028000,Inner Mongolia China

Center for Disease Control and Prevention of Kezuohouqi, Kezuohouqi 028100, China

Department of Epidemiology, School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China

Key words:

Abstract: Objective To investigate the association of specific functional gene ACE (I/D) variants of the renin-angiotensin system with essential hypertension (EH) and interaction between ACE (I/D) gene and risk factors for EH in a genetically homogenous Mongolia rural population of China. Methods Individuals (n=1099) were recruited from general population of Kezuohouqi Banner in Inner Mongolian Autonomous Region. Results The association was found between ACE genotype DD plus ID and EH, with an interaction between ACE genotype DD plus ID and cigarette smoking in an additive model. Cigarette smoking index and ACE gene showed a low exposure-gene (LEG) effect on EH, with interaction indices from 7.10 to 1.16. Interaction between ACE genotype DD plus ID and alcohol drinking on EH appeared an additive model. Alcohol drinking index and ACE gene showed a low exposure-gene (LEG) effect on EH, with interaction indices from 1.66 to 1.09. BMI and ACE gene showed a low exposure-gene (LEG) effect on EH, with interaction indices from 6.15 to 2.49. Interactions between ACE genotype and WHR on EH showed a multiplicative model. In a short, there was an interaction between ACE gene and cigarette smoking, alcohol drinking and BMI on EH, especially in a low dose-exposure effect. Conclusion It is important for individuals who carry ACE D allele gene to prevent EH, and furthermore, to prevent and control coronary heart disease, in a view of population-based prevention.

Citation:

QUN XU, YAN-HUA WANG, WEI-JUN TONG, MING-LIANG GU, GANG WU, BATU BUREN, YONG-YUE LIU, JIAN WANG, YONG-SHAN LI, HUA Feng, SHUANG-LIAN BAI, HAI-HUA PANG, GUI-RONG HUANG, MING-WU FANG, Yong-hong ZHANG, ZHENG-LAI WU, Chang-chun Qiu. Interaction and Relationship Between Angiotensin Converting Enzyme Gene and Environmental Factors Predisposing to Essential Hypertension in Mongolian Population of China[J]. Biomedical and Environmental Sciences, 2004, 17(2): 177-186.