Volume 27 Issue 7
Jul.  2014
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SUN BaoQing, CHEN DeHui, ZHENG PeiYan, HUANG HuiMin, LUO WenTing, ZENG Guang Qiao, ZHANG XiaoWen. Allergy-related Evidences in Relation to Serum IgE:Data from the China State Key Laboratory of Respiratory Disease, 2008-2013[J]. Biomedical and Environmental Sciences, 2014, 27(7): 495-505. doi: 10.3967/bes2014.081
Citation: SUN BaoQing, CHEN DeHui, ZHENG PeiYan, HUANG HuiMin, LUO WenTing, ZENG Guang Qiao, ZHANG XiaoWen. Allergy-related Evidences in Relation to Serum IgE:Data from the China State Key Laboratory of Respiratory Disease, 2008-2013[J]. Biomedical and Environmental Sciences, 2014, 27(7): 495-505. doi: 10.3967/bes2014.081

Allergy-related Evidences in Relation to Serum IgE:Data from the China State Key Laboratory of Respiratory Disease, 2008-2013

doi: 10.3967/bes2014.081
Funds:  This study was supported by Guangdong Industry Technology and Development Fund(2011B061200040)%Science Foundation of Guangzhou Medical Univesity(Project 2013A06)%andGuangdong Natural Science Foundation (No. S2013010014728).The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.No additional external funding received for this study
  • ObjectiveTo investigate the serum total IgE (tIgE) and specific IgE (sIgE) to common allergens among allergic patients in Guangzhou, China. Methods7 085 patients were examined for tIgE and sIgE to 15 allergens, based on the protocols of reversed enzyme allergosorbent test and the sandwich enzyme-linked immunosorbent assay. Results3 758(53.04%) patients tested positive for tIgE, and 4 640(65.49%) for sIgE.Der pteronyssinus,Der farinae, eggs, and cow’s milk were the most common allergens leading to higher positive rates of sIgE responses. Several peaks of sensitization were:Der pteronyssinus,Der farinae, and Blomia tropicalis at age 10-12; cow’s milk at age below 3; eggs at age 4-6. The mean level and positive rate of tIgE tended to increase in subjects sensitized to more allergens. Sensitization toDer pteronyssinus (OR, 1.6;P<0.05),Der farinae (OR, 1.5;P<0.05),Blomia tropicalis (OR, 1.4;P<0.05), Blattella germanica (OR, 1.5;P<0.05), cow’s milk (OR, 1.3;P<0.05), and soy beans (OR, 2.0;P<0.05) were independently correlated with allergy-related conditions in preliminary diagnosis. ConclusionThe major allergens in Guangzhou includeDer pteronyssinus, Der farinae, cow’s milk, and eggs. Sensitization to these allergens appears to be predictors of allergy-related disorder.
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Allergy-related Evidences in Relation to Serum IgE:Data from the China State Key Laboratory of Respiratory Disease, 2008-2013

doi: 10.3967/bes2014.081
Funds:  This study was supported by Guangdong Industry Technology and Development Fund(2011B061200040)%Science Foundation of Guangzhou Medical Univesity(Project 2013A06)%andGuangdong Natural Science Foundation (No. S2013010014728).The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.No additional external funding received for this study

Abstract: ObjectiveTo investigate the serum total IgE (tIgE) and specific IgE (sIgE) to common allergens among allergic patients in Guangzhou, China. Methods7 085 patients were examined for tIgE and sIgE to 15 allergens, based on the protocols of reversed enzyme allergosorbent test and the sandwich enzyme-linked immunosorbent assay. Results3 758(53.04%) patients tested positive for tIgE, and 4 640(65.49%) for sIgE.Der pteronyssinus,Der farinae, eggs, and cow’s milk were the most common allergens leading to higher positive rates of sIgE responses. Several peaks of sensitization were:Der pteronyssinus,Der farinae, and Blomia tropicalis at age 10-12; cow’s milk at age below 3; eggs at age 4-6. The mean level and positive rate of tIgE tended to increase in subjects sensitized to more allergens. Sensitization toDer pteronyssinus (OR, 1.6;P<0.05),Der farinae (OR, 1.5;P<0.05),Blomia tropicalis (OR, 1.4;P<0.05), Blattella germanica (OR, 1.5;P<0.05), cow’s milk (OR, 1.3;P<0.05), and soy beans (OR, 2.0;P<0.05) were independently correlated with allergy-related conditions in preliminary diagnosis. ConclusionThe major allergens in Guangzhou includeDer pteronyssinus, Der farinae, cow’s milk, and eggs. Sensitization to these allergens appears to be predictors of allergy-related disorder.

SUN BaoQing, CHEN DeHui, ZHENG PeiYan, HUANG HuiMin, LUO WenTing, ZENG Guang Qiao, ZHANG XiaoWen. Allergy-related Evidences in Relation to Serum IgE:Data from the China State Key Laboratory of Respiratory Disease, 2008-2013[J]. Biomedical and Environmental Sciences, 2014, 27(7): 495-505. doi: 10.3967/bes2014.081
Citation: SUN BaoQing, CHEN DeHui, ZHENG PeiYan, HUANG HuiMin, LUO WenTing, ZENG Guang Qiao, ZHANG XiaoWen. Allergy-related Evidences in Relation to Serum IgE:Data from the China State Key Laboratory of Respiratory Disease, 2008-2013[J]. Biomedical and Environmental Sciences, 2014, 27(7): 495-505. doi: 10.3967/bes2014.081

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