Volume 25 Issue 3
Jun.  2012
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Ibtissem Ben AMARA, Nejla SOUDANI, Afef TROUDI, Ahmed HAKIM, Khaled Mounir ZEGHAL, Tahia BOUDAWARA, Najiba ZEGHAL. Dimethoate Induced Oxidative Damage and Histopathological Changes in lung of Adult rats: Modulatory Effects of Selenium and/or Vitamin E[J]. Biomedical and Environmental Sciences, 2012, 25(3): 340-351. doi: 10.3967/0895-3988.2012.03.013
Citation: Ibtissem Ben AMARA, Nejla SOUDANI, Afef TROUDI, Ahmed HAKIM, Khaled Mounir ZEGHAL, Tahia BOUDAWARA, Najiba ZEGHAL. Dimethoate Induced Oxidative Damage and Histopathological Changes in lung of Adult rats: Modulatory Effects of Selenium and/or Vitamin E[J]. Biomedical and Environmental Sciences, 2012, 25(3): 340-351. doi: 10.3967/0895-3988.2012.03.013

Dimethoate Induced Oxidative Damage and Histopathological Changes in lung of Adult rats: Modulatory Effects of Selenium and/or Vitamin E

doi: 10.3967/0895-3988.2012.03.013
Funds:  This work was supported by the DGRST grants(Appui à la Recherche Universitaire de Base ARUB 99/UR/08-73)
  • Objective To determine the efficiency of selenium and/or vitamin E to alleviate lung oxidative damage induced by dimethoate,an organophosphorus compound.Methods Adult Wistar rats were exposed during 30 days either to dimethoate (0.2 g/L of drinking water),dimethoate+selenium (0.5 mg/kg of diet),dimethoate+vitamin E (100 mg/kg of diet),or dimet hoate+selenium+vitamin E.Results Exposure to dimethoate caused oxidative stress in lung evidenced by an increase of malondialdehyde,protein carbonyl groups and advanced oxidation protein products.An increase in glutathione peroxidase,superoxide dismutase,catalase and a decrease in acetylcholinesterase and butyrylcholinesterase activities,glutathione,non-protein thiols and vitamins C levels were observed.Histopathological changes in lung tissue were noted as emphysema,hemorrhages and hemosiderin deposits.Co-administration of selenium or vitamin E to the diet of dimethoate treated rats ameliorated the biochemical parameters as well as histological impairments.The joint effect of these elements was more powerful in antagonizing dimethoate-induced lung oxidative damage.Conclusion We concluded that selenium and vitamin E ameliorated the toxic effects of this pesticide in lung tissue suggesting their role as potential antioxidants.
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Dimethoate Induced Oxidative Damage and Histopathological Changes in lung of Adult rats: Modulatory Effects of Selenium and/or Vitamin E

doi: 10.3967/0895-3988.2012.03.013
Funds:  This work was supported by the DGRST grants(Appui à la Recherche Universitaire de Base ARUB 99/UR/08-73)

Abstract: Objective To determine the efficiency of selenium and/or vitamin E to alleviate lung oxidative damage induced by dimethoate,an organophosphorus compound.Methods Adult Wistar rats were exposed during 30 days either to dimethoate (0.2 g/L of drinking water),dimethoate+selenium (0.5 mg/kg of diet),dimethoate+vitamin E (100 mg/kg of diet),or dimet hoate+selenium+vitamin E.Results Exposure to dimethoate caused oxidative stress in lung evidenced by an increase of malondialdehyde,protein carbonyl groups and advanced oxidation protein products.An increase in glutathione peroxidase,superoxide dismutase,catalase and a decrease in acetylcholinesterase and butyrylcholinesterase activities,glutathione,non-protein thiols and vitamins C levels were observed.Histopathological changes in lung tissue were noted as emphysema,hemorrhages and hemosiderin deposits.Co-administration of selenium or vitamin E to the diet of dimethoate treated rats ameliorated the biochemical parameters as well as histological impairments.The joint effect of these elements was more powerful in antagonizing dimethoate-induced lung oxidative damage.Conclusion We concluded that selenium and vitamin E ameliorated the toxic effects of this pesticide in lung tissue suggesting their role as potential antioxidants.

Ibtissem Ben AMARA, Nejla SOUDANI, Afef TROUDI, Ahmed HAKIM, Khaled Mounir ZEGHAL, Tahia BOUDAWARA, Najiba ZEGHAL. Dimethoate Induced Oxidative Damage and Histopathological Changes in lung of Adult rats: Modulatory Effects of Selenium and/or Vitamin E[J]. Biomedical and Environmental Sciences, 2012, 25(3): 340-351. doi: 10.3967/0895-3988.2012.03.013
Citation: Ibtissem Ben AMARA, Nejla SOUDANI, Afef TROUDI, Ahmed HAKIM, Khaled Mounir ZEGHAL, Tahia BOUDAWARA, Najiba ZEGHAL. Dimethoate Induced Oxidative Damage and Histopathological Changes in lung of Adult rats: Modulatory Effects of Selenium and/or Vitamin E[J]. Biomedical and Environmental Sciences, 2012, 25(3): 340-351. doi: 10.3967/0895-3988.2012.03.013

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