Volume 24 Issue 3
Jun.  2011
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ZHANG Bo, WANG Ping, ZHOU Quan, CHEN ChaoGang, ZHUO ShuYu, YE YanBin, HE QiQiang, CHEN YuMing, SU YiXiang. The Relationships between Erythrocyte Membrane n-6 to n-3 Polyunsaturated Fatty Acids Ratio and Blood Lipids and C-reactive Protein in Chinese Adults: An Observational Study[J]. Biomedical and Environmental Sciences, 2011, 24(3): 234-242. doi: 10.3967/0895-3988.2011.03.005
Citation: ZHANG Bo, WANG Ping, ZHOU Quan, CHEN ChaoGang, ZHUO ShuYu, YE YanBin, HE QiQiang, CHEN YuMing, SU YiXiang. The Relationships between Erythrocyte Membrane n-6 to n-3 Polyunsaturated Fatty Acids Ratio and Blood Lipids and C-reactive Protein in Chinese Adults: An Observational Study[J]. Biomedical and Environmental Sciences, 2011, 24(3): 234-242. doi: 10.3967/0895-3988.2011.03.005

The Relationships between Erythrocyte Membrane n-6 to n-3 Polyunsaturated Fatty Acids Ratio and Blood Lipids and C-reactive Protein in Chinese Adults: An Observational Study

doi: 10.3967/0895-3988.2011.03.005
Funds:  the National Natural Science Foundation of China(30872102)%the Diet Nutrition Research & Communication Grant of Danone Institute China(DIC2008-12)
  • Objective To investigate the relationships between erythrocyte membrane n-6:n-3 PUFAs ratio and blood lipids and high sensitivity C-reactive protein (hs-CRP).Methods The observational study consisted of a population-based cross-sectional study of 456 Chinese and a subsequent 1-year follow-up study of 171 subjects with the fasting plasma total cholesterol of 5.13-8.00 mmol/L.Results In the cross-sectional analysis, plasma low-density lipoprotein cholesterol (LDL-c) had a significant and negative association with the erythrocyte membrane n-6:n-3 PUFAs ratio (P for trend=0.019) after adjusting for sex, age and total PUFA percentage. In the follow-up study, 171 subjects were categorized into quartiles by the changes of n-6:n-3 ratio in erythrocyte membrane (△=month 12-month 0). In the top quartile whose ratios of n-6:n-3 increased by an average of 1.25 during the follow-up, the LDL-c-lowering extent was 3.3 times of that in the lowest quartile whose ratios of n-6:n-3 decreased by an average of 1.13 (-1.07 mmol/L v.s. -0.32 mmol/L). The hsCRP decreased by 0.11 mg/dL in the lowest quartile while increasing by 0.10 mg/dL in the top quartile (P for difference=0.052).Conclusion Our results suggested that the balance between n-6 and n-3 fatty acids may optimize the cardiovascular benefits from dietary PUFAs.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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The Relationships between Erythrocyte Membrane n-6 to n-3 Polyunsaturated Fatty Acids Ratio and Blood Lipids and C-reactive Protein in Chinese Adults: An Observational Study

doi: 10.3967/0895-3988.2011.03.005
Funds:  the National Natural Science Foundation of China(30872102)%the Diet Nutrition Research & Communication Grant of Danone Institute China(DIC2008-12)

Abstract: Objective To investigate the relationships between erythrocyte membrane n-6:n-3 PUFAs ratio and blood lipids and high sensitivity C-reactive protein (hs-CRP).Methods The observational study consisted of a population-based cross-sectional study of 456 Chinese and a subsequent 1-year follow-up study of 171 subjects with the fasting plasma total cholesterol of 5.13-8.00 mmol/L.Results In the cross-sectional analysis, plasma low-density lipoprotein cholesterol (LDL-c) had a significant and negative association with the erythrocyte membrane n-6:n-3 PUFAs ratio (P for trend=0.019) after adjusting for sex, age and total PUFA percentage. In the follow-up study, 171 subjects were categorized into quartiles by the changes of n-6:n-3 ratio in erythrocyte membrane (△=month 12-month 0). In the top quartile whose ratios of n-6:n-3 increased by an average of 1.25 during the follow-up, the LDL-c-lowering extent was 3.3 times of that in the lowest quartile whose ratios of n-6:n-3 decreased by an average of 1.13 (-1.07 mmol/L v.s. -0.32 mmol/L). The hsCRP decreased by 0.11 mg/dL in the lowest quartile while increasing by 0.10 mg/dL in the top quartile (P for difference=0.052).Conclusion Our results suggested that the balance between n-6 and n-3 fatty acids may optimize the cardiovascular benefits from dietary PUFAs.

ZHANG Bo, WANG Ping, ZHOU Quan, CHEN ChaoGang, ZHUO ShuYu, YE YanBin, HE QiQiang, CHEN YuMing, SU YiXiang. The Relationships between Erythrocyte Membrane n-6 to n-3 Polyunsaturated Fatty Acids Ratio and Blood Lipids and C-reactive Protein in Chinese Adults: An Observational Study[J]. Biomedical and Environmental Sciences, 2011, 24(3): 234-242. doi: 10.3967/0895-3988.2011.03.005
Citation: ZHANG Bo, WANG Ping, ZHOU Quan, CHEN ChaoGang, ZHUO ShuYu, YE YanBin, HE QiQiang, CHEN YuMing, SU YiXiang. The Relationships between Erythrocyte Membrane n-6 to n-3 Polyunsaturated Fatty Acids Ratio and Blood Lipids and C-reactive Protein in Chinese Adults: An Observational Study[J]. Biomedical and Environmental Sciences, 2011, 24(3): 234-242. doi: 10.3967/0895-3988.2011.03.005

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