ENPP1/PC-1 Gene K121Q Polymorphism Is Associated with Obesity in European Adult Populations: Evidence from A Meta-Analysis Involving 24 324 Subjects

WANG RuoQi,  ZHOU DongHao,  XI Bo,  GE XiuShan,  ZHU Ping,  WANG Bo,  ZHOU MingAi,  HUANG YuBei,  LIU JunTing,  YU Yang,  WANG ChunYu

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文章导航 > Biomedical and Environmental Sciences  > 2011 >  24(2): 200-206
WANG RuoQi, ZHOU DongHao, XI Bo, GE XiuShan, ZHU Ping, WANG Bo, ZHOU MingAi, HUANG YuBei, LIU JunTing, YU Yang, WANG ChunYu. ENPP1/PC-1 Gene K121Q Polymorphism Is Associated with Obesity in European Adult Populations: Evidence from A Meta-Analysis Involving 24 324 Subjects[J]. Biomedical and Environmental Sciences, 2011, 24(2): 200-206. doi: 10.3967/0895-3988.2011.02.015
Citation: WANG RuoQi, ZHOU DongHao, XI Bo, GE XiuShan, ZHU Ping, WANG Bo, ZHOU MingAi, HUANG YuBei, LIU JunTing, YU Yang, WANG ChunYu. ENPP1/PC-1 Gene K121Q Polymorphism Is Associated with Obesity in European Adult Populations: Evidence from A Meta-Analysis Involving 24 324 Subjects[J]. Biomedical and Environmental Sciences, 2011, 24(2): 200-206. doi: 10.3967/0895-3988.2011.02.015
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doi: 10.3967/0895-3988.2011.02.015
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ENPP1/PC-1 Gene K121Q Polymorphism Is Associated with Obesity in European Adult Populations: Evidence from A Meta-Analysis Involving 24 324 Subjects

  • Department of Cardiology, Affiliated Hospital of Youjiang Medical College for Nationalities, Baise 533000,Guangxi, China

  • Department of Endocrinology, Linyi People's Hospital. Linyi 276002, Shandong, China

  • Department of Maternal and Child Health Care, School of Public Health, Shandong University, Jinan 250012, Shandong, China

  • Department of Genetics, Capital Institute of Pediatrics, Beijing 100020, China

  • Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510100, Guangdong, China

  • Publishing House, Chinese Academy of Medical Sciences, Beijing 100730, China

  • Department of Internal Medicine, Linyi Hospital of Traditional Chinese Medicine, Linyi 276002, Shandong, China

  • Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100083, China

  • Department of Epidemiology, Capital Institute of Pediatrics, Beijing 100020, China

  • Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA

  • Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA;The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA

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  • 刊出日期:  2011-04-20

ENPP1/PC-1 Gene K121Q Polymorphism Is Associated with Obesity in European Adult Populations: Evidence from A Meta-Analysis Involving 24 324 Subjects

doi: 10.3967/0895-3988.2011.02.015
  • 刊出日期: 2011-04-20

摘要: Objective Findings from the previous studies have suggested a relationship between ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP-1) or plasma cell membrane glycoprotein 1 (PC-1) gene single nucleotide polymorphism (K121Q, rs1044498) and genetic susceptibility to obesity. However, such relationship is not reproduced by some currently available studies. In this context, the present study is aimed to quantitatively analyze the association of K121Q variant with obesity in all published case-control studies in European adult populations. Methods Published literature from PubMed, EMBASE, and ISI web of science databases were retrieved. The studies evaluating the association of ENPP1/PC1 gene K121Q polymorphism with obesity were included, in which sufficient data were presented to calculate the odds ratio (OR) with 95% confidence intervals (Cls). Results Ten case-control studies meeting the inclusion criteria identified a total of 24,324 subjects including 11,372 obese and 12,952 control subjects. The meta-analysis results showed a statistically significant association of K121Q with obesity [OR (95%Cl): 1.25 (1.04-1.52) P=0.021] under a recessive model of inheritance (QQ vs. KK+KQ) without heterogeneity or publication bias. Conclusions The results from the present study have indicated that ENPP1/PC1 Q121 variant may increase the risk of obesity and that more well-designed studies based on a larger population will be required to further evaluate the role of ENPP1/PC1 gene K121Q, polymorphism in obesity and other related metabolic syndromes.

English Abstract

WANG RuoQi, ZHOU DongHao, XI Bo, GE XiuShan, ZHU Ping, WANG Bo, ZHOU MingAi, HUANG YuBei, LIU JunTing, YU Yang, WANG ChunYu. ENPP1/PC-1 Gene K121Q Polymorphism Is Associated with Obesity in European Adult Populations: Evidence from A Meta-Analysis Involving 24 324 Subjects[J]. Biomedical and Environmental Sciences, 2011, 24(2): 200-206. doi: 10.3967/0895-3988.2011.02.015
Citation: WANG RuoQi, ZHOU DongHao, XI Bo, GE XiuShan, ZHU Ping, WANG Bo, ZHOU MingAi, HUANG YuBei, LIU JunTing, YU Yang, WANG ChunYu. ENPP1/PC-1 Gene K121Q Polymorphism Is Associated with Obesity in European Adult Populations: Evidence from A Meta-Analysis Involving 24 324 Subjects[J]. Biomedical and Environmental Sciences, 2011, 24(2): 200-206. doi: 10.3967/0895-3988.2011.02.015
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