YANG HaiBo; XU ZhaoFa; LIU Wei; DENG Yu; XU Bin

doi:10.3967/0895-3988.2011.05.015

The Protective Role of Procyanidins and Lycopene Against Mercuric Chloride Renal Damage in Rats

YANG HaiBo, XU ZhaoFa, LIU Wei, DENG Yu, XU Bin

文章导航 > Biomedical and Environmental Sciences > 2011 > 24(5): 550-559

YANG HaiBo, XU ZhaoFa, LIU Wei, DENG Yu, XU Bin. The Protective Role of Procyanidins and Lycopene Against Mercuric Chloride Renal Damage in Rats[J]. Biomedical and Environmental Sciences, 2011, 24(5): 550-559. doi: 10.3967/0895-3988.2011.05.015

Citation:

YANG HaiBo, XU ZhaoFa, LIU Wei, DENG Yu, XU Bin. The Protective Role of Procyanidins and Lycopene Against Mercuric Chloride Renal Damage in Rats[J]. Biomedical and Environmental Sciences, 2011, 24(5): 550-559. doi: 10.3967/0895-3988.2011.05.015

doi: 10.3967/0895-3988.2011.05.015

The Protective Role of Procyanidins and Lycopene Against Mercuric Chloride Renal Damage in Rats

Department of Environmental Health, School of Public Health, China Medical University, Shenyang 110001,Liaoning, China

摘要: Objective This study aims to investigate the protection of procyanidins and lycopene from the renal damage induced by mercuric chloride.Methods Rats were treated with either procyanidins or lycopene 2h before HgCl2 subcutaneously injection,once daily treatment for 2 successive days.Results In comparison with HgCl2 group,markers of renal function such as blood urea nitrogen in serum and urinary protein were decreased to (18.45±11.63) mmol/L and (15.93±9.36) mmol/L,(4.54±0.78) g/(g·Cr) and (4.40±1.12) g/(g·Cr).N-acetyl-beta-D-glucosaminidase,lactate dehydrogenase,alkaline phosphatase in urine were depressed to (125.49±11.68) U/(g·Cr),(103.73±21.79) U/(g·Cr),(101.99±12.28) U/(g·Cr),and (113.19±23.74) U/(g·Cr),(71.14±21.80) U/(g·Cr),(73.64±21.51) U/(g·Cr)in procyanidins and lycopene groups.Indicators of oxidative stress,for example,Glutathion was reduced to (45.58±9.89) μmol/(g·pro) and (45.33±5.90) μmol/(g·pro),and antioxidant enzymes such as superoxide dismutase,glutathione-peroxidase were enhanced to (43.07±10.97) U/(mg·pro) and (39.94±6.04) U/(mg·pro),(83.85±18.48) U/(mg·pro),and (85.62±12.68) U/(mg·pro).Malondialdehyde was lowered to (0.95±0.12) (μmol/g·pro) and (1.03±0.12) μmol/(g·pro) in procyanidins and lycopene groups.ROS generation was decreased by 27.63％ and 16.40％ and apoptosis was also decreased in procyanidins and lycopene groups respectively.Pathological changes were much better as well.Conclusion Procyanidins and Lycopene play some protective role against mercury kidney damage.
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Abstract: Objective This study aims to investigate the protection of procyanidins and lycopene from the renal damage induced by mercuric chloride.Methods Rats were treated with either procyanidins or lycopene 2h before HgCl2 subcutaneously injection,once daily treatment for 2 successive days.Results In comparison with HgCl2 group,markers of renal function such as blood urea nitrogen in serum and urinary protein were decreased to (18.45±11.63) mmol/L and (15.93±9.36) mmol/L,(4.54±0.78) g/(g·Cr) and (4.40±1.12) g/(g·Cr).N-acetyl-beta-D-glucosaminidase,lactate dehydrogenase,alkaline phosphatase in urine were depressed to (125.49±11.68) U/(g·Cr),(103.73±21.79) U/(g·Cr),(101.99±12.28) U/(g·Cr),and (113.19±23.74) U/(g·Cr),(71.14±21.80) U/(g·Cr),(73.64±21.51) U/(g·Cr)in procyanidins and lycopene groups.Indicators of oxidative stress,for example,Glutathion was reduced to (45.58±9.89) μmol/(g·pro) and (45.33±5.90) μmol/(g·pro),and antioxidant enzymes such as superoxide dismutase,glutathione-peroxidase were enhanced to (43.07±10.97) U/(mg·pro) and (39.94±6.04) U/(mg·pro),(83.85±18.48) U/(mg·pro),and (85.62±12.68) U/(mg·pro).Malondialdehyde was lowered to (0.95±0.12) (μmol/g·pro) and (1.03±0.12) μmol/(g·pro) in procyanidins and lycopene groups.ROS generation was decreased by 27.63％ and 16.40％ and apoptosis was also decreased in procyanidins and lycopene groups respectively.Pathological changes were much better as well.Conclusion Procyanidins and Lycopene play some protective role against mercury kidney damage.
- Mercuric chloride /
- Procyanidins /
- Lycopene /
- Renal damage /
- Protection

