Volume 22 Issue 5
Oct.  2009
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YU-MEI ZHANG, XUE-ZHONG LIU, HAO LU, LI MEI, ZONG-PING LIU. Lipid Peroxidation and Ultrastructural Modifications in Brain after Perinatal Exposure to Lead and/or Cadmium in Rat Pups[J]. Biomedical and Environmental Sciences, 2009, 22(5): 423-429.
Citation: YU-MEI ZHANG, XUE-ZHONG LIU, HAO LU, LI MEI, ZONG-PING LIU. Lipid Peroxidation and Ultrastructural Modifications in Brain after Perinatal Exposure to Lead and/or Cadmium in Rat Pups[J]. Biomedical and Environmental Sciences, 2009, 22(5): 423-429.

Lipid Peroxidation and Ultrastructural Modifications in Brain after Perinatal Exposure to Lead and/or Cadmium in Rat Pups

Funds:  国家自然科学基金(30440050%305713647)
  • Objective To assess lipid peroxidation and ultrastructural modifications in rat brains following perinatal exposure to lead (Pb) and/or cadmium (Cd). Methods Female rats were divided into four groups: control group, Pb (300 mg/L) group, Cd group (10 mg/L) and Pb+Cd (300 mg/L, 10 mg/L) group. The compounds were delivered in the drinking water throughout pregnancy and lactation. Results The levels of compounds in blood and brain of the Pb+Cd group were similar to those of other groups, but the effects of Pb+Cd on pups' body and brain weights were higher than on other compounds. Electron microscopy revealed that Pb and Cd had effects on mitochondrial swelling, disruption and cristae loss, Nissl body dissolution, degenerated organelles and vacuoles, cytomembrane disappearance, and nuclear ehromoplasm concentration. The activity of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT), acetylcholinesterase (ACHE) was decreased, whereas the activity of maleic dialdehyde (MDA) was increased. Conclusion Perinatal exposure to low doses of Pb and Cd can produce alterations in lipid peroxidation and ultrastructural modifications in rat brains, and exposure to both metals can result in greater damages.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Lipid Peroxidation and Ultrastructural Modifications in Brain after Perinatal Exposure to Lead and/or Cadmium in Rat Pups

Funds:  国家自然科学基金(30440050%305713647)

Abstract: Objective To assess lipid peroxidation and ultrastructural modifications in rat brains following perinatal exposure to lead (Pb) and/or cadmium (Cd). Methods Female rats were divided into four groups: control group, Pb (300 mg/L) group, Cd group (10 mg/L) and Pb+Cd (300 mg/L, 10 mg/L) group. The compounds were delivered in the drinking water throughout pregnancy and lactation. Results The levels of compounds in blood and brain of the Pb+Cd group were similar to those of other groups, but the effects of Pb+Cd on pups' body and brain weights were higher than on other compounds. Electron microscopy revealed that Pb and Cd had effects on mitochondrial swelling, disruption and cristae loss, Nissl body dissolution, degenerated organelles and vacuoles, cytomembrane disappearance, and nuclear ehromoplasm concentration. The activity of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT), acetylcholinesterase (ACHE) was decreased, whereas the activity of maleic dialdehyde (MDA) was increased. Conclusion Perinatal exposure to low doses of Pb and Cd can produce alterations in lipid peroxidation and ultrastructural modifications in rat brains, and exposure to both metals can result in greater damages.

YU-MEI ZHANG, XUE-ZHONG LIU, HAO LU, LI MEI, ZONG-PING LIU. Lipid Peroxidation and Ultrastructural Modifications in Brain after Perinatal Exposure to Lead and/or Cadmium in Rat Pups[J]. Biomedical and Environmental Sciences, 2009, 22(5): 423-429.
Citation: YU-MEI ZHANG, XUE-ZHONG LIU, HAO LU, LI MEI, ZONG-PING LIU. Lipid Peroxidation and Ultrastructural Modifications in Brain after Perinatal Exposure to Lead and/or Cadmium in Rat Pups[J]. Biomedical and Environmental Sciences, 2009, 22(5): 423-429.

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