Volume 17 Issue 4
Nov.  2019
Turn off MathJax
Article Contents

QIN-MEI WANG, YI-CHANG NI, Jian Guo, JIA-TONG WU, YING-JUN QIAN. Comparative Study on Schizontocidal Activity of Recrystallized or Crude Daphnetin Against Malaria Parasites[J]. Biomedical and Environmental Sciences, 2004, 17(4): 397-401.
Citation: QIN-MEI WANG, YI-CHANG NI, Jian Guo, JIA-TONG WU, YING-JUN QIAN. Comparative Study on Schizontocidal Activity of Recrystallized or Crude Daphnetin Against Malaria Parasites[J]. Biomedical and Environmental Sciences, 2004, 17(4): 397-401.

Comparative Study on Schizontocidal Activity of Recrystallized or Crude Daphnetin Against Malaria Parasites

Funds:  国家自然科学基金(39970669)%Artemisinin Science Foundation
  • To compare the schizontocidal activity of recrystallized or crude daphnetin against malaria parasites in vivo. Methods Schizontocidal activity of recrystallized or crude daphnetin at various dosages was assessed in mice infected with Plasmodium berghei ANKA using a "4-day suppress assay". Results The comparison of the reduction rate of parasitemia caused by either recrystallized or crude dephnetin showed that ED50 of crude daphnetin was 18.36 mg/kg, with 95% confidence limit of 5.96-56.54 mg/kg while ED50 of recrystallized daphnetin was 11.46 mg/kg, with 95% confidence limit of 8.63-15.22 mg/kg. Conclution The results indicate that the efficacy of recrystallized daphnetin is 37.6% higher than that of crude daphnetin.
  • 加载中
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(718) PDF downloads(3) Cited by()

Proportional views
Related

Comparative Study on Schizontocidal Activity of Recrystallized or Crude Daphnetin Against Malaria Parasites

Funds:  国家自然科学基金(39970669)%Artemisinin Science Foundation

Abstract: To compare the schizontocidal activity of recrystallized or crude daphnetin against malaria parasites in vivo. Methods Schizontocidal activity of recrystallized or crude daphnetin at various dosages was assessed in mice infected with Plasmodium berghei ANKA using a "4-day suppress assay". Results The comparison of the reduction rate of parasitemia caused by either recrystallized or crude dephnetin showed that ED50 of crude daphnetin was 18.36 mg/kg, with 95% confidence limit of 5.96-56.54 mg/kg while ED50 of recrystallized daphnetin was 11.46 mg/kg, with 95% confidence limit of 8.63-15.22 mg/kg. Conclution The results indicate that the efficacy of recrystallized daphnetin is 37.6% higher than that of crude daphnetin.

QIN-MEI WANG, YI-CHANG NI, Jian Guo, JIA-TONG WU, YING-JUN QIAN. Comparative Study on Schizontocidal Activity of Recrystallized or Crude Daphnetin Against Malaria Parasites[J]. Biomedical and Environmental Sciences, 2004, 17(4): 397-401.
Citation: QIN-MEI WANG, YI-CHANG NI, Jian Guo, JIA-TONG WU, YING-JUN QIAN. Comparative Study on Schizontocidal Activity of Recrystallized or Crude Daphnetin Against Malaria Parasites[J]. Biomedical and Environmental Sciences, 2004, 17(4): 397-401.

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return