Volume 22 Issue 5
Oct.  2009
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DONG-SHENG HU, JING XIE, DA-HAI YU, GUO-HENG XU, JIE LU, JIN-XIU YANG, CHUN-YANG LI, YAN-YAN LI. Perilipin Gene 1237 T>C Polymorphism is not Associated with Obesity Risk in Northern Chinese Han Adults[J]. Biomedical and Environmental Sciences, 2009, 22(5): 442-447.
Citation: DONG-SHENG HU, JING XIE, DA-HAI YU, GUO-HENG XU, JIE LU, JIN-XIU YANG, CHUN-YANG LI, YAN-YAN LI. Perilipin Gene 1237 T>C Polymorphism is not Associated with Obesity Risk in Northern Chinese Han Adults[J]. Biomedical and Environmental Sciences, 2009, 22(5): 442-447.

Perilipin Gene 1237 T>C Polymorphism is not Associated with Obesity Risk in Northern Chinese Han Adults

Funds:  the National Science Foundation of China(30671805)%Henan Innovation Project for University Prominent Research Talents(2006KYCX010)
  • Objective To identify the association between PLIN 1237 polymorphism and obesity in Chinese Han adults. Methods A total of 994 adults (157 obese subjects, 322 overweight subjects, and 515 normal controls) were recruited from two rural communities. PLIN 1237 polymorphism was genotyped by polymerase chain reaction-restriction-fragment-length-polymorphism (PCR-RFLP). Association between PLIN polymorphisms and obesity status was estimated by ordinal logistic regression. Results The three genotypes of PLIN 1237 were detected with a percentage of 54.3%, 37.1%, and 8.6% in TT, TC, and CC genotypes, respectively. For the PLIN 1237 polymorphism locus, the frequency of alleles T and C was 0.73 and 0.27, respectively. The PLIN 1237 polymorphisms were in Hardy-Weinberg equilibrium. PLIN 1237 polymorphism was not associated with obesity. The odds ratio for overweight or obesity for the CC+TC genotype was 0.8 (0.4, 1.4) in women (P=0.4) and 0.6 (0.3, 1.3) in men (P=0.2) after adjustment for age, education, household income and alcohol consumption, smoking, and physical activity. Conclusion Chinese Han adults have a lower frequency of variant-allele C in PLIN 1237. PLIN 1237 T>C polymorphism is not significantly associated with obesity in northern Chinese adults.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Perilipin Gene 1237 T>C Polymorphism is not Associated with Obesity Risk in Northern Chinese Han Adults

Funds:  the National Science Foundation of China(30671805)%Henan Innovation Project for University Prominent Research Talents(2006KYCX010)

Abstract: Objective To identify the association between PLIN 1237 polymorphism and obesity in Chinese Han adults. Methods A total of 994 adults (157 obese subjects, 322 overweight subjects, and 515 normal controls) were recruited from two rural communities. PLIN 1237 polymorphism was genotyped by polymerase chain reaction-restriction-fragment-length-polymorphism (PCR-RFLP). Association between PLIN polymorphisms and obesity status was estimated by ordinal logistic regression. Results The three genotypes of PLIN 1237 were detected with a percentage of 54.3%, 37.1%, and 8.6% in TT, TC, and CC genotypes, respectively. For the PLIN 1237 polymorphism locus, the frequency of alleles T and C was 0.73 and 0.27, respectively. The PLIN 1237 polymorphisms were in Hardy-Weinberg equilibrium. PLIN 1237 polymorphism was not associated with obesity. The odds ratio for overweight or obesity for the CC+TC genotype was 0.8 (0.4, 1.4) in women (P=0.4) and 0.6 (0.3, 1.3) in men (P=0.2) after adjustment for age, education, household income and alcohol consumption, smoking, and physical activity. Conclusion Chinese Han adults have a lower frequency of variant-allele C in PLIN 1237. PLIN 1237 T>C polymorphism is not significantly associated with obesity in northern Chinese adults.

DONG-SHENG HU, JING XIE, DA-HAI YU, GUO-HENG XU, JIE LU, JIN-XIU YANG, CHUN-YANG LI, YAN-YAN LI. Perilipin Gene 1237 T>C Polymorphism is not Associated with Obesity Risk in Northern Chinese Han Adults[J]. Biomedical and Environmental Sciences, 2009, 22(5): 442-447.
Citation: DONG-SHENG HU, JING XIE, DA-HAI YU, GUO-HENG XU, JIE LU, JIN-XIU YANG, CHUN-YANG LI, YAN-YAN LI. Perilipin Gene 1237 T>C Polymorphism is not Associated with Obesity Risk in Northern Chinese Han Adults[J]. Biomedical and Environmental Sciences, 2009, 22(5): 442-447.

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