Arjun L KHANDARE; Uday KUMAR; Priyanka SHANKAR; Shanker RAO

doi:10.3967/0895-3988.2013.04.010

Copper Ameliorates Fluoride Toxicity in Fluoride and Molybdenum Fed Rabbits

Arjun L KHANDARE, Uday KUMAR, Priyanka SHANKAR, Shanker RAO

文章导航 > Biomedical and Environmental Sciences > 2013 > 26(4): 311-313

Arjun L KHANDARE, Uday KUMAR, Priyanka SHANKAR, Shanker RAO. Copper Ameliorates Fluoride Toxicity in Fluoride and Molybdenum Fed Rabbits[J]. Biomedical and Environmental Sciences, 2013, 26(4): 311-313. doi: 10.3967/0895-3988.2013.04.010

Citation:

Arjun L KHANDARE, Uday KUMAR, Priyanka SHANKAR, Shanker RAO. Copper Ameliorates Fluoride Toxicity in Fluoride and Molybdenum Fed Rabbits[J]. Biomedical and Environmental Sciences, 2013, 26(4): 311-313. doi: 10.3967/0895-3988.2013.04.010

doi: 10.3967/0895-3988.2013.04.010

Copper Ameliorates Fluoride Toxicity in Fluoride and Molybdenum Fed Rabbits

Food and Drug Toxicology Centre, National Institute of Nutrition, Indian Council of Medical Research, POJama-I-Osmania, Hyderabad-500007, Andhra Pradesh, India
Department of Pathology, National Institute of Nutrition,Hyderabad, India.

摘要: Hydrofluorosis is a major public health problem in India, which is aggravated by presence or absence of some minerals in water or food.Fluoride by itself or in combination with other elements like molybdenum (Mo) in diet or water changes excretion/retention of bone minerals.Sorghum and pearl millet grown and consumed in fluorosis endemic areas contained significantly higher amounts of Mo than that grown in non-fluorotic areas in India[1].Epidemiological studies show that the prevalence of genu valgum in areas with fluorosis is significantly higher in subjects, whose staple is sorghum (4%) as compared to those whose staple is rice (1%)[2].High molybdenum ingestion leads to secondary copper deficiency due to increased loss of copper through urine[3].Copper plays an important role in collagen synthesis.Biographical note of the first author: Dr.Arjun L.Khandare, born in 1959, M.Sc.Ph.D.in Biochemistry, majoring in the group leader of food and drug toxicology research center since 2005, working on fluoride and fluorosis since 2000.
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- collagen synthesis /
- public health /
- genu valgum

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Copper Ameliorates Fluoride Toxicity in Fluoride and Molybdenum Fed Rabbits

doi: 10.3967/0895-3988.2013.04.010

刊出日期: 2013-04-20

关键词:

collagen synthesis /

public health /

genu valgum

摘要: Hydrofluorosis is a major public health problem in India, which is aggravated by presence or absence of some minerals in water or food.Fluoride by itself or in combination with other elements like molybdenum (Mo) in diet or water changes excretion/retention of bone minerals.Sorghum and pearl millet grown and consumed in fluorosis endemic areas contained significantly higher amounts of Mo than that grown in non-fluorotic areas in India[1].Epidemiological studies show that the prevalence of genu valgum in areas with fluorosis is significantly higher in subjects, whose staple is sorghum (4%) as compared to those whose staple is rice (1%)[2].High molybdenum ingestion leads to secondary copper deficiency due to increased loss of copper through urine[3].Copper plays an important role in collagen synthesis.Biographical note of the first author: Dr.Arjun L.Khandare, born in 1959, M.Sc.Ph.D.in Biochemistry, majoring in the group leader of food and drug toxicology research center since 2005, working on fluoride and fluorosis since 2000.