Mohamed A Dkhil; Mona F Khalil; Amira A Bauomy; Marwa SM Diab; Saleh Al-Qura

doi:10.3967/bes2016.104

Efficacy of Gold Nanoparticles against Nephrotoxicity Induced by Schistosoma mansoni Infection in Mice

Mohamed A Dkhil, Mona F Khalil, Amira A Bauomy, Marwa SM Diab, Saleh Al-Qura

文章导航 > Biomedical and Environmental Sciences > 2016 > 29(11): 773-781

Mohamed A Dkhil, Mona F Khalil, Amira A Bauomy, Marwa SM Diab, Saleh Al-Qura. Efficacy of Gold Nanoparticles against Nephrotoxicity Induced by Schistosoma mansoni Infection in Mice[J]. Biomedical and Environmental Sciences, 2016, 29(11): 773-781. doi: 10.3967/bes2016.104

Citation:

Mohamed A Dkhil, Mona F Khalil, Amira A Bauomy, Marwa SM Diab, Saleh Al-Qura. Efficacy of Gold Nanoparticles against Nephrotoxicity Induced by Schistosoma mansoni Infection in Mice[J]. Biomedical and Environmental Sciences, 2016, 29(11): 773-781. doi: 10.3967/bes2016.104

doi: 10.3967/bes2016.104

Efficacy of Gold Nanoparticles against Nephrotoxicity Induced by Schistosoma mansoni Infection in Mice

Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo 11795, Egypt
Molecular Drug Evaluation Department, National 0rganization for Drug Control&Research N0DCAR, Giza 12553, Egypt

摘要: Objective In this study, the ameliorative effects of gold nanoparticles (gold NP) on the renal tissue damage in Schistosoma mansoni (S. mansoni)-infected mice was investigated.
Methods High-resolution transmission electron microscopy was used for the characterization of NP. The gold NP at concentrations of 250, 500, and 1000 μg/kg body weight were inoculated into S. mansoni-infected mice.
Results The parasite caused alterations in the histological architecture. Furthermore, it induced a significant reduction in the renal glutathione levels; however, the levels of nitric oxide and malondialdehyde were significantly elevated. The parasite also managed to downregulate KIM-1, NGAL, MCP-1, and TGF-βmRNA expression in infected animals. Notably, gold NP treatment in mice reduced the extent of histological impairment and renal oxidative damage. Gold NP were able to regulate gene expression impaired by S. Mansoni infection.
Conclusion The curative effect of gold NP against renal toxicity in S. mansoni-infected mice is associated with their role as free radical scavengers.
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Abstract: Objective In this study, the ameliorative effects of gold nanoparticles (gold NP) on the renal tissue damage in Schistosoma mansoni (S. mansoni)-infected mice was investigated.
Methods High-resolution transmission electron microscopy was used for the characterization of NP. The gold NP at concentrations of 250, 500, and 1000 μg/kg body weight were inoculated into S. mansoni-infected mice.
Results The parasite caused alterations in the histological architecture. Furthermore, it induced a significant reduction in the renal glutathione levels; however, the levels of nitric oxide and malondialdehyde were significantly elevated. The parasite also managed to downregulate KIM-1, NGAL, MCP-1, and TGF-βmRNA expression in infected animals. Notably, gold NP treatment in mice reduced the extent of histological impairment and renal oxidative damage. Gold NP were able to regulate gene expression impaired by S. Mansoni infection.
Conclusion The curative effect of gold NP against renal toxicity in S. mansoni-infected mice is associated with their role as free radical scavengers.
- Gold nanoparticles /
- Schistosomiasis /
- Renal damage /
- Gene expression /
- Histopathology /
- Oxidative stress

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Efficacy of Gold Nanoparticles against Nephrotoxicity Induced by Schistosoma mansoni Infection in Mice

doi: 10.3967/bes2016.104

刊出日期: 2016-11-20

关键词:

摘要: Objective In this study, the ameliorative effects of gold nanoparticles (gold NP) on the renal tissue damage in Schistosoma mansoni (S. mansoni)-infected mice was investigated.
Methods High-resolution transmission electron microscopy was used for the characterization of NP. The gold NP at concentrations of 250, 500, and 1000 μg/kg body weight were inoculated into S. mansoni-infected mice.
Results The parasite caused alterations in the histological architecture. Furthermore, it induced a significant reduction in the renal glutathione levels; however, the levels of nitric oxide and malondialdehyde were significantly elevated. The parasite also managed to downregulate KIM-1, NGAL, MCP-1, and TGF-βmRNA expression in infected animals. Notably, gold NP treatment in mice reduced the extent of histological impairment and renal oxidative damage. Gold NP were able to regulate gene expression impaired by S. Mansoni infection.
Conclusion The curative effect of gold NP against renal toxicity in S. mansoni-infected mice is associated with their role as free radical scavengers.

English Abstract

Efficacy of Gold Nanoparticles against Nephrotoxicity Induced by Schistosoma mansoni Infection in Mice

Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia

Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo 11795, Egypt

Molecular Drug Evaluation Department, National 0rganization for Drug Control&Research N0DCAR, Giza 12553, Egypt

Publish Date: 2016-11-20

Keywords:

Abstract: Objective In this study, the ameliorative effects of gold nanoparticles (gold NP) on the renal tissue damage in Schistosoma mansoni (S. mansoni)-infected mice was investigated.
Methods High-resolution transmission electron microscopy was used for the characterization of NP. The gold NP at concentrations of 250, 500, and 1000 μg/kg body weight were inoculated into S. mansoni-infected mice.
Results The parasite caused alterations in the histological architecture. Furthermore, it induced a significant reduction in the renal glutathione levels; however, the levels of nitric oxide and malondialdehyde were significantly elevated. The parasite also managed to downregulate KIM-1, NGAL, MCP-1, and TGF-βmRNA expression in infected animals. Notably, gold NP treatment in mice reduced the extent of histological impairment and renal oxidative damage. Gold NP were able to regulate gene expression impaired by S. Mansoni infection.
Conclusion The curative effect of gold NP against renal toxicity in S. mansoni-infected mice is associated with their role as free radical scavengers.

Citation:

Mohamed A Dkhil, Mona F Khalil, Amira A Bauomy, Marwa SM Diab, Saleh Al-Qura. Efficacy of Gold Nanoparticles against Nephrotoxicity Induced by Schistosoma mansoni Infection in Mice[J]. Biomedical and Environmental Sciences, 2016, 29(11): 773-781. doi: 10.3967/bes2016.104

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doi: 10.3967/bes2016.104

Efficacy of Gold Nanoparticles against Nephrotoxicity Induced by Schistosoma mansoni Infection in Mice

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Efficacy of Gold Nanoparticles against Nephrotoxicity Induced by Schistosoma mansoni Infection in Mice

doi: 10.3967/bes2016.104

English Abstract

Efficacy of Gold Nanoparticles against Nephrotoxicity Induced by Schistosoma mansoni Infection in Mice

Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo 11795, Egypt Molecular Drug Evaluation Department, National 0rganization for Drug Control&Research N0DCAR, Giza 12553, Egypt

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