Antitumorigenic Potential of Diallyl Sulfide in Ehrlich Ascites Tumor Bearing Mice

YOGESHWER SHUKLA; ANNU ARORA; ALKASINGH

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Volume 15 Issue 1

Mar. 2002

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Article Navigation > Biomedical and Environmental Sciences > 2002 > 15(1): 41-47

YOGESHWER SHUKLA, ANNU ARORA, ALKASINGH. Antitumorigenic Potential of Diallyl Sulfide in Ehrlich Ascites Tumor Bearing Mice[J]. Biomedical and Environmental Sciences, 2002, 15(1): 41-47.

Citation:

YOGESHWER SHUKLA, ANNU ARORA, ALKASINGH. Antitumorigenic Potential of Diallyl Sulfide in Ehrlich Ascites Tumor Bearing Mice[J]. Biomedical and Environmental Sciences, 2002, 15(1): 41-47.

Antitumorigenic Potential of Diallyl Sulfide in Ehrlich Ascites Tumor Bearing Mice

Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, M. G. Marg, P. O. Box 80, Lucknow-226001, India

Abstract

To study the effects of diallyl sulfide (DAS), an organosulfur compound present in garlic (Allium sativum),on the life span ofehrlich ascites (EA) tumor bearing Swiss albino mice, cytotoxicity and angiogenesis. Methods EA tumor cells were maintained by serial transplantation in peritoneal cavity of male Swiss albino mice. EA tumor cells were inoculated at concentrations of 1 × 106EA cells, 2.5 × l06EAcells and 5 × 106 EA cells. DAS was given in 0.2 mi normal saline i. p., daily for seven days followed one hour later by inoculation with EA cells in respective groups. Results The results revealed that administration of DAS increased the life span of EA tumor bearing animals by more than 25 percent. A significant dose dependant cytotoxic response of DAS was also observed on EA tumor cells. DAS was also found to inhibit the angiogenesis in EA tumor bearing mice in a dose dependent manner. Conclusion It is suggested that DAS may exert its anticarcinogenic effects by more than one mechanism and is a useful chemopreventive and chemotherapeutic agent.
- Garlic,
- Life span,
- Ehrlich ascites,
- EA tumor cells,
- Cytotoxicity,
- Angiogenesis
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Antitumorigenic Potential of Diallyl Sulfide in Ehrlich Ascites Tumor Bearing Mice

Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, M. G. Marg, P. O. Box 80, Lucknow-226001, India

Key words:

Abstract: To study the effects of diallyl sulfide (DAS), an organosulfur compound present in garlic (Allium sativum),on the life span ofehrlich ascites (EA) tumor bearing Swiss albino mice, cytotoxicity and angiogenesis. Methods EA tumor cells were maintained by serial transplantation in peritoneal cavity of male Swiss albino mice. EA tumor cells were inoculated at concentrations of 1 × 106EA cells, 2.5 × l06EAcells and 5 × 106 EA cells. DAS was given in 0.2 mi normal saline i. p., daily for seven days followed one hour later by inoculation with EA cells in respective groups. Results The results revealed that administration of DAS increased the life span of EA tumor bearing animals by more than 25 percent. A significant dose dependant cytotoxic response of DAS was also observed on EA tumor cells. DAS was also found to inhibit the angiogenesis in EA tumor bearing mice in a dose dependent manner. Conclusion It is suggested that DAS may exert its anticarcinogenic effects by more than one mechanism and is a useful chemopreventive and chemotherapeutic agent.

YOGESHWER SHUKLA, ANNU ARORA, ALKASINGH. Antitumorigenic Potential of Diallyl Sulfide in Ehrlich Ascites Tumor Bearing Mice[J]. Biomedical and Environmental Sciences, 2002, 15(1): 41-47.

Citation:

YOGESHWER SHUKLA, ANNU ARORA, ALKASINGH. Antitumorigenic Potential of Diallyl Sulfide in Ehrlich Ascites Tumor Bearing Mice[J]. Biomedical and Environmental Sciences, 2002, 15(1): 41-47.