SUN XiaoMing; LIU YeWei; WANG ZhenQuan; LI HongBing; LIU Yun; DI DuoLong

doi:10.3967/0895-3988.2011.03.003

doi: 10.3967/0895-3988.2011.03.003

基金项目: the Hundred Talents Program of the Chinese Academy of Sciences (CAS) in 2007%the National Natural Sciences Foundation of China(20775083)

Effect of Occupational Manganese Exposure on Uric Acid Levels in Human Urine

Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, Gansu, China;Graduate University of the Chinese Academy of Sciences, Beijing 100049, China
Institute of Nutrition and Food Hygiene, School of Public Health, Lanzhou University, Lanzhou 730000, Gansu, China
Graduate University of the Chinese Academy of Sciences, Beijing 100049, China

Funds: the Hundred Talents Program of the Chinese Academy of Sciences (CAS) in 2007%the National Natural Sciences Foundation of China(20775083)

摘要: Objective To investigate the effect of long-term and low-level occupational Mn exposure on the level of uric acid (UA) in human urine.Methods In this study, 65 volunteers were recruited, who were working on welding and foundry work in an plant in Gansu province, China. Additionally, 29 control samples were collected from individuals who did not have any history of excessive Mn exposure. An improved high performance liquid chromatography system equipped with a diode-array detector (HPLC-DAD) method was developed to determine the UA level in human urine. A Spectra AA 220 Atomic Absorption Spectrophotometer (AAS) was used to measure the Mn level in the urine.Results The analytical method was validated for concentrations ranging from 3.82-45.84 μg/mL with acceptable accuracy, precision, and recovery. Overall, the UA levels of Mn exposure samples were significantly lower than that of control samples (P<0.05).Conclusion The practical method developed here is suitable for both routine monitoring of UA level in human urine and metabolism research. Long-term and low-level occupational Mn exposure may lead to a lower UA level in urine, and UA might be an indicator of the early stage of manganism.
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Abstract: Objective To investigate the effect of long-term and low-level occupational Mn exposure on the level of uric acid (UA) in human urine.Methods In this study, 65 volunteers were recruited, who were working on welding and foundry work in an plant in Gansu province, China. Additionally, 29 control samples were collected from individuals who did not have any history of excessive Mn exposure. An improved high performance liquid chromatography system equipped with a diode-array detector (HPLC-DAD) method was developed to determine the UA level in human urine. A Spectra AA 220 Atomic Absorption Spectrophotometer (AAS) was used to measure the Mn level in the urine.Results The analytical method was validated for concentrations ranging from 3.82-45.84 μg/mL with acceptable accuracy, precision, and recovery. Overall, the UA levels of Mn exposure samples were significantly lower than that of control samples (P<0.05).Conclusion The practical method developed here is suitable for both routine monitoring of UA level in human urine and metabolism research. Long-term and low-level occupational Mn exposure may lead to a lower UA level in urine, and UA might be an indicator of the early stage of manganism.
- High-performance liquid chromatography /
- Uric acid /
- Occupational Mn exposure

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doi: 10.3967/0895-3988.2011.03.003

Effect of Occupational Manganese Exposure on Uric Acid Levels in Human Urine

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doi: 10.3967/0895-3988.2011.03.003

Effect of Occupational Manganese Exposure on Uric Acid Levels in Human Urine

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Effect of Occupational Manganese Exposure on Uric Acid Levels in Human Urine

doi: 10.3967/0895-3988.2011.03.003

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Effect of Occupational Manganese Exposure on Uric Acid Levels in Human Urine

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