Effects of Electromagnetic Pulse on Bone Metabolism of Mice in vivo

KANG-CHU LI; SHI-RONG MA; GUI-RONG DING; YAO GUO; GUO-ZHEN GUO

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Volume 22 Issue 6

Dec. 2009

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Article Navigation > Biomedical and Environmental Sciences > 2009 > 22(6): 518-521

KANG-CHU LI, SHI-RONG MA, GUI-RONG DING, YAO GUO, GUO-ZHEN GUO. Effects of Electromagnetic Pulse on Bone Metabolism of Mice in vivo[J]. Biomedical and Environmental Sciences, 2009, 22(6): 518-521.

Citation:

KANG-CHU LI, SHI-RONG MA, GUI-RONG DING, YAO GUO, GUO-ZHEN GUO. Effects of Electromagnetic Pulse on Bone Metabolism of Mice in vivo[J]. Biomedical and Environmental Sciences, 2009, 22(6): 518-521.

Effects of Electromagnetic Pulse on Bone Metabolism of Mice in vivo

Department of Radiation Medicine, Fourth Military Medical University, Xi 'an 710032, Shaanxi China
Department of Pathology, Fourth Military Medical University, Xi 'an 710032, Shaanxi China

Funds: the Research Fund of National Natural Science Foundation of China(30800928%30670492)%the National 863 Project(2006 AA02Z4C3)

Abstract

Objective To study the effects of electromagnetic pulse (EMP) on bone metabolism of mice in vivo. Methods Twenty-four male BALB/c mice were divided into a control group and 2 experimental groups (n=8). The whole-body of mice in experimental groups were exposed to 50 kV/m and 400kV/m EMP, 400 pulses daily for 7 consecutive days at 2 seconds intervals. Alkaline phosphotase (ALP) activity, serum calcium concentration and osteocalcin level and trabecular bone volume (BV/TV, %) were measured immediately after EMP exposure by biochemical, ELISA and morphological methods. Results The ALP activity, serum calcium concentration and osteocalcin level and BV/TV in experimental groups remained unchanged after EMP exposure. Conclusion Under our experimental conditions, EMP exposure cannot affect bone metabolism of mice in vivo.
- Electromagnetic pulse,
- Alkaline phosphotase,
- Serum calcium,
- Osteocalcin,
- Trabecular bone volume
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Effects of Electromagnetic Pulse on Bone Metabolism of Mice in vivo

Department of Radiation Medicine, Fourth Military Medical University, Xi 'an 710032, Shaanxi China

Department of Pathology, Fourth Military Medical University, Xi 'an 710032, Shaanxi China

Funds: the Research Fund of National Natural Science Foundation of China(30800928%30670492)%the National 863 Project(2006 AA02Z4C3)

Key words:

Abstract: Objective To study the effects of electromagnetic pulse (EMP) on bone metabolism of mice in vivo. Methods Twenty-four male BALB/c mice were divided into a control group and 2 experimental groups (n=8). The whole-body of mice in experimental groups were exposed to 50 kV/m and 400kV/m EMP, 400 pulses daily for 7 consecutive days at 2 seconds intervals. Alkaline phosphotase (ALP) activity, serum calcium concentration and osteocalcin level and trabecular bone volume (BV/TV, %) were measured immediately after EMP exposure by biochemical, ELISA and morphological methods. Results The ALP activity, serum calcium concentration and osteocalcin level and BV/TV in experimental groups remained unchanged after EMP exposure. Conclusion Under our experimental conditions, EMP exposure cannot affect bone metabolism of mice in vivo.

KANG-CHU LI, SHI-RONG MA, GUI-RONG DING, YAO GUO, GUO-ZHEN GUO. Effects of Electromagnetic Pulse on Bone Metabolism of Mice in vivo[J]. Biomedical and Environmental Sciences, 2009, 22(6): 518-521.

Citation:

KANG-CHU LI, SHI-RONG MA, GUI-RONG DING, YAO GUO, GUO-ZHEN GUO. Effects of Electromagnetic Pulse on Bone Metabolism of Mice in vivo[J]. Biomedical and Environmental Sciences, 2009, 22(6): 518-521.