Volume 17 Issue 4
Nov.  2019
Turn off MathJax
Article Contents

SEEMA JOSHI, S.K.HASAN, RAMESH CHANDRA, M.M.HUSAIN, R.C.SRIVASTAVA. Scavenging Action of Zinc and Green Tea Polyphenol on Cisplatin and Nickel Induced Nitric Oxide Generation and Lipid Peroxidation in Rats[J]. Biomedical and Environmental Sciences, 2004, 17(4): 402-409.
Citation: SEEMA JOSHI, S.K.HASAN, RAMESH CHANDRA, M.M.HUSAIN, R.C.SRIVASTAVA. Scavenging Action of Zinc and Green Tea Polyphenol on Cisplatin and Nickel Induced Nitric Oxide Generation and Lipid Peroxidation in Rats[J]. Biomedical and Environmental Sciences, 2004, 17(4): 402-409.

Scavenging Action of Zinc and Green Tea Polyphenol on Cisplatin and Nickel Induced Nitric Oxide Generation and Lipid Peroxidation in Rats

  • Toxic metal ions have been implicated in the generation of reactive oxygen species (ROS) and nitric oxide (NO). Metallothionines (MT) and plant flavonoids have been reported in the intervention against oxidative damage. We investigated the effect of zinc induced MT and green tea polyphenol (GTP) in reducing the oxidative responses induced by nickel and platinum. Methods Zinc (10 mg/kg b. wt, sc) was administered to rats twice at a gap of 24hrs and GTP (10 mg/100 mL in drinking water) was fed ad libitum for 8 days. Nickel chloride (150 umol/kgb.wt, ip) and cisplatin (50 (mol/kg b.wt, sc) was administered to rats 24 h after Zn or GTP pre-treatment. Animals of all the groups were sacrificed 16 hrs after treatment and biochemical markers for toxicity were monitored. Results Zinc or GTP pre-treatment caused significant protection against nickel or cisplatin enhanced mortality in rats, and reduction in lipid peroxidation and NO. Conclusion It is proposed that inhibition of ROS and NO by GTP and zinc may prove useful as a selective pharmacological agent in the amelioration of metal toxicity.
  • 加载中
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(814) PDF downloads(15) Cited by()

Proportional views
Related

Scavenging Action of Zinc and Green Tea Polyphenol on Cisplatin and Nickel Induced Nitric Oxide Generation and Lipid Peroxidation in Rats

Abstract: Toxic metal ions have been implicated in the generation of reactive oxygen species (ROS) and nitric oxide (NO). Metallothionines (MT) and plant flavonoids have been reported in the intervention against oxidative damage. We investigated the effect of zinc induced MT and green tea polyphenol (GTP) in reducing the oxidative responses induced by nickel and platinum. Methods Zinc (10 mg/kg b. wt, sc) was administered to rats twice at a gap of 24hrs and GTP (10 mg/100 mL in drinking water) was fed ad libitum for 8 days. Nickel chloride (150 umol/kgb.wt, ip) and cisplatin (50 (mol/kg b.wt, sc) was administered to rats 24 h after Zn or GTP pre-treatment. Animals of all the groups were sacrificed 16 hrs after treatment and biochemical markers for toxicity were monitored. Results Zinc or GTP pre-treatment caused significant protection against nickel or cisplatin enhanced mortality in rats, and reduction in lipid peroxidation and NO. Conclusion It is proposed that inhibition of ROS and NO by GTP and zinc may prove useful as a selective pharmacological agent in the amelioration of metal toxicity.

SEEMA JOSHI, S.K.HASAN, RAMESH CHANDRA, M.M.HUSAIN, R.C.SRIVASTAVA. Scavenging Action of Zinc and Green Tea Polyphenol on Cisplatin and Nickel Induced Nitric Oxide Generation and Lipid Peroxidation in Rats[J]. Biomedical and Environmental Sciences, 2004, 17(4): 402-409.
Citation: SEEMA JOSHI, S.K.HASAN, RAMESH CHANDRA, M.M.HUSAIN, R.C.SRIVASTAVA. Scavenging Action of Zinc and Green Tea Polyphenol on Cisplatin and Nickel Induced Nitric Oxide Generation and Lipid Peroxidation in Rats[J]. Biomedical and Environmental Sciences, 2004, 17(4): 402-409.

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return