Volume 18 Issue 5
Oct.  2005
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SU-MIN LI, XIAO-MING WANG, JIN QIU, QIN SI, HENG-YI GUO, REN-YU SUN, QI-XIA WU. Inhibitory Effects of Alpha-zearalenol on Angiotensin II-Induced Integrin β3 mRNA via Suppression of Nuclear Factor-κB[J]. Biomedical and Environmental Sciences, 2005, 18(5): 314-320.
Citation: SU-MIN LI, XIAO-MING WANG, JIN QIU, QIN SI, HENG-YI GUO, REN-YU SUN, QI-XIA WU. Inhibitory Effects of Alpha-zearalenol on Angiotensin II-Induced Integrin β3 mRNA via Suppression of Nuclear Factor-κB[J]. Biomedical and Environmental Sciences, 2005, 18(5): 314-320.

Inhibitory Effects of Alpha-zearalenol on Angiotensin II-Induced Integrin β3 mRNA via Suppression of Nuclear Factor-κB

Funds:  国家自然科学基金(39730020, 39730220)
  • Objective To investigate the effect of ?-zearalenol on angiotensin II-induced β3 integrin mRNA expression in human umbilical vein endothelial cells (HUVECs). Methods The mRNA level in integrin β3 was determined by reverse transcription-polymerase chain reaction. Endothelial NF-(B activity was determined by the luciferase activity assay of plasmid NF-(B-LUC. Results The angiotensin II- induced β3 integrin mRNA expression was inhibited by α-zearalenol and 17β-estradiol (10 nmol/L -1 (mol/L), but not influenced by ICI 182, 780, a pure competitive antagonist for estrogen receptor or a nitric oxide inhibitor Nω-Nitro-L-arginine methyl ester hydrochloride. Alpha-zearalenol and 17β-estradiol suppressed the angiotensin II-induced activation of NF-κB in endothelial cells. Conclusion Alpha-zearalenol inhibits angiotensin II-induced integrin β3 mRNA expression by suppressing NF-κB activation in endothelial cells.
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通讯作者: 陈斌, bchen63@163.com
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Inhibitory Effects of Alpha-zearalenol on Angiotensin II-Induced Integrin β3 mRNA via Suppression of Nuclear Factor-κB

Funds:  国家自然科学基金(39730020, 39730220)

Abstract: Objective To investigate the effect of ?-zearalenol on angiotensin II-induced β3 integrin mRNA expression in human umbilical vein endothelial cells (HUVECs). Methods The mRNA level in integrin β3 was determined by reverse transcription-polymerase chain reaction. Endothelial NF-(B activity was determined by the luciferase activity assay of plasmid NF-(B-LUC. Results The angiotensin II- induced β3 integrin mRNA expression was inhibited by α-zearalenol and 17β-estradiol (10 nmol/L -1 (mol/L), but not influenced by ICI 182, 780, a pure competitive antagonist for estrogen receptor or a nitric oxide inhibitor Nω-Nitro-L-arginine methyl ester hydrochloride. Alpha-zearalenol and 17β-estradiol suppressed the angiotensin II-induced activation of NF-κB in endothelial cells. Conclusion Alpha-zearalenol inhibits angiotensin II-induced integrin β3 mRNA expression by suppressing NF-κB activation in endothelial cells.

SU-MIN LI, XIAO-MING WANG, JIN QIU, QIN SI, HENG-YI GUO, REN-YU SUN, QI-XIA WU. Inhibitory Effects of Alpha-zearalenol on Angiotensin II-Induced Integrin β3 mRNA via Suppression of Nuclear Factor-κB[J]. Biomedical and Environmental Sciences, 2005, 18(5): 314-320.
Citation: SU-MIN LI, XIAO-MING WANG, JIN QIU, QIN SI, HENG-YI GUO, REN-YU SUN, QI-XIA WU. Inhibitory Effects of Alpha-zearalenol on Angiotensin II-Induced Integrin β3 mRNA via Suppression of Nuclear Factor-κB[J]. Biomedical and Environmental Sciences, 2005, 18(5): 314-320.

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