Volume 20 Issue 4
Aug.  2007
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LI-JIAN LEI, TAI-YI JIN, YUAN-FEN ZHOU. Insulin Expression in Rats Exposed to Cadmium[J]. Biomedical and Environmental Sciences, 2007, 20(4): 295-301.
Citation: LI-JIAN LEI, TAI-YI JIN, YUAN-FEN ZHOU. Insulin Expression in Rats Exposed to Cadmium[J]. Biomedical and Environmental Sciences, 2007, 20(4): 295-301.

Insulin Expression in Rats Exposed to Cadmium

Funds:  国家重点基础研究发展计划(973计划)(2002 CB 512905)
  • Objectives To investigate the effects of cadmium exposure on insulin expression in rats. Methods Eighteen adult SD assessed. The levels of cadmium and zinc in pancreas, blood and urine glucose, serum insulin and urine NAG (N-acyetyl-β-glucosaminidase) were determined. The gene expressions of metallothionein (MT) and insulin were also measured,and the oral glucose tolerance tests (OGTT) were carried out. Results The contents of cadmium in pancreas in cadmium-treated rats were higher than that in the control group, which was associated with slight increase of zinc in pancreas.not change significantly after cadmium administration, and the UNAG had no change in Cd-treated group. The gene expression the change of the expression of insulin, MT-Ⅰ and MT-Ⅱ genes. Cadmium can influence the biosynthesis of insulin, but does not induce the release of insulin. The dysfunction of pancreas occurs earlier than that of kidney after administration of cadmium.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Insulin Expression in Rats Exposed to Cadmium

Funds:  国家重点基础研究发展计划(973计划)(2002 CB 512905)

Abstract: Objectives To investigate the effects of cadmium exposure on insulin expression in rats. Methods Eighteen adult SD assessed. The levels of cadmium and zinc in pancreas, blood and urine glucose, serum insulin and urine NAG (N-acyetyl-β-glucosaminidase) were determined. The gene expressions of metallothionein (MT) and insulin were also measured,and the oral glucose tolerance tests (OGTT) were carried out. Results The contents of cadmium in pancreas in cadmium-treated rats were higher than that in the control group, which was associated with slight increase of zinc in pancreas.not change significantly after cadmium administration, and the UNAG had no change in Cd-treated group. The gene expression the change of the expression of insulin, MT-Ⅰ and MT-Ⅱ genes. Cadmium can influence the biosynthesis of insulin, but does not induce the release of insulin. The dysfunction of pancreas occurs earlier than that of kidney after administration of cadmium.

LI-JIAN LEI, TAI-YI JIN, YUAN-FEN ZHOU. Insulin Expression in Rats Exposed to Cadmium[J]. Biomedical and Environmental Sciences, 2007, 20(4): 295-301.
Citation: LI-JIAN LEI, TAI-YI JIN, YUAN-FEN ZHOU. Insulin Expression in Rats Exposed to Cadmium[J]. Biomedical and Environmental Sciences, 2007, 20(4): 295-301.

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