Volume 16 Issue 2
Nov.  2019
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GAI-FEN LIU, ZHENG-LAI WU, HU-SHENG WU, QUAN-YI WANG, GE-TU ZHAO-RI, CHUN-YONG WANG, ZHI-XUE LIANG, SHU-LAN CUI, JIAN-DE ZHENG. A Case-control Study on Children with Guillain-barre Syndrome in North China[J]. Biomedical and Environmental Sciences, 2003, 16(2): 105-111.
Citation: GAI-FEN LIU, ZHENG-LAI WU, HU-SHENG WU, QUAN-YI WANG, GE-TU ZHAO-RI, CHUN-YONG WANG, ZHI-XUE LIANG, SHU-LAN CUI, JIAN-DE ZHENG. A Case-control Study on Children with Guillain-barre Syndrome in North China[J]. Biomedical and Environmental Sciences, 2003, 16(2): 105-111.

A Case-control Study on Children with Guillain-barre Syndrome in North China

Funds:  This study was supported by the Rockefeller Foundation in the United States(Grant HS 9430)
  • Objective To explore the risk factors for Guillain-barre syndrome. Methods Case-controlstudy design was used in 51 cases of Guillain-barre syndrome, and 51 matched controls. All of the 51cases in this study had been examined by electrophysiology. Serum IgG antibodies specific for C.jejuni were determined in all the subjects by ELISA. Each case and control were interviewed using anad hoc questionnaire, including his/her demographic information, onset of the illness, their personalhygiene and so on. Results The study showed that Guillain-barre syndrome was associated witha few factors, such as polio vaccine immunization before onset of illness (0R=7.27), no hand washingafter defecation and before meals (OR=6.15). Infection of C. jejuni was strongly associated with theillness (0R=9.5, P<0.001). Conclusion It is suggested that occurrence of Guillain-barre syndromemay correlate to infection of C. jejuni and poor personal hygiene in children.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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A Case-control Study on Children with Guillain-barre Syndrome in North China

Funds:  This study was supported by the Rockefeller Foundation in the United States(Grant HS 9430)

Abstract: Objective To explore the risk factors for Guillain-barre syndrome. Methods Case-controlstudy design was used in 51 cases of Guillain-barre syndrome, and 51 matched controls. All of the 51cases in this study had been examined by electrophysiology. Serum IgG antibodies specific for C.jejuni were determined in all the subjects by ELISA. Each case and control were interviewed using anad hoc questionnaire, including his/her demographic information, onset of the illness, their personalhygiene and so on. Results The study showed that Guillain-barre syndrome was associated witha few factors, such as polio vaccine immunization before onset of illness (0R=7.27), no hand washingafter defecation and before meals (OR=6.15). Infection of C. jejuni was strongly associated with theillness (0R=9.5, P<0.001). Conclusion It is suggested that occurrence of Guillain-barre syndromemay correlate to infection of C. jejuni and poor personal hygiene in children.

GAI-FEN LIU, ZHENG-LAI WU, HU-SHENG WU, QUAN-YI WANG, GE-TU ZHAO-RI, CHUN-YONG WANG, ZHI-XUE LIANG, SHU-LAN CUI, JIAN-DE ZHENG. A Case-control Study on Children with Guillain-barre Syndrome in North China[J]. Biomedical and Environmental Sciences, 2003, 16(2): 105-111.
Citation: GAI-FEN LIU, ZHENG-LAI WU, HU-SHENG WU, QUAN-YI WANG, GE-TU ZHAO-RI, CHUN-YONG WANG, ZHI-XUE LIANG, SHU-LAN CUI, JIAN-DE ZHENG. A Case-control Study on Children with Guillain-barre Syndrome in North China[J]. Biomedical and Environmental Sciences, 2003, 16(2): 105-111.

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