A Case-control Study on Children with Guillain-barre Syndrome in North China

GAI-FEN LIU; ZHENG-LAI WU; HU-SHENG WU; QUAN-YI WANG; GE-TU ZHAO-RI; CHUN-YONG WANG; ZHI-XUE LIANG; SHU-LAN CUI; JIAN-DE ZHENG

PDF
Cite
Share

facebook

twitter

google

linkedin

Volume 16 Issue 2

Jun. 2003

Turn off MathJax

Article Contents

Article Navigation > Biomedical and Environmental Sciences > 2003 > 16(2): 105-111

GAI-FEN LIU, ZHENG-LAI WU, HU-SHENG WU, QUAN-YI WANG, GE-TU ZHAO-RI, CHUN-YONG WANG, ZHI-XUE LIANG, SHU-LAN CUI, JIAN-DE ZHENG. A Case-control Study on Children with Guillain-barre Syndrome in North China[J]. Biomedical and Environmental Sciences, 2003, 16(2): 105-111.

Citation:

GAI-FEN LIU, ZHENG-LAI WU, HU-SHENG WU, QUAN-YI WANG, GE-TU ZHAO-RI, CHUN-YONG WANG, ZHI-XUE LIANG, SHU-LAN CUI, JIAN-DE ZHENG. A Case-control Study on Children with Guillain-barre Syndrome in North China[J]. Biomedical and Environmental Sciences, 2003, 16(2): 105-111.

A Case-control Study on Children with Guillain-barre Syndrome in North China

Department of Epidemiology, School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100005, China
Department of Neurology, Beijing Children's Hospital, Beijing 100045, China
Department of Epidemiology, Norman Bethune University of Medical Sciences, Changchun 130021, China
Department of Pediatrics, First Hospital Affiliated to Norman Bethune University of Medical Sciences, Changchun 130021, China
Department of Pediatrics, First Hospital Affiliated to Inner Mongolia Medical College, Huhehot 010050, China

Funds: This study was supported by the Rockefeller Foundation in the United States(Grant HS 9430)

Abstract

Objective To explore the risk factors for Guillain-barre syndrome. Methods Case-controlstudy design was used in 51 cases of Guillain-barre syndrome, and 51 matched controls. All of the 51cases in this study had been examined by electrophysiology. Serum IgG antibodies specific for C.jejuni were determined in all the subjects by ELISA. Each case and control were interviewed using anad hoc questionnaire, including his/her demographic information, onset of the illness, their personalhygiene and so on. Results The study showed that Guillain-barre syndrome was associated witha few factors, such as polio vaccine immunization before onset of illness (0R=7.27), no hand washingafter defecation and before meals (OR=6.15). Infection of C. jejuni was strongly associated with theillness (0R=9.5, P＜0.001). Conclusion It is suggested that occurrence of Guillain-barre syndromemay correlate to infection of C. jejuni and poor personal hygiene in children.
- Guillain-Barre syndrome (GBS),
- Case-control study,
- Campylobacter jejuni
References
Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Get Citation

PDF

XML

Article Metrics

Article views(1271) PDF downloads(31) Cited by()

Proportional views

A Case-control Study on Children with Guillain-barre Syndrome in North China

Department of Epidemiology, School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100005, China

Department of Neurology, Beijing Children's Hospital, Beijing 100045, China

Department of Epidemiology, Norman Bethune University of Medical Sciences, Changchun 130021, China

Department of Pediatrics, First Hospital Affiliated to Norman Bethune University of Medical Sciences, Changchun 130021, China

Department of Pediatrics, First Hospital Affiliated to Inner Mongolia Medical College, Huhehot 010050, China

Funds: This study was supported by the Rockefeller Foundation in the United States(Grant HS 9430)

Key words:

Abstract: Objective To explore the risk factors for Guillain-barre syndrome. Methods Case-controlstudy design was used in 51 cases of Guillain-barre syndrome, and 51 matched controls. All of the 51cases in this study had been examined by electrophysiology. Serum IgG antibodies specific for C.jejuni were determined in all the subjects by ELISA. Each case and control were interviewed using anad hoc questionnaire, including his/her demographic information, onset of the illness, their personalhygiene and so on. Results The study showed that Guillain-barre syndrome was associated witha few factors, such as polio vaccine immunization before onset of illness (0R=7.27), no hand washingafter defecation and before meals (OR=6.15). Infection of C. jejuni was strongly associated with theillness (0R=9.5, P＜0.001). Conclusion It is suggested that occurrence of Guillain-barre syndromemay correlate to infection of C. jejuni and poor personal hygiene in children.

Citation:

GAI-FEN LIU, ZHENG-LAI WU, HU-SHENG WU, QUAN-YI WANG, GE-TU ZHAO-RI, CHUN-YONG WANG, ZHI-XUE LIANG, SHU-LAN CUI, JIAN-DE ZHENG. A Case-control Study on Children with Guillain-barre Syndrome in North China[J]. Biomedical and Environmental Sciences, 2003, 16(2): 105-111.