Volume 27 Issue 5
Nov.  2019
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WU Jun, ZHAO Hui Ru, ZHANG Hui Ying, GE Yan Ling, QIU Shuang, ZHAO Jie, SONG Ying, ZHAO Jing Zhong, LU Song Song. Thrombin Generation Increasing with Age and Decreasing with Use of Heparin Indicated by Calibrated Automated Thrombogram Conducted in Chinese[J]. Biomedical and Environmental Sciences, 2014, 27(5): 378-384. doi: 10.3967/bes2014.063
Citation: WU Jun, ZHAO Hui Ru, ZHANG Hui Ying, GE Yan Ling, QIU Shuang, ZHAO Jie, SONG Ying, ZHAO Jing Zhong, LU Song Song. Thrombin Generation Increasing with Age and Decreasing with Use of Heparin Indicated by Calibrated Automated Thrombogram Conducted in Chinese[J]. Biomedical and Environmental Sciences, 2014, 27(5): 378-384. doi: 10.3967/bes2014.063

Thrombin Generation Increasing with Age and Decreasing with Use of Heparin Indicated by Calibrated Automated Thrombogram Conducted in Chinese

doi: 10.3967/bes2014.063
Funds:  This study was supported by grant from the Ministry of Education of China (grant 20110001120088)
  • Objective Calibrated Automated Thrombogram(CAT) is a test to monitor the generation of thrombin. It can be described by four parameters:lag time, peak thrombin, endogenous thrombin potential (ETP) and time to peak (ttPeak). This study aims to determine the normal ranges of CAT parameters in Chinese, and evaluate whether thrombin generation is correlated with the concentration of heparin/low molecular weight heparin.
    Methods Plasma from 120 healthy subjects were collected to determine the normal rangea of CAT parameters in Chinese. Normal plasma pool (NPP, n=25) spiked with different concentrations of heparin or enoxaparin were used to detecte CAT parameters. The overall and age specific normal ranges of CAT parameters were calculated using descriptive statistics method with mean±2SD. The correlation between CAT parameters and age or concentrations of heparin, enoxaparin were analyzed with linear regression model.
    Results The normal ranges for lag time, peak thrombin, ETP, ttPeak in the subjects were 3.648±2.465 min, 367.39±151.93 nmol/L, 2277±1030 nmol/L·min and 6.372±4.280 min respectively. Age was linearly correlated with lag time (r=-0.6583, P<0.0001), peak thrombin (r=0.4863, P<0.0001), ETP (r=0.3608, P<0.0014) and ttPeak (r=-0.6313, P<0.0001). The values of ETP/peak ratio were linearly correlated with concentrations of heparin.
    Conclusion The normal ranges of four CAT parameters for Chinese were determined. CAT parameters are associated with age. ETP/peak ratio could be used to monitor the process of anticoagulation therapy.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Thrombin Generation Increasing with Age and Decreasing with Use of Heparin Indicated by Calibrated Automated Thrombogram Conducted in Chinese

doi: 10.3967/bes2014.063
Funds:  This study was supported by grant from the Ministry of Education of China (grant 20110001120088)

Abstract: Objective Calibrated Automated Thrombogram(CAT) is a test to monitor the generation of thrombin. It can be described by four parameters:lag time, peak thrombin, endogenous thrombin potential (ETP) and time to peak (ttPeak). This study aims to determine the normal ranges of CAT parameters in Chinese, and evaluate whether thrombin generation is correlated with the concentration of heparin/low molecular weight heparin.
Methods Plasma from 120 healthy subjects were collected to determine the normal rangea of CAT parameters in Chinese. Normal plasma pool (NPP, n=25) spiked with different concentrations of heparin or enoxaparin were used to detecte CAT parameters. The overall and age specific normal ranges of CAT parameters were calculated using descriptive statistics method with mean±2SD. The correlation between CAT parameters and age or concentrations of heparin, enoxaparin were analyzed with linear regression model.
Results The normal ranges for lag time, peak thrombin, ETP, ttPeak in the subjects were 3.648±2.465 min, 367.39±151.93 nmol/L, 2277±1030 nmol/L·min and 6.372±4.280 min respectively. Age was linearly correlated with lag time (r=-0.6583, P<0.0001), peak thrombin (r=0.4863, P<0.0001), ETP (r=0.3608, P<0.0014) and ttPeak (r=-0.6313, P<0.0001). The values of ETP/peak ratio were linearly correlated with concentrations of heparin.
Conclusion The normal ranges of four CAT parameters for Chinese were determined. CAT parameters are associated with age. ETP/peak ratio could be used to monitor the process of anticoagulation therapy.

WU Jun, ZHAO Hui Ru, ZHANG Hui Ying, GE Yan Ling, QIU Shuang, ZHAO Jie, SONG Ying, ZHAO Jing Zhong, LU Song Song. Thrombin Generation Increasing with Age and Decreasing with Use of Heparin Indicated by Calibrated Automated Thrombogram Conducted in Chinese[J]. Biomedical and Environmental Sciences, 2014, 27(5): 378-384. doi: 10.3967/bes2014.063
Citation: WU Jun, ZHAO Hui Ru, ZHANG Hui Ying, GE Yan Ling, QIU Shuang, ZHAO Jie, SONG Ying, ZHAO Jing Zhong, LU Song Song. Thrombin Generation Increasing with Age and Decreasing with Use of Heparin Indicated by Calibrated Automated Thrombogram Conducted in Chinese[J]. Biomedical and Environmental Sciences, 2014, 27(5): 378-384. doi: 10.3967/bes2014.063

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