Unusual Patterns of Neural Tube Defects in a High Risk Region of Northern China

GONG CHEN; LI-JUN PEI; JIAN HUANG; XIN-MING SONG; LIANG-MING LIN; XUE GU; JIAN-XINWU; FANG WANG; JI-LEI WU; JIA-PENG CHEN; JU-FEN LIU; RUO-LEI XIN; TING ZHANG; XIAO-YING ZHENG

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Volume 22 Issue 4

Aug. 2009

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Article Navigation > Biomedical and Environmental Sciences > 2009 > 22(4): 340-344

GONG CHEN, LI-JUN PEI, JIAN HUANG, XIN-MING SONG, LIANG-MING LIN, XUE GU, JIAN-XINWU, FANG WANG, JI-LEI WU, JIA-PENG CHEN, JU-FEN LIU, RUO-LEI XIN, TING ZHANG, XIAO-YING ZHENG. Unusual Patterns of Neural Tube Defects in a High Risk Region of Northern China[J]. Biomedical and Environmental Sciences, 2009, 22(4): 340-344.

Citation:

GONG CHEN, LI-JUN PEI, JIAN HUANG, XIN-MING SONG, LIANG-MING LIN, XUE GU, JIAN-XINWU, FANG WANG, JI-LEI WU, JIA-PENG CHEN, JU-FEN LIU, RUO-LEI XIN, TING ZHANG, XIAO-YING ZHENG. Unusual Patterns of Neural Tube Defects in a High Risk Region of Northern China[J]. Biomedical and Environmental Sciences, 2009, 22(4): 340-344.

Unusual Patterns of Neural Tube Defects in a High Risk Region of Northern China

Institute of Population Research, Peking University, Beijing 100871, China
Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China
Capital Institute of Pediatrics, Beijing 100020, China

Funds: 国家重点基础研究发展规划(973计划)(007CB511901)%National Postdoctoral fund(200801016)%National Health Baby Promotion Program(FP2000NO13)%Education Ministry Key Program(02185)%National Yangzi Scholar Program, 211 and 985 Projects of Peking University(20020903)

Abstract

Objectives To study the prevalence of different types of neural tube defects (NTDs) in Luliang Prefecture, Shanxi province, where the prevalence of NTDs is unusually high and the correlation between NTDs prevalence and patterns. Methods A surveillance population-based birth defects was performed in Luliang Prefecture, Shanxi province. Results The results of our study showed that the prevalence of NTDs was 2-fold higher in Luliang Prefecture than in other areas of Shanxi province. Unusual patterns of NTDs were found, however, multiple NTDs were relatively common in Luliang Prefecture, accounting for over 13% of all NTDs cases in China. Conclusion The prevalence of NTDs is associated with its patterns.
- Neural tube defects,
- Epidemioiogy,
- Geographic variation
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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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Unusual Patterns of Neural Tube Defects in a High Risk Region of Northern China

Institute of Population Research, Peking University, Beijing 100871, China

Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China

Capital Institute of Pediatrics, Beijing 100020, China

Key words:

Abstract: Objectives To study the prevalence of different types of neural tube defects (NTDs) in Luliang Prefecture, Shanxi province, where the prevalence of NTDs is unusually high and the correlation between NTDs prevalence and patterns. Methods A surveillance population-based birth defects was performed in Luliang Prefecture, Shanxi province. Results The results of our study showed that the prevalence of NTDs was 2-fold higher in Luliang Prefecture than in other areas of Shanxi province. Unusual patterns of NTDs were found, however, multiple NTDs were relatively common in Luliang Prefecture, accounting for over 13% of all NTDs cases in China. Conclusion The prevalence of NTDs is associated with its patterns.

Citation:

GONG CHEN, LI-JUN PEI, JIAN HUANG, XIN-MING SONG, LIANG-MING LIN, XUE GU, JIAN-XINWU, FANG WANG, JI-LEI WU, JIA-PENG CHEN, JU-FEN LIU, RUO-LEI XIN, TING ZHANG, XIAO-YING ZHENG. Unusual Patterns of Neural Tube Defects in a High Risk Region of Northern China[J]. Biomedical and Environmental Sciences, 2009, 22(4): 340-344.