Mohamed A Dkhil; Mona F Khalil; Amira A Bauomy; Marwa SM Diab; Saleh Al-Qura

doi:10.3967/bes2016.104

Efficacy of Gold Nanoparticles against Nephrotoxicity Induced by Schistosoma mansoni Infection in Mice

Mohamed A Dkhil, Mona F Khalil, Amira A Bauomy, Marwa SM Diab, Saleh Al-Qura

文章导航 > Biomedical and Environmental Sciences > 2016 > 29(11): 773-781

Mohamed A Dkhil, Mona F Khalil, Amira A Bauomy, Marwa SM Diab, Saleh Al-Qura. Efficacy of Gold Nanoparticles against Nephrotoxicity Induced by Schistosoma mansoni Infection in Mice[J]. Biomedical and Environmental Sciences, 2016, 29(11): 773-781. doi: 10.3967/bes2016.104

Citation:

Mohamed A Dkhil, Mona F Khalil, Amira A Bauomy, Marwa SM Diab, Saleh Al-Qura. Efficacy of Gold Nanoparticles against Nephrotoxicity Induced by Schistosoma mansoni Infection in Mice[J]. Biomedical and Environmental Sciences, 2016, 29(11): 773-781. doi: 10.3967/bes2016.104

doi: 10.3967/bes2016.104

Efficacy of Gold Nanoparticles against Nephrotoxicity Induced by Schistosoma mansoni Infection in Mice

Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo 11795, Egypt
Molecular Drug Evaluation Department, National 0rganization for Drug Control&Research N0DCAR, Giza 12553, Egypt

摘要: Objective In this study, the ameliorative effects of gold nanoparticles (gold NP) on the renal tissue damage in Schistosoma mansoni (S. mansoni)-infected mice was investigated.
Methods High-resolution transmission electron microscopy was used for the characterization of NP. The gold NP at concentrations of 250, 500, and 1000 μg/kg body weight were inoculated into S. mansoni-infected mice.
Results The parasite caused alterations in the histological architecture. Furthermore, it induced a significant reduction in the renal glutathione levels; however, the levels of nitric oxide and malondialdehyde were significantly elevated. The parasite also managed to downregulate KIM-1, NGAL, MCP-1, and TGF-βmRNA expression in infected animals. Notably, gold NP treatment in mice reduced the extent of histological impairment and renal oxidative damage. Gold NP were able to regulate gene expression impaired by S. Mansoni infection.
Conclusion The curative effect of gold NP against renal toxicity in S. mansoni-infected mice is associated with their role as free radical scavengers.
- /
- /
- /
- /
- /
Abstract: Objective In this study, the ameliorative effects of gold nanoparticles (gold NP) on the renal tissue damage in Schistosoma mansoni (S. mansoni)-infected mice was investigated.
Methods High-resolution transmission electron microscopy was used for the characterization of NP. The gold NP at concentrations of 250, 500, and 1000 μg/kg body weight were inoculated into S. mansoni-infected mice.
Results The parasite caused alterations in the histological architecture. Furthermore, it induced a significant reduction in the renal glutathione levels; however, the levels of nitric oxide and malondialdehyde were significantly elevated. The parasite also managed to downregulate KIM-1, NGAL, MCP-1, and TGF-βmRNA expression in infected animals. Notably, gold NP treatment in mice reduced the extent of histological impairment and renal oxidative damage. Gold NP were able to regulate gene expression impaired by S. Mansoni infection.
Conclusion The curative effect of gold NP against renal toxicity in S. mansoni-infected mice is associated with their role as free radical scavengers.
- Gold nanoparticles /
- Schistosomiasis /
- Renal damage /
- Gene expression /
- Histopathology /
- Oxidative stress

