Volume 15 Issue 2
Jun.  2002
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TANG XIAO-JIANG, LI LAI-YU, HUANG Jian-xun, DENG YING-YU. Guinea Pig Maximization Test for Trichloroethylene and Its Metabolites[J]. Biomedical and Environmental Sciences, 2002, 15(2): 113-118.
Citation: TANG XIAO-JIANG, LI LAI-YU, HUANG Jian-xun, DENG YING-YU. Guinea Pig Maximization Test for Trichloroethylene and Its Metabolites[J]. Biomedical and Environmental Sciences, 2002, 15(2): 113-118.

Guinea Pig Maximization Test for Trichloroethylene and Its Metabolites

Funds:  supported by Guangdong Provincial Committee of Science and Technology, China(GCST 9622056-05)
  • Objectives To study the contact allergenic activities of trichloroethylene (TCE) and its three metabolites trichloroacetic acid, trichloroethanol and chloral hydrate. Methods A modified guinea pig maximization test (GPMT) was adopted. The skin sensitization (edema and erythema) was observed in trichloroethylene, trichloroacetic acid, trichloroethanol, chloral hydrate and 2,4-dinitrochlorobenzene. Results The allergenic rate of TCE, trichloroacetic acid and 2,4-dinitrochlorobenzene was 71.4%, 58.3% and 100.0% respectively, and that of trichloroethanol and chloral hydrate was 0%. The mean response score of TCE, trichloroacetic acid and 2,4-dinitrochlorobenzene was 2.3, 1.1, 6.0 respectively. The histopathological analysis also showed an induction of allergenic transfomation in guinea pig skin by both TCE and trichloroacetic acid. Conclusion TCE appears to be a strong allergen while trichloroacetic acid a moderate one. On the other hand, both trichloroethanol and chloral hydrate are weak sensitization potentials. Immunologic reaction induced by TCE might be postulated as the pathological process of this illness. Consequently, it is suggested that in the mechanism of Occupational Dermatitis Medicamentose-Like (ODML) induced by TCE, the chemical itself might be the main cause of allergy. As one of its metabolic products, trichloroacetic acid might be a subordinate factor.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Guinea Pig Maximization Test for Trichloroethylene and Its Metabolites

Funds:  supported by Guangdong Provincial Committee of Science and Technology, China(GCST 9622056-05)

Abstract: Objectives To study the contact allergenic activities of trichloroethylene (TCE) and its three metabolites trichloroacetic acid, trichloroethanol and chloral hydrate. Methods A modified guinea pig maximization test (GPMT) was adopted. The skin sensitization (edema and erythema) was observed in trichloroethylene, trichloroacetic acid, trichloroethanol, chloral hydrate and 2,4-dinitrochlorobenzene. Results The allergenic rate of TCE, trichloroacetic acid and 2,4-dinitrochlorobenzene was 71.4%, 58.3% and 100.0% respectively, and that of trichloroethanol and chloral hydrate was 0%. The mean response score of TCE, trichloroacetic acid and 2,4-dinitrochlorobenzene was 2.3, 1.1, 6.0 respectively. The histopathological analysis also showed an induction of allergenic transfomation in guinea pig skin by both TCE and trichloroacetic acid. Conclusion TCE appears to be a strong allergen while trichloroacetic acid a moderate one. On the other hand, both trichloroethanol and chloral hydrate are weak sensitization potentials. Immunologic reaction induced by TCE might be postulated as the pathological process of this illness. Consequently, it is suggested that in the mechanism of Occupational Dermatitis Medicamentose-Like (ODML) induced by TCE, the chemical itself might be the main cause of allergy. As one of its metabolic products, trichloroacetic acid might be a subordinate factor.

TANG XIAO-JIANG, LI LAI-YU, HUANG Jian-xun, DENG YING-YU. Guinea Pig Maximization Test for Trichloroethylene and Its Metabolites[J]. Biomedical and Environmental Sciences, 2002, 15(2): 113-118.
Citation: TANG XIAO-JIANG, LI LAI-YU, HUANG Jian-xun, DENG YING-YU. Guinea Pig Maximization Test for Trichloroethylene and Its Metabolites[J]. Biomedical and Environmental Sciences, 2002, 15(2): 113-118.

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