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The Protective Role of Procyanidins and Lycopene Against Mercuric Chloride Renal Damage in Rats

doi: 10.3967/0895-3988.2011.05.015

刊出日期: 2011-10-20

关键词:

Lycopene /

摘要: Objective This study aims to investigate the protection of procyanidins and lycopene from the renal damage induced by mercuric chloride.Methods Rats were treated with either procyanidins or lycopene 2h before HgCl2 subcutaneously injection,once daily treatment for 2 successive days.Results In comparison with HgCl2 group,markers of renal function such as blood urea nitrogen in serum and urinary protein were decreased to (18.45±11.63) mmol/L and (15.93±9.36) mmol/L,(4.54±0.78) g/(g·Cr) and (4.40±1.12) g/(g·Cr).N-acetyl-beta-D-glucosaminidase,lactate dehydrogenase,alkaline phosphatase in urine were depressed to (125.49±11.68) U/(g·Cr),(103.73±21.79) U/(g·Cr),(101.99±12.28) U/(g·Cr),and (113.19±23.74) U/(g·Cr),(71.14±21.80) U/(g·Cr),(73.64±21.51) U/(g·Cr)in procyanidins and lycopene groups.Indicators of oxidative stress,for example,Glutathion was reduced to (45.58±9.89) μmol/(g·pro) and (45.33±5.90) μmol/(g·pro),and antioxidant enzymes such as superoxide dismutase,glutathione-peroxidase were enhanced to (43.07±10.97) U/(mg·pro) and (39.94±6.04) U/(mg·pro),(83.85±18.48) U/(mg·pro),and (85.62±12.68) U/(mg·pro).Malondialdehyde was lowered to (0.95±0.12) (μmol/g·pro) and (1.03±0.12) μmol/(g·pro) in procyanidins and lycopene groups.ROS generation was decreased by 27.63％ and 16.40％ and apoptosis was also decreased in procyanidins and lycopene groups respectively.Pathological changes were much better as well.Conclusion Procyanidins and Lycopene play some protective role against mercury kidney damage.

English Abstract

The Protective Role of Procyanidins and Lycopene Against Mercuric Chloride Renal Damage in Rats

Department of Environmental Health, School of Public Health, China Medical University, Shenyang 110001,Liaoning, China

Publish Date: 2011-10-20

Keywords:

Abstract: Objective This study aims to investigate the protection of procyanidins and lycopene from the renal damage induced by mercuric chloride.Methods Rats were treated with either procyanidins or lycopene 2h before HgCl2 subcutaneously injection,once daily treatment for 2 successive days.Results In comparison with HgCl2 group,markers of renal function such as blood urea nitrogen in serum and urinary protein were decreased to (18.45±11.63) mmol/L and (15.93±9.36) mmol/L,(4.54±0.78) g/(g·Cr) and (4.40±1.12) g/(g·Cr).N-acetyl-beta-D-glucosaminidase,lactate dehydrogenase,alkaline phosphatase in urine were depressed to (125.49±11.68) U/(g·Cr),(103.73±21.79) U/(g·Cr),(101.99±12.28) U/(g·Cr),and (113.19±23.74) U/(g·Cr),(71.14±21.80) U/(g·Cr),(73.64±21.51) U/(g·Cr)in procyanidins and lycopene groups.Indicators of oxidative stress,for example,Glutathion was reduced to (45.58±9.89) μmol/(g·pro) and (45.33±5.90) μmol/(g·pro),and antioxidant enzymes such as superoxide dismutase,glutathione-peroxidase were enhanced to (43.07±10.97) U/(mg·pro) and (39.94±6.04) U/(mg·pro),(83.85±18.48) U/(mg·pro),and (85.62±12.68) U/(mg·pro).Malondialdehyde was lowered to (0.95±0.12) (μmol/g·pro) and (1.03±0.12) μmol/(g·pro) in procyanidins and lycopene groups.ROS generation was decreased by 27.63％ and 16.40％ and apoptosis was also decreased in procyanidins and lycopene groups respectively.Pathological changes were much better as well.Conclusion Procyanidins and Lycopene play some protective role against mercury kidney damage.

Citation: