Volume 28 Issue 1
Nov.  2019
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LIN Yong Xin, DING Zhi Yong, ZHOU Xiao Bin, LI Si Tao, XIE De Ming, LI Zhi Zhong, SUN Guo Dong. In vitro and In vivo Evaluation of the Developed PLGA/HAp/Zein Scaffolds for Bone-Cartilage Interface Regeneration[J]. Biomedical and Environmental Sciences, 2015, 28(1): 1-12. doi: 10.3967/bes2015.001
Citation: LIN Yong Xin, DING Zhi Yong, ZHOU Xiao Bin, LI Si Tao, XIE De Ming, LI Zhi Zhong, SUN Guo Dong. In vitro and In vivo Evaluation of the Developed PLGA/HAp/Zein Scaffolds for Bone-Cartilage Interface Regeneration[J]. Biomedical and Environmental Sciences, 2015, 28(1): 1-12. doi: 10.3967/bes2015.001

In vitro and In vivo Evaluation of the Developed PLGA/HAp/Zein Scaffolds for Bone-Cartilage Interface Regeneration

doi: 10.3967/bes2015.001
Funds:  This research was financially supported by the National Natural Science Foundation of China, No.31070862%Science and Technology Plan of Guangzhou, No.12C32071662%Research Foundation of Guangdong Provincial Bureau of Traditional Chinese Medicine, No.2013113%scientific research and cultivating Foundation of the First Clinical Medical College of Jinan University, No.2012103 and No.2013208
  • Objective To investigate the effect of electronspun PLGA/HAp/Zein scaffolds on the repair of cartilage defects.
    Methods The PLGA/HAp/Zein composite scaffolds were fabricated by electrospinning method. The physiochemical properties and biocompatibility of the scaffolds were separately characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), and fourier transform infrared spectroscopy (FTIR), human umbilical cord mesenchymal stem cells (hUC-MSCs) culture and animal experiments.
    Results The prepared PLGA/HAp/Zein scaffolds showed fibrous structure with homogenous distribution. hUC-MSCs could attach to and grow well on PLGA/HAp/Zein scaffolds, and there was no significant difference between cell proliferation on scaffolds and that without scaffolds (P>0.05). The PLGA/HAp/Zein scaffolds possessed excellent ability to promote in vivo cartilage formation. Moreover, there was a large amount of immature chondrocytes and matrix with cartilage lacuna on PLGA/HAp/Zein scaffolds.
    Conclusion The data suggest that the PLGA/HAp/Zein scaffolds possess good biocompatibility, which are anticipated to be potentially applied in cartilage tissue engineering and reconstruction.
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通讯作者: 陈斌, bchen63@163.com
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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In vitro and In vivo Evaluation of the Developed PLGA/HAp/Zein Scaffolds for Bone-Cartilage Interface Regeneration

doi: 10.3967/bes2015.001
Funds:  This research was financially supported by the National Natural Science Foundation of China, No.31070862%Science and Technology Plan of Guangzhou, No.12C32071662%Research Foundation of Guangdong Provincial Bureau of Traditional Chinese Medicine, No.2013113%scientific research and cultivating Foundation of the First Clinical Medical College of Jinan University, No.2012103 and No.2013208

Abstract: Objective To investigate the effect of electronspun PLGA/HAp/Zein scaffolds on the repair of cartilage defects.
Methods The PLGA/HAp/Zein composite scaffolds were fabricated by electrospinning method. The physiochemical properties and biocompatibility of the scaffolds were separately characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), and fourier transform infrared spectroscopy (FTIR), human umbilical cord mesenchymal stem cells (hUC-MSCs) culture and animal experiments.
Results The prepared PLGA/HAp/Zein scaffolds showed fibrous structure with homogenous distribution. hUC-MSCs could attach to and grow well on PLGA/HAp/Zein scaffolds, and there was no significant difference between cell proliferation on scaffolds and that without scaffolds (P>0.05). The PLGA/HAp/Zein scaffolds possessed excellent ability to promote in vivo cartilage formation. Moreover, there was a large amount of immature chondrocytes and matrix with cartilage lacuna on PLGA/HAp/Zein scaffolds.
Conclusion The data suggest that the PLGA/HAp/Zein scaffolds possess good biocompatibility, which are anticipated to be potentially applied in cartilage tissue engineering and reconstruction.

LIN Yong Xin, DING Zhi Yong, ZHOU Xiao Bin, LI Si Tao, XIE De Ming, LI Zhi Zhong, SUN Guo Dong. In vitro and In vivo Evaluation of the Developed PLGA/HAp/Zein Scaffolds for Bone-Cartilage Interface Regeneration[J]. Biomedical and Environmental Sciences, 2015, 28(1): 1-12. doi: 10.3967/bes2015.001
Citation: LIN Yong Xin, DING Zhi Yong, ZHOU Xiao Bin, LI Si Tao, XIE De Ming, LI Zhi Zhong, SUN Guo Dong. In vitro and In vivo Evaluation of the Developed PLGA/HAp/Zein Scaffolds for Bone-Cartilage Interface Regeneration[J]. Biomedical and Environmental Sciences, 2015, 28(1): 1-12. doi: 10.3967/bes2015.001

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