Volume 24 Issue 4
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ZHAO Lei, LIU QingJun, CHEN Hong, DUAN HuaWei, BIN Ping, LIU Qing, NIU Yong, DAI YuFei, ZHENG YuXin. The Effect of 2,5-hexanedione on Myelin Protein Zero Expression, and Its Mitigation Using Ginkgo Biloba Extract[J]. Biomedical and Environmental Sciences, 2011, 24(4): 374-382. doi: 10.3967/0895-3988.2011.04.008
Citation: ZHAO Lei, LIU QingJun, CHEN Hong, DUAN HuaWei, BIN Ping, LIU Qing, NIU Yong, DAI YuFei, ZHENG YuXin. The Effect of 2,5-hexanedione on Myelin Protein Zero Expression, and Its Mitigation Using Ginkgo Biloba Extract[J]. Biomedical and Environmental Sciences, 2011, 24(4): 374-382. doi: 10.3967/0895-3988.2011.04.008

The Effect of 2,5-hexanedione on Myelin Protein Zero Expression, and Its Mitigation Using Ginkgo Biloba Extract

doi: 10.3967/0895-3988.2011.04.008
Funds:  the National Nature Science Foundation of China(30700674%30625031)%the Project for Technologies of Occupational Health Surveillance and Detection(200902006)%the Youth Fund of Chinese Center of Disease Control(2010A204)
  • Objective To investigate the role of myelin protein zero (P0) in 2,5-hexanedione (2,5-HD)-induced peripheral nerve injury,and the protective effect of Ginkgo biloba extract (Egb761) on 2,5-HD-induced toxic peripheral neuropathy.Methods After 4 weeks of treatment with 2,5-HD at different doses (50,100,200,400 mg/kg) in rats,changes in the levels of P0 in rat sciatic nerves was investigated,and the effect of Egb761 on 2,5-HD-induced toxic peripheral neuropathy was studied.Results The blood-nerve barrier (BNB) permeability of the sciatic nerve increased,and the expression of P0 mRNA and P0 protein decreased in a dose-dependent manner after treatment with 2,5-HD for 4 weeks.Pretreatment with Egb761 protected against BNB interruption,and inhibited P0 mRNA and protein reduction during 2,5-HD treatment.Pretreatment with Egb761 significantly reduced loss of body weight (P<0.01) and mitigated gait abnormalities (2.85±0.22) induced by 400 mg/kg 2,5-HD (P<0.01).It also reduced the signs of neurotoxicity induced by 2,5-HD.Conclusion 2,5-HD inhibited the expression of P0 in a dose-dependent manner,and this may be an important mechanism by which toxic peripheral neuropathy is induced by 2,5-HD.Egb761 has a protective effect against 2,5-HD-induced peripheral neurotoxicity in rats.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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The Effect of 2,5-hexanedione on Myelin Protein Zero Expression, and Its Mitigation Using Ginkgo Biloba Extract

doi: 10.3967/0895-3988.2011.04.008
Funds:  the National Nature Science Foundation of China(30700674%30625031)%the Project for Technologies of Occupational Health Surveillance and Detection(200902006)%the Youth Fund of Chinese Center of Disease Control(2010A204)

Abstract: Objective To investigate the role of myelin protein zero (P0) in 2,5-hexanedione (2,5-HD)-induced peripheral nerve injury,and the protective effect of Ginkgo biloba extract (Egb761) on 2,5-HD-induced toxic peripheral neuropathy.Methods After 4 weeks of treatment with 2,5-HD at different doses (50,100,200,400 mg/kg) in rats,changes in the levels of P0 in rat sciatic nerves was investigated,and the effect of Egb761 on 2,5-HD-induced toxic peripheral neuropathy was studied.Results The blood-nerve barrier (BNB) permeability of the sciatic nerve increased,and the expression of P0 mRNA and P0 protein decreased in a dose-dependent manner after treatment with 2,5-HD for 4 weeks.Pretreatment with Egb761 protected against BNB interruption,and inhibited P0 mRNA and protein reduction during 2,5-HD treatment.Pretreatment with Egb761 significantly reduced loss of body weight (P<0.01) and mitigated gait abnormalities (2.85±0.22) induced by 400 mg/kg 2,5-HD (P<0.01).It also reduced the signs of neurotoxicity induced by 2,5-HD.Conclusion 2,5-HD inhibited the expression of P0 in a dose-dependent manner,and this may be an important mechanism by which toxic peripheral neuropathy is induced by 2,5-HD.Egb761 has a protective effect against 2,5-HD-induced peripheral neurotoxicity in rats.

ZHAO Lei, LIU QingJun, CHEN Hong, DUAN HuaWei, BIN Ping, LIU Qing, NIU Yong, DAI YuFei, ZHENG YuXin. The Effect of 2,5-hexanedione on Myelin Protein Zero Expression, and Its Mitigation Using Ginkgo Biloba Extract[J]. Biomedical and Environmental Sciences, 2011, 24(4): 374-382. doi: 10.3967/0895-3988.2011.04.008
Citation: ZHAO Lei, LIU QingJun, CHEN Hong, DUAN HuaWei, BIN Ping, LIU Qing, NIU Yong, DAI YuFei, ZHENG YuXin. The Effect of 2,5-hexanedione on Myelin Protein Zero Expression, and Its Mitigation Using Ginkgo Biloba Extract[J]. Biomedical and Environmental Sciences, 2011, 24(4): 374-382. doi: 10.3967/0895-3988.2011.04.008

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