GAO Liang; WANG Han Ning; ZHANG Ling; PENG Fang Yuan; JIA Yue; WEI Wei; JIA Li Hong

doi:10.3967/bes2016.092

Effect of Perinatal Bisphenol A Exposure on Serum Lipids and Lipid Enzymes in Offspring Rats of Different Sex

GAO Liang, WANG Han Ning, ZHANG Ling, PENG Fang Yuan, JIA Yue, WEI Wei, JIA Li Hong

文章导航 > Biomedical and Environmental Sciences > 2016 > 29(9): 686-689

GAO Liang, WANG Han Ning, ZHANG Ling, PENG Fang Yuan, JIA Yue, WEI Wei, JIA Li Hong. Effect of Perinatal Bisphenol A Exposure on Serum Lipids and Lipid Enzymes in Offspring Rats of Different Sex[J]. Biomedical and Environmental Sciences, 2016, 29(9): 686-689. doi: 10.3967/bes2016.092

Citation:

GAO Liang, WANG Han Ning, ZHANG Ling, PENG Fang Yuan, JIA Yue, WEI Wei, JIA Li Hong. Effect of Perinatal Bisphenol A Exposure on Serum Lipids and Lipid Enzymes in Offspring Rats of Different Sex[J]. Biomedical and Environmental Sciences, 2016, 29(9): 686-689. doi: 10.3967/bes2016.092

doi: 10.3967/bes2016.092

基金项目: This research was supported by Liaoning Nature Science Foundation of China(project number 2015020466)%by the National Natural Science Foundation of China(project number 81072311)

Effect of Perinatal Bisphenol A Exposure on Serum Lipids and Lipid Enzymes in Offspring Rats of Different Sex

Department of Child and Adolescent Health, School of Public Health, China Medical University, Shenyang 110122,Liaoning, China
Department of Sports Medicine and Joint Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning, China

Funds: This research was supported by Liaoning Nature Science Foundation of China(project number 2015020466)%by the National Natural Science Foundation of China(project number 81072311)

摘要: Rats were exposed to 1 or 10 μg/mL bisphenol A (BPA) in water during pregnancy and lactation.Offspring rats were given normal water and a standard diet from weaning to postnatal day (PND) 50.Perinatal exposure to BPA resulted in significantly increased body weight,visceral adipose tissue,abnormal serum lipids,and lower adiponectin (ADP) levels in both female and male offspring rats.Liver adipose triglyceride lipase (Atgl)mRNA levels and ADP protein in visceral adipose tissue were significantly decreased in BPA-exposed offspring rats.In both female or male offspring rats,obesity and dyslipidemia induced by perinatal exposure to BPA were associated with down regulation of Atgl mRNA in liver and ADP protein in visceral adipose tissue.

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Effect of Perinatal Bisphenol A Exposure on Serum Lipids and Lipid Enzymes in Offspring Rats of Different Sex

doi: 10.3967/bes2016.092

基金项目: This research was supported by Liaoning Nature Science Foundation of China(project number 2015020466)%by the National Natural Science Foundation of China(project number 81072311)

刊出日期: 2016-09-20

摘要: Rats were exposed to 1 or 10 μg/mL bisphenol A (BPA) in water during pregnancy and lactation.Offspring rats were given normal water and a standard diet from weaning to postnatal day (PND) 50.Perinatal exposure to BPA resulted in significantly increased body weight,visceral adipose tissue,abnormal serum lipids,and lower adiponectin (ADP) levels in both female and male offspring rats.Liver adipose triglyceride lipase (Atgl)mRNA levels and ADP protein in visceral adipose tissue were significantly decreased in BPA-exposed offspring rats.In both female or male offspring rats,obesity and dyslipidemia induced by perinatal exposure to BPA were associated with down regulation of Atgl mRNA in liver and ADP protein in visceral adipose tissue.

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Citation:

GAO Liang, WANG Han Ning, ZHANG Ling, PENG Fang Yuan, JIA Yue, WEI Wei, JIA Li Hong. Effect of Perinatal Bisphenol A Exposure on Serum Lipids and Lipid Enzymes in Offspring Rats of Different Sex[J]. Biomedical and Environmental Sciences, 2016, 29(9): 686-689. doi: 10.3967/bes2016.092

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doi: 10.3967/bes2016.092

Effect of Perinatal Bisphenol A Exposure on Serum Lipids and Lipid Enzymes in Offspring Rats of Different Sex

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Effect of Perinatal Bisphenol A Exposure on Serum Lipids and Lipid Enzymes in Offspring Rats of Different Sex

doi: 10.3967/bes2016.092

English Abstract

Effect of Perinatal Bisphenol A Exposure on Serum Lipids and Lipid Enzymes in Offspring Rats of Different Sex

Department of Child and Adolescent Health, School of Public Health, China Medical University, Shenyang 110122,Liaoning, China

Department of Sports Medicine and Joint Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning, China

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doi: 10.3967/bes2016.092

Effect of Perinatal Bisphenol A Exposure on Serum Lipids and Lipid Enzymes in Offspring Rats of Different Sex

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Effect of Perinatal Bisphenol A Exposure on Serum Lipids and Lipid Enzymes in Offspring Rats of Different Sex

doi: 10.3967/bes2016.092

English Abstract

Effect of Perinatal Bisphenol A Exposure on Serum Lipids and Lipid Enzymes in Offspring Rats of Different Sex

Department of Child and Adolescent Health, School of Public Health, China Medical University, Shenyang 110122,Liaoning, China Department of Sports Medicine and Joint Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning, China

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目录

Department of Child and Adolescent Health, School of Public Health, China Medical University, Shenyang 110122,Liaoning, China

Department of Sports Medicine and Joint Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning, China