Red Yeast Rice Increases Excretion of Bile Acids in Hamsters

KA-YING MA; ZE-SHENG ZHANG; SHU-XIN ZHAO; QI CHANG; YIN-MEI WONG; SAI YING VENUS YEUNG; YU HUANG; ZHEN-YU CHEN

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Volume 22 Issue 4

Aug. 2009

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Article Navigation > Biomedical and Environmental Sciences > 2009 > 22(4): 269-277

KA-YING MA, ZE-SHENG ZHANG, SHU-XIN ZHAO, QI CHANG, YIN-MEI WONG, SAI YING VENUS YEUNG, YU HUANG, ZHEN-YU CHEN. Red Yeast Rice Increases Excretion of Bile Acids in Hamsters[J]. Biomedical and Environmental Sciences, 2009, 22(4): 269-277.

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KA-YING MA, ZE-SHENG ZHANG, SHU-XIN ZHAO, QI CHANG, YIN-MEI WONG, SAI YING VENUS YEUNG, YU HUANG, ZHEN-YU CHEN. Red Yeast Rice Increases Excretion of Bile Acids in Hamsters[J]. Biomedical and Environmental Sciences, 2009, 22(4): 269-277.

Red Yeast Rice Increases Excretion of Bile Acids in Hamsters

Food and Nutritional Sciences Program, Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
Faculty of Food Engineering & Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
Institute of Medicinal Plant Development, Chinese Academy of Medical Science & Peking Union Medical College, Belting 100193, China
Department of Physiology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China

Abstract

Objectives To investigate the hypocholesterolemic activity of red yeast rice (RYR) and its underlying mechanism. Methods Three groups of hamsters were fed either the control diet or one of the two experimental diets containing by weight 0.1% RYR (0.1RYR) or 0.3% RYR (0.3RYR). Blood (0.5 mL) was collected from the retro-orbital sinus into a heparinized capillary tube at the end of week 0,3, and 6.Plasma lipoproteins were measured using enzymatic kits, while fecal neutral and acidic sterols were quantified using a gas-liquid chromatography. Results Plasma total cholesterol was reduced by 12% in 0.1RYR group and by 18% in 0.3RYR group compared with the control value. Similarly, plasma triacylglycerol was decreased by ll% in 0.1RYR group and by 24% in 0.3RYR group. Western blotting analysis demonstrated that RYR had no effect on sterol regulatory element binding protein 2, liver X receptor, 3-hydroxy-3-methylglutary-CoA reductase, LDL receptor, and cholesterol-7α-hydroxylase. HPLC analysis confirmed that RYR contained 0.88% monacolin K.It was recently found that RYR supplementation increased excretion of fecal acidic sterols by 3-4 folds compared with the control value. Conclusion Hypocholesterolemic activity of RYR is mediated at least partially by enhancement of acidic sterol excretion.
- Bile acid,
- Cholesterol,
- Monacolin,
- Red yeast rice,
- Triacylglcerols
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Red Yeast Rice Increases Excretion of Bile Acids in Hamsters

Food and Nutritional Sciences Program, Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China

Faculty of Food Engineering & Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China

Institute of Medicinal Plant Development, Chinese Academy of Medical Science & Peking Union Medical College, Belting 100193, China

Department of Physiology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China

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Abstract: Objectives To investigate the hypocholesterolemic activity of red yeast rice (RYR) and its underlying mechanism. Methods Three groups of hamsters were fed either the control diet or one of the two experimental diets containing by weight 0.1% RYR (0.1RYR) or 0.3% RYR (0.3RYR). Blood (0.5 mL) was collected from the retro-orbital sinus into a heparinized capillary tube at the end of week 0,3, and 6.Plasma lipoproteins were measured using enzymatic kits, while fecal neutral and acidic sterols were quantified using a gas-liquid chromatography. Results Plasma total cholesterol was reduced by 12% in 0.1RYR group and by 18% in 0.3RYR group compared with the control value. Similarly, plasma triacylglycerol was decreased by ll% in 0.1RYR group and by 24% in 0.3RYR group. Western blotting analysis demonstrated that RYR had no effect on sterol regulatory element binding protein 2, liver X receptor, 3-hydroxy-3-methylglutary-CoA reductase, LDL receptor, and cholesterol-7α-hydroxylase. HPLC analysis confirmed that RYR contained 0.88% monacolin K.It was recently found that RYR supplementation increased excretion of fecal acidic sterols by 3-4 folds compared with the control value. Conclusion Hypocholesterolemic activity of RYR is mediated at least partially by enhancement of acidic sterol excretion.

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