Volume 22 Issue 6
Dec.  2009
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SU-ZHEN JIANG, ZHI-YONG GAO, TONG LI, YA-JUAN LI, XIANG-MEI CHEN, LING WANG, FENG-MIN LU, HUI ZHUANG. T3098C and T53C Mutations of HBV Genotype C Is Associated with HBV Infection Progress1[J]. Biomedical and Environmental Sciences, 2009, 22(6): 511-517.
Citation: SU-ZHEN JIANG, ZHI-YONG GAO, TONG LI, YA-JUAN LI, XIANG-MEI CHEN, LING WANG, FENG-MIN LU, HUI ZHUANG. T3098C and T53C Mutations of HBV Genotype C Is Associated with HBV Infection Progress1[J]. Biomedical and Environmental Sciences, 2009, 22(6): 511-517.

T3098C and T53C Mutations of HBV Genotype C Is Associated with HBV Infection Progress1

Funds:  the financial grants from Beijing Municipal Science & Technology Commission(D08050702870000)%Basic Research Project (973Project)(2005CB523104)%the National Projects on the Control of Major Infectious Diseases(2008ZX10002-012%2008ZX10002-004)
  • Objective To analyze the association between mutation(s) in preS region of HBV and hepatitis B disease progress in Chinese patients with genotype C chronic HBV infection. Methods Ninety-three patients with chronic genotype C HBV infection, including 24 asymptomatic carriers (ASC), 26 patients with chronic hepatitis B (CHB), 22 patients with liver cirrhosis (LC) and 21 HCC patients were investigated. Levels of HBV DNA, HBeAg, alanine aminotransferase (ALT), asparate transaminase (AST) were measured. HBV preS region was analyzed by PCR direct sequencing. Results The prevalence of lareS T3098C and T53C mutations of genotype C HBV was significantly higher in LC and HCC patients than ASC and CHB patients. The rate of T3098C mutation in ASC, CHB, LC, and HCC patients were 0.00% (0/24), 3.85% (1/26), 9.09% (2/22),and 30.77% (8/22), respectively (P=-0.0015), while the rate of T53C mutation was 12.50% (3/24), 3.85% (1/26), 40.91% (9/22),and 42.31% (11/26), respectively (P=0.0012). Conclusion The frequency of genotype C HBV preS T3098C and T53Cmutations is associated with hepatitis B infection progression.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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T3098C and T53C Mutations of HBV Genotype C Is Associated with HBV Infection Progress1

Funds:  the financial grants from Beijing Municipal Science & Technology Commission(D08050702870000)%Basic Research Project (973Project)(2005CB523104)%the National Projects on the Control of Major Infectious Diseases(2008ZX10002-012%2008ZX10002-004)

Abstract: Objective To analyze the association between mutation(s) in preS region of HBV and hepatitis B disease progress in Chinese patients with genotype C chronic HBV infection. Methods Ninety-three patients with chronic genotype C HBV infection, including 24 asymptomatic carriers (ASC), 26 patients with chronic hepatitis B (CHB), 22 patients with liver cirrhosis (LC) and 21 HCC patients were investigated. Levels of HBV DNA, HBeAg, alanine aminotransferase (ALT), asparate transaminase (AST) were measured. HBV preS region was analyzed by PCR direct sequencing. Results The prevalence of lareS T3098C and T53C mutations of genotype C HBV was significantly higher in LC and HCC patients than ASC and CHB patients. The rate of T3098C mutation in ASC, CHB, LC, and HCC patients were 0.00% (0/24), 3.85% (1/26), 9.09% (2/22),and 30.77% (8/22), respectively (P=-0.0015), while the rate of T53C mutation was 12.50% (3/24), 3.85% (1/26), 40.91% (9/22),and 42.31% (11/26), respectively (P=0.0012). Conclusion The frequency of genotype C HBV preS T3098C and T53Cmutations is associated with hepatitis B infection progression.

SU-ZHEN JIANG, ZHI-YONG GAO, TONG LI, YA-JUAN LI, XIANG-MEI CHEN, LING WANG, FENG-MIN LU, HUI ZHUANG. T3098C and T53C Mutations of HBV Genotype C Is Associated with HBV Infection Progress1[J]. Biomedical and Environmental Sciences, 2009, 22(6): 511-517.
Citation: SU-ZHEN JIANG, ZHI-YONG GAO, TONG LI, YA-JUAN LI, XIANG-MEI CHEN, LING WANG, FENG-MIN LU, HUI ZHUANG. T3098C and T53C Mutations of HBV Genotype C Is Associated with HBV Infection Progress1[J]. Biomedical and Environmental Sciences, 2009, 22(6): 511-517.

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