Volume 25 Issue 3
Jun.  2012
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ZHAI Yi, SHI Xiao Ming, FITZGERALD Simon Michael, QIAN Han Zhu, KRAUS Virginia B, SERENY Melanie, HU Perry, YIN Zhao Xue, XU Jian Wei, ZENG Yi. High Sensitivity C-Reactive Protein Associated with Different Health Predictors in Middle-Aged and oldest old Chinese[J]. Biomedical and Environmental Sciences, 2012, 25(3): 257-266. doi: 10.3967/0895-3988.2012.03.002
Citation: ZHAI Yi, SHI Xiao Ming, FITZGERALD Simon Michael, QIAN Han Zhu, KRAUS Virginia B, SERENY Melanie, HU Perry, YIN Zhao Xue, XU Jian Wei, ZENG Yi. High Sensitivity C-Reactive Protein Associated with Different Health Predictors in Middle-Aged and oldest old Chinese[J]. Biomedical and Environmental Sciences, 2012, 25(3): 257-266. doi: 10.3967/0895-3988.2012.03.002

High Sensitivity C-Reactive Protein Associated with Different Health Predictors in Middle-Aged and oldest old Chinese

doi: 10.3967/0895-3988.2012.03.002
Funds:  This work was supported by National Natural Science Foundation of China(70533010)%NIH(5R24 TW 007988)
  • Objective To describe the distribution of plasma high sensitivity C-reactive protein (hsCRP) and explore the relationship between hsCRP and metabolic risk factors among residents living in longevity areas of China.Methods 268 individuals aged between 40 and 59 years and 506 individuals aged over 90 years were selected from 5 longevity areas of China to participate in a cross section longitudinal cohort study.The participants were interviewed with general health related questionnaire to collect their demographic,behavioral and lifestyle data,as well as their chronic conditions,and meanwhile their physical and biomedical parameters including waist circumference (WC),blood pressure (BP),hsCRP,plasma lipids,and fasting blood glucose (FBG) were measured.Results The median of hsCRP was 0.99 mg/L in the middle-aged group and 1.76 mg/L in the oldest old group.No significant gender difference was observed between the above two groups.Among the oldest old individuals,36.56% had an hsCRP level >3.0 mg/L.The prevalence of high hsCRP was 16.79% in the middle-aged group.The results of stepwise multiple linear regression analyses showed that HDL-C was independently associated with In (hsCRP) concentration in the middle-aged group,whereas In (TG),HDL-C and FBG were correlated after adjustment for gender,study site,smoking,drinking,education and BMI in the oldest old group.Conclusion HDL-C is a stronger predictor of elevated hsCRP than other metabolic factors in the middle-aged population.For the oldest old persons,high TG,low HDL-C,and FBG predict elevated plasma hsCRP.
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High Sensitivity C-Reactive Protein Associated with Different Health Predictors in Middle-Aged and oldest old Chinese

doi: 10.3967/0895-3988.2012.03.002
Funds:  This work was supported by National Natural Science Foundation of China(70533010)%NIH(5R24 TW 007988)

Abstract: Objective To describe the distribution of plasma high sensitivity C-reactive protein (hsCRP) and explore the relationship between hsCRP and metabolic risk factors among residents living in longevity areas of China.Methods 268 individuals aged between 40 and 59 years and 506 individuals aged over 90 years were selected from 5 longevity areas of China to participate in a cross section longitudinal cohort study.The participants were interviewed with general health related questionnaire to collect their demographic,behavioral and lifestyle data,as well as their chronic conditions,and meanwhile their physical and biomedical parameters including waist circumference (WC),blood pressure (BP),hsCRP,plasma lipids,and fasting blood glucose (FBG) were measured.Results The median of hsCRP was 0.99 mg/L in the middle-aged group and 1.76 mg/L in the oldest old group.No significant gender difference was observed between the above two groups.Among the oldest old individuals,36.56% had an hsCRP level >3.0 mg/L.The prevalence of high hsCRP was 16.79% in the middle-aged group.The results of stepwise multiple linear regression analyses showed that HDL-C was independently associated with In (hsCRP) concentration in the middle-aged group,whereas In (TG),HDL-C and FBG were correlated after adjustment for gender,study site,smoking,drinking,education and BMI in the oldest old group.Conclusion HDL-C is a stronger predictor of elevated hsCRP than other metabolic factors in the middle-aged population.For the oldest old persons,high TG,low HDL-C,and FBG predict elevated plasma hsCRP.

ZHAI Yi, SHI Xiao Ming, FITZGERALD Simon Michael, QIAN Han Zhu, KRAUS Virginia B, SERENY Melanie, HU Perry, YIN Zhao Xue, XU Jian Wei, ZENG Yi. High Sensitivity C-Reactive Protein Associated with Different Health Predictors in Middle-Aged and oldest old Chinese[J]. Biomedical and Environmental Sciences, 2012, 25(3): 257-266. doi: 10.3967/0895-3988.2012.03.002
Citation: ZHAI Yi, SHI Xiao Ming, FITZGERALD Simon Michael, QIAN Han Zhu, KRAUS Virginia B, SERENY Melanie, HU Perry, YIN Zhao Xue, XU Jian Wei, ZENG Yi. High Sensitivity C-Reactive Protein Associated with Different Health Predictors in Middle-Aged and oldest old Chinese[J]. Biomedical and Environmental Sciences, 2012, 25(3): 257-266. doi: 10.3967/0895-3988.2012.03.002

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