Volume 28 Issue 9
Nov.  2019
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Faridah Yusof, Atheer Awad Mehde, Wesen Adel Mehdi, Raha Ahmed Raus, Hamid Ghazali, Azlina Abd Rahman. Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) Activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian Individuals[J]. Biomedical and Environmental Sciences, 2015, 28(9): 660-665. doi: 10.3967/bes2015.092
Citation: Faridah Yusof, Atheer Awad Mehde, Wesen Adel Mehdi, Raha Ahmed Raus, Hamid Ghazali, Azlina Abd Rahman. Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) Activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian Individuals[J]. Biomedical and Environmental Sciences, 2015, 28(9): 660-665. doi: 10.3967/bes2015.092

Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) Activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian Individuals

doi: 10.3967/bes2015.092
Funds:  This study was supported by grants from the International Islamic University Malaysia, the research management centre (IIUM/504/5/29/1)
  • Objective Nephrolithiasis is one of the most common disorders of the urinary tract. The aim of this study was to examine a possible relationship between DNase I/II activity and E3 SUMO-protein ligase NSE2 in the sera of nephrolithiasis patients to evaluate the possibility of a new biomarker for evaluating kidney damage.
    Methods Sixty nephrolithiasis patients and 50 control patients were enrolled in a case-control study. Their blood urea, creatinine, protein levels and DNase I/II activity levels were measured by spectrometry. Serum NSMCE2 levels were measured by ELISA. Blood was collected from patients of the government health clinics in Kuantan-Pahang and fulfilled the inclusion criteria.
    Results The result indicated that mean levels of sera NSMCE2 have a significantly increase (P<0.01) in patients compared to control group. Compared with control subjects, activities and specific activities of serum DNase I and II were significantly elevated in nephrolithiasis patients (P<0.01).
    Conclusion This study suggests that an increase in serum concentrations of DNase I/II and E3 SUMO-protein ligase NSE2 level can be used as indicators for the diagnosis of kidney injury in patients with nephrolithiasis.
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Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) Activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian Individuals

doi: 10.3967/bes2015.092
Funds:  This study was supported by grants from the International Islamic University Malaysia, the research management centre (IIUM/504/5/29/1)

Abstract: Objective Nephrolithiasis is one of the most common disorders of the urinary tract. The aim of this study was to examine a possible relationship between DNase I/II activity and E3 SUMO-protein ligase NSE2 in the sera of nephrolithiasis patients to evaluate the possibility of a new biomarker for evaluating kidney damage.
Methods Sixty nephrolithiasis patients and 50 control patients were enrolled in a case-control study. Their blood urea, creatinine, protein levels and DNase I/II activity levels were measured by spectrometry. Serum NSMCE2 levels were measured by ELISA. Blood was collected from patients of the government health clinics in Kuantan-Pahang and fulfilled the inclusion criteria.
Results The result indicated that mean levels of sera NSMCE2 have a significantly increase (P<0.01) in patients compared to control group. Compared with control subjects, activities and specific activities of serum DNase I and II were significantly elevated in nephrolithiasis patients (P<0.01).
Conclusion This study suggests that an increase in serum concentrations of DNase I/II and E3 SUMO-protein ligase NSE2 level can be used as indicators for the diagnosis of kidney injury in patients with nephrolithiasis.

Faridah Yusof, Atheer Awad Mehde, Wesen Adel Mehdi, Raha Ahmed Raus, Hamid Ghazali, Azlina Abd Rahman. Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) Activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian Individuals[J]. Biomedical and Environmental Sciences, 2015, 28(9): 660-665. doi: 10.3967/bes2015.092
Citation: Faridah Yusof, Atheer Awad Mehde, Wesen Adel Mehdi, Raha Ahmed Raus, Hamid Ghazali, Azlina Abd Rahman. Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) Activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian Individuals[J]. Biomedical and Environmental Sciences, 2015, 28(9): 660-665. doi: 10.3967/bes2015.092

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