Volume 19 Issue 4
Nov.  2019
Turn off MathJax
Article Contents

GUI-DONG DAI, LUN-BIAO CUI, LING SONG, RU LIU, JUN HE, YU-BANG WANG, JIAN-FENG CHENG, HEBRON C. CHANG, XIN-RU WANG. Effects of Terephthalic Acid on Rat Lipid Metabolism[J]. Biomedical and Environmental Sciences, 2006, 19(4): 273-276.
Citation: GUI-DONG DAI, LUN-BIAO CUI, LING SONG, RU LIU, JUN HE, YU-BANG WANG, JIAN-FENG CHENG, HEBRON C. CHANG, XIN-RU WANG. Effects of Terephthalic Acid on Rat Lipid Metabolism[J]. Biomedical and Environmental Sciences, 2006, 19(4): 273-276.

Effects of Terephthalic Acid on Rat Lipid Metabolism

Funds:  国家自然科学基金(30170798)%国家重点基础研究发展计划(973计划)(2001CCA04900)%the Greatest Project in the National Basic Research(2002CB512908)
  • To study the effect of terephthalic acid (TPA) on lipid metabolism in Sprague-Dawley (SD) rats. Methods Five groups of SD rats that ingested 0%, 0.04%, 0.2%, 1%, and 5% TPA, respectively, were included in a 90-day subchronic feeding study.Effects of TPA on levels of serum protein, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL), total antioxidative capability (T-AOC), superoxide dismutase (SOD) and malondialdehyde (MDA) were observed. Urine samples were collected and analyzed for concentration of ion. Results TPA decreased the level of serum T-AOC in a dose dependent manner. The contents of serum and bladder MDA significantly decreased in 1% and 5% TPA ingestion groups. Serum CuZn superoxide dismutase (CuZnSOD) lowered in groups of 0.2%, 1%, and 5% TPA. TPA subchronic feeding had no significant influences on serum TC, LDL or HDL, but increased serum TG, TP and ALB after administration of 0.04% and/or 0.2% TPA. Concentrations of urinary Ca2+, Mg2+, Na+,and K+ were elevated in 1% and 5% TPA groups. Conclusion Antioxidative potential decreased after TPA exposure. MDA increase in serum and bladder tissues was one of the most important reactions in rats which could protect themselves against TPA impairment.The decrease of serum CuZnSOD was related to the excretion of Zn2+.
  • 加载中
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(641) PDF downloads(9) Cited by()

Proportional views
Related

Effects of Terephthalic Acid on Rat Lipid Metabolism

Funds:  国家自然科学基金(30170798)%国家重点基础研究发展计划(973计划)(2001CCA04900)%the Greatest Project in the National Basic Research(2002CB512908)

Abstract: To study the effect of terephthalic acid (TPA) on lipid metabolism in Sprague-Dawley (SD) rats. Methods Five groups of SD rats that ingested 0%, 0.04%, 0.2%, 1%, and 5% TPA, respectively, were included in a 90-day subchronic feeding study.Effects of TPA on levels of serum protein, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL), total antioxidative capability (T-AOC), superoxide dismutase (SOD) and malondialdehyde (MDA) were observed. Urine samples were collected and analyzed for concentration of ion. Results TPA decreased the level of serum T-AOC in a dose dependent manner. The contents of serum and bladder MDA significantly decreased in 1% and 5% TPA ingestion groups. Serum CuZn superoxide dismutase (CuZnSOD) lowered in groups of 0.2%, 1%, and 5% TPA. TPA subchronic feeding had no significant influences on serum TC, LDL or HDL, but increased serum TG, TP and ALB after administration of 0.04% and/or 0.2% TPA. Concentrations of urinary Ca2+, Mg2+, Na+,and K+ were elevated in 1% and 5% TPA groups. Conclusion Antioxidative potential decreased after TPA exposure. MDA increase in serum and bladder tissues was one of the most important reactions in rats which could protect themselves against TPA impairment.The decrease of serum CuZnSOD was related to the excretion of Zn2+.

GUI-DONG DAI, LUN-BIAO CUI, LING SONG, RU LIU, JUN HE, YU-BANG WANG, JIAN-FENG CHENG, HEBRON C. CHANG, XIN-RU WANG. Effects of Terephthalic Acid on Rat Lipid Metabolism[J]. Biomedical and Environmental Sciences, 2006, 19(4): 273-276.
Citation: GUI-DONG DAI, LUN-BIAO CUI, LING SONG, RU LIU, JUN HE, YU-BANG WANG, JIAN-FENG CHENG, HEBRON C. CHANG, XIN-RU WANG. Effects of Terephthalic Acid on Rat Lipid Metabolism[J]. Biomedical and Environmental Sciences, 2006, 19(4): 273-276.

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return