Volume 19 Issue 2
Apr.  2006
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HONG-QUAN LI, ZHUO LI, YING LIU, JUN-HONG LI, JIAN-QUN DONG, JI-RONG GAO, CHUN-YAN GOU, HUI LI. Association of-238G/A and -857C/T Polymorphisms of Tumor Necrosis Factor-Alpha Gene Promoter Region With Outcomes of Hepatitis B Virus Infection[J]. Biomedical and Environmental Sciences, 2006, 19(2): 133-136.
Citation: HONG-QUAN LI, ZHUO LI, YING LIU, JUN-HONG LI, JIAN-QUN DONG, JI-RONG GAO, CHUN-YAN GOU, HUI LI. Association of-238G/A and -857C/T Polymorphisms of Tumor Necrosis Factor-Alpha Gene Promoter Region With Outcomes of Hepatitis B Virus Infection[J]. Biomedical and Environmental Sciences, 2006, 19(2): 133-136.

Association of-238G/A and -857C/T Polymorphisms of Tumor Necrosis Factor-Alpha Gene Promoter Region With Outcomes of Hepatitis B Virus Infection

Funds:  北京市科委科研项目(H020920020590)
  • To determine whether -238G/A and -857C/T polymorphisms of tumor necrosis factor-alpha (TNF-α) gene promoter were associated with outcomes of hepatitis B virus infection. Methods A total of 246 HBV self-limited infected subjects and 443 chronic hepatitis B (HB) patients were recruited in this case-control study. TNF-α-238G/A and -857C/T gene promoter polymorphisms were examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).Results The frequency of TNF-α-238 GG (90.7%) in chronic HB group was significantly lower than that (95.1%) in self-limited group (P=0.041). The frequency of TNF-α-857 CC (79.7%) in chronic HB patients was significantly higher than that (70.9%) in self-limited infected subjects (P=0.021). Multiple logistic regression analysis revealed that both TNF-α-238GA and -857CC were independently associated with chronic HB. Conclusions TNF-α promoter variants are likely to play a substantial role in influencing the outcomes of HBV infection.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Association of-238G/A and -857C/T Polymorphisms of Tumor Necrosis Factor-Alpha Gene Promoter Region With Outcomes of Hepatitis B Virus Infection

Funds:  北京市科委科研项目(H020920020590)

Abstract: To determine whether -238G/A and -857C/T polymorphisms of tumor necrosis factor-alpha (TNF-α) gene promoter were associated with outcomes of hepatitis B virus infection. Methods A total of 246 HBV self-limited infected subjects and 443 chronic hepatitis B (HB) patients were recruited in this case-control study. TNF-α-238G/A and -857C/T gene promoter polymorphisms were examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).Results The frequency of TNF-α-238 GG (90.7%) in chronic HB group was significantly lower than that (95.1%) in self-limited group (P=0.041). The frequency of TNF-α-857 CC (79.7%) in chronic HB patients was significantly higher than that (70.9%) in self-limited infected subjects (P=0.021). Multiple logistic regression analysis revealed that both TNF-α-238GA and -857CC were independently associated with chronic HB. Conclusions TNF-α promoter variants are likely to play a substantial role in influencing the outcomes of HBV infection.

HONG-QUAN LI, ZHUO LI, YING LIU, JUN-HONG LI, JIAN-QUN DONG, JI-RONG GAO, CHUN-YAN GOU, HUI LI. Association of-238G/A and -857C/T Polymorphisms of Tumor Necrosis Factor-Alpha Gene Promoter Region With Outcomes of Hepatitis B Virus Infection[J]. Biomedical and Environmental Sciences, 2006, 19(2): 133-136.
Citation: HONG-QUAN LI, ZHUO LI, YING LIU, JUN-HONG LI, JIAN-QUN DONG, JI-RONG GAO, CHUN-YAN GOU, HUI LI. Association of-238G/A and -857C/T Polymorphisms of Tumor Necrosis Factor-Alpha Gene Promoter Region With Outcomes of Hepatitis B Virus Infection[J]. Biomedical and Environmental Sciences, 2006, 19(2): 133-136.

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