[1]	Jinyu Fang, Huaicun Liu, Yanfei Zhang, Quancheng Cheng, Ziyuan Wang, Xuan Fang, Huiru Ding, Weiguang Zhang, Chunhua Chen. Nogo-A Protein Mediates Oxidative Stress and Synaptic Damage Induced by High-altitude Hypoxia in the Rat Hippocampus . Biomedical and Environmental Sciences, 2024, 37(): 1-16. doi: 10.3967/bes2024.112
[2]	YANG Hui, ZUO Xue Zhi, TIAN Chong, HE Dong Liang, YI Wei Jie, CHEN Zhuo, ZHANG Pi Wei, DING Shi Bin, YING Chen Jiang. Green Tea Polyphenols Attenuate High-Fat Diet-Induced Renal Oxidative Stress through SIRT3-Dependent Deacetylation . Biomedical and Environmental Sciences, 2015, 28(6): 455-459. doi: 10.3967/bes2015.064
[3]	ZHANG Wen, WANG Chuan, HUANG Cheng Yu, YU Qian, LIU Heng Chuan, ZHANG Chap Wu, PEI Xiao Fang. Construction and Secretory Expression of β-Galactosidase Gene from Lactobacillus Bulgaricus in Lactococcus Lactis . Biomedical and Environmental Sciences, 2012, 25(2): 203-209. doi: 10.3967/0895-3988.2012.02.012
[4]	CHARGUI Issam, GRISSA Intissar, BENSASSI Fatma, HRIRA Mohamed Yahia, HAOUEM Samir, HAOUAS Zohra, BENCHEIKH Hassen. Oxidative Stress, Biochemical and Histopathological Alterations in the Liver and Kidney of Female Rats Exposed to Low Doses of Deltamethrin (DM): A Molecular Assessment . Biomedical and Environmental Sciences, 2012, 25(6): 672-683. doi: 10.3967/0895-3988.2012.06.009
[5]	YANG HaiBo, XU ZhaoFa, LIU Wei, DENG Yu, XU Bin. The Protective Role of Procyanidins and Lycopene Against Mercuric Chloride Renal Damage in Rats . Biomedical and Environmental Sciences, 2011, 24(5): 550-559. doi: 10.3967/0895-3988.2011.05.015
[6]	YOU-GEN ZHU, SHU-MEI ZHANG, JI-YUE WANG, WEI-QIANG XIAO, XIN-YU WANG, JUN-FU ZHOU. Overweight and Obesity-Induced Oxidative Stress in Children . Biomedical and Environmental Sciences, 2006, 19(5): 353-359.
[7]	RI-AN YU, TAO XIA, AI-GUO WANG, XUE-MIN CHEN. Effects of Selenium and Zinc on Renal Oxidative Stress and Apoptosis Induced by Fluoride in Rats . Biomedical and Environmental Sciences, 2006, 19(6): 439-444.
[8]	JIAN-GUO LOU, JIE DONG, YI-CHUN ZHENG, SHU-MEI ZHANG, WEI-QIANG XIAO, JUN-FU ZHOU. Increased Oxidative Stress and Damage in Patients With Chronic Bacterial Prostatitis . Biomedical and Environmental Sciences, 2006, 19(6): 481-486.
[9]	JIN-PING CHENG, WEN-HUA WANG, LI-YA QU, JIN-PING JIA, MIN Zheng, XIU-LING JI, TAO Yuan. Rice From Mercury Contaminated Areas in Guizhou Province Induces c-jun Expression in Rat Brain . Biomedical and Environmental Sciences, 2005, 18(2): 96-102.
[10]	JUN-FU ZHOU, XIN-YU WANG, XUE-JUN SHANGGUAN, ZU-MING GAO, SHU-MEI ZHANG, WEI-QIANG XIAO, CHANG-GUI CHEN. Increased Oxidative Stress in Women With Pregnancy-induced Hypertension . Biomedical and Environmental Sciences, 2005, 18(6): 419-426.
[11]	YOU-GEN ZHU, JUN-FU ZHOU, WEI-YING SHAN, PEI-SU ZHOU, GUI-ZHONG TONG. Potential Oxidative Stress in the Bodies of Electric Arc Welding Operators:Effect of Photochemical Smog . Biomedical and Environmental Sciences, 2004, 17(4): 381-389.
[12]	JI-YUE WANG, YE-LING WANG, SHENG-LI ZHOU, JUN-FU ZHOU. May Chronic Childhood Constipation Cause Oxidative Stress and Potential Free Radical Damage to Children? . Biomedical and Environmental Sciences, 2004, 17(3): 266-272.
[13]	JUN-FU ZHOU, WEN ZHOU, SHU-MEI ZHANG, YAN-ER LUO, Huai-Hong Chen. Oxidative Stress and Free Radical Damage in Patients With Acute Dipterex Poisoning . Biomedical and Environmental Sciences, 2004, 17(2): 223-233.
[14]	YUE-XIN LIANG, Zhen Wang, DIAN-DONG LI, JIAN-MIN JIANG, RONG-GUANG SHAO. Effects of Aging and Advanced Glycation on Gene Expression in Cerebrum and Spleen of Mice . Biomedical and Environmental Sciences, 2003, 16(4): 323-332.
[15]	JUN-FU ZHOU, YE-HUA ZHOU, Liang Zhang, Huai-Hong Chen, DONG CAI. 3,4-Methylenedioxymethamphetamine (MDMA) Abuse Markedly Inhibits Acetylcholinesterase Activity and Induces Severe Oxidative Damage and Liperoxidative Damage . Biomedical and Environmental Sciences, 2003, 16(1): 53-61.
[16]	JUN-FU ZHOU, WEI-WEI CHEN, GUI-ZHONG TONG. Ozone Emitted During Copying Process -A Potential Cause of Pathological Oxidative Stress and Potential Oxidative Damage in the Bodies of Operators . Biomedical and Environmental Sciences, 2003, 16(2): 95-104.
[17]	ZHOU JUN-FU, CHEN Jia-xi, SHEN Han-chao, CAI DONG. Abnormal Reactions of Free Radicals and Oxidative Damages in the Bodies of Patients With Chronic Glomerulonephritis . Biomedical and Environmental Sciences, 2002, 15(3): 233-244.
[18]	XIE Bo, ZHOU JUN-FU, LU Qun, LI Chong-jian, CHEN PENG. Oxidative Stress in Patients With Acute Coxsackie Virus Myocarditis . Biomedical and Environmental Sciences, 2002, 15(1): 48-57.
[19]	ZHOU JUN-FU, CHEN PENG. Studies on the Oxidative Stress in Alcohol Abusers in China . Biomedical and Environmental Sciences, 2001, 14(3): 180-188.
[20]	ZHOU JUN-FU, CHEN PENG, YANG JIN-LU, ZHU YOU-GEN, PENG Cheng-hong, WU Yu-lian. Oxidative Stress before and after Operation in Patients with Chronic Cholecystitis Containing Gallstone . Biomedical and Environmental Sciences, 2000, 13(4): 254-262.

