Volume 24 Issue 6
Dec.  2011
Turn off MathJax
Article Contents

ZHANG Xiao Qiang, YIN Li Hong, TANG Meng, PU Yue Pu. ZnO, TiO2, SiO2, and Al2O3 Nanoparticles-induced Toxic Effects on Human Fetal Lung Fibroblasts[J]. Biomedical and Environmental Sciences, 2011, 24(6): 661-669. doi: 10.3967/0895-3988.2011.06.011
Citation: ZHANG Xiao Qiang, YIN Li Hong, TANG Meng, PU Yue Pu. ZnO, TiO2, SiO2, and Al2O3 Nanoparticles-induced Toxic Effects on Human Fetal Lung Fibroblasts[J]. Biomedical and Environmental Sciences, 2011, 24(6): 661-669. doi: 10.3967/0895-3988.2011.06.011

ZnO, TiO2, SiO2, and Al2O3 Nanoparticles-induced Toxic Effects on Human Fetal Lung Fibroblasts

doi: 10.3967/0895-3988.2011.06.011
Funds:  the National Basic Research Program of China(2011CB933404)%the Science Foundation of Jiangsu Key Laboratory for Biomaterials and Devices(2010LBMD05)%the Science Foundation of Southeast University(XJ2008335)
  • Objective This study aims to investigate and compare the toxic effects of four types of metal oxide (ZnO,TiO2,SiO2,and Al2O3) nanoparticles with similar primary size (~20 nm) on human fetal lung fibroblasts (HFL1) in vitro.Methods The HFL1 cells were exposed to the nanoparticles,and toxic effects were analyzed by using MTT assay,cellular morphology observation and Hoechst 33 258 staining.Results The results show that the four types of metal oxide nanoparticles lead to cellular mitochondrial dysfunction,morphological modifications and apoptosis at the concentration range of 0.25-1.50 mg/mL and the toxic effects are obviously displayed in dose-dependent manner.ZnO is the most toxic nanomaterials followed by TiO2,SiO2,and Al2O3 nanoparticles in a descending order.Conclusion The results highlight the differential cytotoxicity associated with exposure to ZnO,TiO2,SiO2,and Al2O3 nanoparticles,and suggest an extreme attention to safety utilization of these nanomaterials.
  • 加载中
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(1608) PDF downloads(93) Cited by()

Proportional views
Related

ZnO, TiO2, SiO2, and Al2O3 Nanoparticles-induced Toxic Effects on Human Fetal Lung Fibroblasts

doi: 10.3967/0895-3988.2011.06.011
Funds:  the National Basic Research Program of China(2011CB933404)%the Science Foundation of Jiangsu Key Laboratory for Biomaterials and Devices(2010LBMD05)%the Science Foundation of Southeast University(XJ2008335)

Abstract: Objective This study aims to investigate and compare the toxic effects of four types of metal oxide (ZnO,TiO2,SiO2,and Al2O3) nanoparticles with similar primary size (~20 nm) on human fetal lung fibroblasts (HFL1) in vitro.Methods The HFL1 cells were exposed to the nanoparticles,and toxic effects were analyzed by using MTT assay,cellular morphology observation and Hoechst 33 258 staining.Results The results show that the four types of metal oxide nanoparticles lead to cellular mitochondrial dysfunction,morphological modifications and apoptosis at the concentration range of 0.25-1.50 mg/mL and the toxic effects are obviously displayed in dose-dependent manner.ZnO is the most toxic nanomaterials followed by TiO2,SiO2,and Al2O3 nanoparticles in a descending order.Conclusion The results highlight the differential cytotoxicity associated with exposure to ZnO,TiO2,SiO2,and Al2O3 nanoparticles,and suggest an extreme attention to safety utilization of these nanomaterials.

ZHANG Xiao Qiang, YIN Li Hong, TANG Meng, PU Yue Pu. ZnO, TiO2, SiO2, and Al2O3 Nanoparticles-induced Toxic Effects on Human Fetal Lung Fibroblasts[J]. Biomedical and Environmental Sciences, 2011, 24(6): 661-669. doi: 10.3967/0895-3988.2011.06.011
Citation: ZHANG Xiao Qiang, YIN Li Hong, TANG Meng, PU Yue Pu. ZnO, TiO2, SiO2, and Al2O3 Nanoparticles-induced Toxic Effects on Human Fetal Lung Fibroblasts[J]. Biomedical and Environmental Sciences, 2011, 24(6): 661-669. doi: 10.3967/0895-3988.2011.06.011

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return