Volume 15 Issue 4
Nov.  2019
Turn off MathJax
Article Contents

M.K.J.SIDDIQUI, S.SRIVASTAVA, P.K.MEHROTRA. Environmental Exposure to Lead as a Risk for Prostate Cancer[J]. Biomedical and Environmental Sciences, 2002, 15(4): 298-305.
Citation: M.K.J.SIDDIQUI, S.SRIVASTAVA, P.K.MEHROTRA. Environmental Exposure to Lead as a Risk for Prostate Cancer[J]. Biomedical and Environmental Sciences, 2002, 15(4): 298-305.

Environmental Exposure to Lead as a Risk for Prostate Cancer

  • Objective To evaluate the possible role of environmental exposure to lead as a risk factor for prostate pathology in patients suffering from prostate cancer (PCA) and benign prostate hyperplasia (BPH). Methods Blood lead (BPb) level was determined in PCA and BPH cases using a graphite furnace Atomic Absorption Spectrophotometer and compared with those in a control group living in the similar socioeconomic environment. Results BPb was significantly higher in PCA and BPH cases than in normals (P<0.05). Blood levels of zinc and copper were significantly lower in PCA and BPH cases when compared with controls (P<0.05). In all the three groups, a statistically significant positive correlation between lead and thiobarbituric acid reactive substances (TBARS) measured as malondialdehyde, and negative correlation between blood lead and antioxidant GSH level, indicative of possible generation of reactive oxygen species, were also observed after adjusting for age as a possible confounders. However, positive association between blood lead and TBARS was relatively higher in PCA patients (r=0.77, P<0.05) than in BPH (r=0.32, P<0.05) and normal (r=0.30, P<0.05).Conclusion These results with limited power seem to suggest for the first time that environmental exposure of aging males to lead may be a risk factor for prostate cancer and/or benign prostate hyperplasia possibly through generation of reactive oxygen species and/or reducing the level of zinc which acts as a cellular growth protector.
  • 加载中
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(599) PDF downloads(4) Cited by()

Proportional views
Related

Environmental Exposure to Lead as a Risk for Prostate Cancer

Abstract: Objective To evaluate the possible role of environmental exposure to lead as a risk factor for prostate pathology in patients suffering from prostate cancer (PCA) and benign prostate hyperplasia (BPH). Methods Blood lead (BPb) level was determined in PCA and BPH cases using a graphite furnace Atomic Absorption Spectrophotometer and compared with those in a control group living in the similar socioeconomic environment. Results BPb was significantly higher in PCA and BPH cases than in normals (P<0.05). Blood levels of zinc and copper were significantly lower in PCA and BPH cases when compared with controls (P<0.05). In all the three groups, a statistically significant positive correlation between lead and thiobarbituric acid reactive substances (TBARS) measured as malondialdehyde, and negative correlation between blood lead and antioxidant GSH level, indicative of possible generation of reactive oxygen species, were also observed after adjusting for age as a possible confounders. However, positive association between blood lead and TBARS was relatively higher in PCA patients (r=0.77, P<0.05) than in BPH (r=0.32, P<0.05) and normal (r=0.30, P<0.05).Conclusion These results with limited power seem to suggest for the first time that environmental exposure of aging males to lead may be a risk factor for prostate cancer and/or benign prostate hyperplasia possibly through generation of reactive oxygen species and/or reducing the level of zinc which acts as a cellular growth protector.

M.K.J.SIDDIQUI, S.SRIVASTAVA, P.K.MEHROTRA. Environmental Exposure to Lead as a Risk for Prostate Cancer[J]. Biomedical and Environmental Sciences, 2002, 15(4): 298-305.
Citation: M.K.J.SIDDIQUI, S.SRIVASTAVA, P.K.MEHROTRA. Environmental Exposure to Lead as a Risk for Prostate Cancer[J]. Biomedical and Environmental Sciences, 2002, 15(4): 298-305.

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return