点击查看大图

计量

文章访问数: 1275
HTML全文浏览量: 423
PDF下载量: 72
被引次数: 0

Efficacy of Gold Nanoparticles against Nephrotoxicity Induced by Schistosoma mansoni Infection in Mice

doi: 10.3967/bes2016.104

刊出日期: 2016-11-20

关键词:

摘要: Objective In this study, the ameliorative effects of gold nanoparticles (gold NP) on the renal tissue damage in Schistosoma mansoni (S. mansoni)-infected mice was investigated.
Methods High-resolution transmission electron microscopy was used for the characterization of NP. The gold NP at concentrations of 250, 500, and 1000 μg/kg body weight were inoculated into S. mansoni-infected mice.
Results The parasite caused alterations in the histological architecture. Furthermore, it induced a significant reduction in the renal glutathione levels; however, the levels of nitric oxide and malondialdehyde were significantly elevated. The parasite also managed to downregulate KIM-1, NGAL, MCP-1, and TGF-βmRNA expression in infected animals. Notably, gold NP treatment in mice reduced the extent of histological impairment and renal oxidative damage. Gold NP were able to regulate gene expression impaired by S. Mansoni infection.
Conclusion The curative effect of gold NP against renal toxicity in S. mansoni-infected mice is associated with their role as free radical scavengers.

English Abstract

Efficacy of Gold Nanoparticles against Nephrotoxicity Induced by Schistosoma mansoni Infection in Mice

Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia

Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo 11795, Egypt

Molecular Drug Evaluation Department, National 0rganization for Drug Control&Research N0DCAR, Giza 12553, Egypt

Publish Date: 2016-11-20

Keywords:

Abstract: Objective In this study, the ameliorative effects of gold nanoparticles (gold NP) on the renal tissue damage in Schistosoma mansoni (S. mansoni)-infected mice was investigated.
Methods High-resolution transmission electron microscopy was used for the characterization of NP. The gold NP at concentrations of 250, 500, and 1000 μg/kg body weight were inoculated into S. mansoni-infected mice.
Results The parasite caused alterations in the histological architecture. Furthermore, it induced a significant reduction in the renal glutathione levels; however, the levels of nitric oxide and malondialdehyde were significantly elevated. The parasite also managed to downregulate KIM-1, NGAL, MCP-1, and TGF-βmRNA expression in infected animals. Notably, gold NP treatment in mice reduced the extent of histological impairment and renal oxidative damage. Gold NP were able to regulate gene expression impaired by S. Mansoni infection.
Conclusion The curative effect of gold NP against renal toxicity in S. mansoni-infected mice is associated with their role as free radical scavengers.

Citation:

Mohamed A Dkhil, Mona F Khalil, Amira A Bauomy, Marwa SM Diab, Saleh Al-Qura. Efficacy of Gold Nanoparticles against Nephrotoxicity Induced by Schistosoma mansoni Infection in Mice[J]. Biomedical and Environmental Sciences, 2016, 29(11): 773-781. doi: 10.3967/bes2016.104

全文HTML

下载: 全尺寸图片幻灯片

返回文章

用微信扫码二维码

分享至好友和朋友圈

Biomedical and Environmental Sciences ISSN 0895-3988 CN 11-2816 / Q

Publish Under the Auspices of Chinese Center for Disease Control and Prevention

Distributed by Chinese Center for Disease Control and Prevention

Quick Links

Supported by Beijing Renhe Information Technology Co. Ltd E-mail: info@rhhz.net

doi: 10.3967/bes2016.104

Efficacy of Gold Nanoparticles against Nephrotoxicity Induced by Schistosoma mansoni Infection in Mice

计量

出版历程

Efficacy of Gold Nanoparticles against Nephrotoxicity Induced by Schistosoma mansoni Infection in Mice

doi: 10.3967/bes2016.104

English Abstract

Efficacy of Gold Nanoparticles against Nephrotoxicity Induced by Schistosoma mansoni Infection in Mice

Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo 11795, Egypt Molecular Drug Evaluation Department, National 0rganization for Drug Control&Research N0DCAR, Giza 12553, Egypt

全文HTML

目录