Establishment of Occupational Exposure Limit for Warfarin in China

XU Jian Ning; FU Zhao Hui; YU Wen Lan; WANG Quan Kai; TAN Feng

doi:10.3967/0895-3988.2013.06.015

XU Jian Ning, FU Zhao Hui, YU Wen Lan, WANG Quan Kai, TAN Feng

文章导航 > Biomedical and Environmental Sciences > 2013 > 26(6): 513-516

XU Jian Ning, FU Zhao Hui, YU Wen Lan, WANG Quan Kai, TAN Feng. Establishment of Occupational Exposure Limit for Warfarin in China[J]. Biomedical and Environmental Sciences, 2013, 26(6): 513-516. doi: 10.3967/0895-3988.2013.06.015

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XU Jian Ning, FU Zhao Hui, YU Wen Lan, WANG Quan Kai, TAN Feng. Establishment of Occupational Exposure Limit for Warfarin in China[J]. Biomedical and Environmental Sciences, 2013, 26(6): 513-516. doi: 10.3967/0895-3988.2013.06.015

Establishment of Occupational Exposure Limit for Warfarin in China

doi: 10.3967/0895-3988.2013.06.015

1.National Institute of Occupational Health and Poison Control, Chinese Centers for Disease Control and Prevention, Beijing 100050, China;
2. Key Laboratory of Chemical Safety and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China

Establishment of Occupational Exposure Limit for Warfarin in China

1.National Institute of Occupational Health and Poison Control, Chinese Centers for Disease Control and Prevention, Beijing 100050, China;
2. Key Laboratory of Chemical Safety and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China

摘要:
This study aims to establish the occupational exposure limit (OEL) in the air for workplace of warfarin based on the available toxicological studies and field investigations by using questionnaire and air monitoring. The clinical therapeutic dose was used as lowest observed effect level (LOEL), and no observed effect level (NOEL) was achieved by using a safety factor. The highest concentration of warfarin monitored in the worksite of centrifuge washing, drying and packing were 0.029 mg/m3, 0.051 mg/m3 respectively, which did not exceed the OEL 0.1 mg/m3 recommended by NIOSH and ACGIH. Considering its feasibility for enforcement and protection for workers, we recommend OEL 0.1 mg/m3 of warfarin in China.

Abstract:
This study aims to establish the occupational exposure limit (OEL) in the air for workplace of warfarin based on the available toxicological studies and field investigations by using questionnaire and air monitoring. The clinical therapeutic dose was used as lowest observed effect level (LOEL), and no observed effect level (NOEL) was achieved by using a safety factor. The highest concentration of warfarin monitored in the worksite of centrifuge washing, drying and packing were 0.029 mg/m3, 0.051 mg/m3 respectively, which did not exceed the OEL 0.1 mg/m3 recommended by NIOSH and ACGIH. Considering its feasibility for enforcement and protection for workers, we recommend OEL 0.1 mg/m3 of warfarin in China.

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Establishment of Occupational Exposure Limit for Warfarin in China

doi: 10.3967/0895-3988.2013.06.015

1.National Institute of Occupational Health and Poison Control, Chinese Centers for Disease Control and Prevention, Beijing 100050, China;

2. Key Laboratory of Chemical Safety and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China

刊出日期: 2013-06-20

摘要:

This study aims to establish the occupational exposure limit (OEL) in the air for workplace of warfarin based on the available toxicological studies and field investigations by using questionnaire and air monitoring. The clinical therapeutic dose was used as lowest observed effect level (LOEL), and no observed effect level (NOEL) was achieved by using a safety factor. The highest concentration of warfarin monitored in the worksite of centrifuge washing, drying and packing were 0.029 mg/m3, 0.051 mg/m3 respectively, which did not exceed the OEL 0.1 mg/m3 recommended by NIOSH and ACGIH. Considering its feasibility for enforcement and protection for workers, we recommend OEL 0.1 mg/m3 of warfarin in China.