Volume 28 Issue 7
Jul.  2015
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Article Navigation >  Biomedical and Environmental Sciences  > 2015  >  28(7): 510-517

YOU Hai Fei, ZHAO Jing Zhi, ZHAI Yu Jia, YIN Lei, PANG Chao, LUO Xin Ping, ZHANG Ming, WANG Jin Jin, LI Lin Lin, WANG Yan, WANG Qian, WANG Bing Yuan, REN Yong Cheng, HU Dong Sheng. Association between Low-density Lipoprotein Receptor-related Protein 5 Polymorphisms and Type 2 Diabetes Mellitus in Han Chinese:a Case-control Study[J]. Biomedical and Environmental Sciences, 2015, 28(7): 510-517. doi: 10.3967/bes2015.073
Citation: YOU Hai Fei, ZHAO Jing Zhi, ZHAI Yu Jia, YIN Lei, PANG Chao, LUO Xin Ping, ZHANG Ming, WANG Jin Jin, LI Lin Lin, WANG Yan, WANG Qian, WANG Bing Yuan, REN Yong Cheng, HU Dong Sheng. Association between Low-density Lipoprotein Receptor-related Protein 5 Polymorphisms and Type 2 Diabetes Mellitus in Han Chinese:a Case-control Study[J]. Biomedical and Environmental Sciences, 2015, 28(7): 510-517. doi: 10.3967/bes2015.073
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Association between Low-density Lipoprotein Receptor-related Protein 5 Polymorphisms and Type 2 Diabetes Mellitus in Han Chinese:a Case-control Study

doi: 10.3967/bes2015.073

  • Department of Blood Transfusion, Xijing Hospital, The Fourth Military Medical University, Xi’an 710023, Shannxi, China

  • Military Hospital of Henan Province, Zhengzhou 450003, Henan, China

  • Department of Public Health Surveillance & Advisory, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, Zhejiang, China

  • Shenzhen University School of Medicine, Shenzhen 518060, Guangdong, China

  • Discipline of Public Health and Preventive Medicine, Center of Preventive Medicine Research and Assessment, Henan University of Traditional Chinese Medicine, Zhengzhou 450008, Henan, China

  • Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China

Funds:  This study was supported by the National Natural Science Foundation of China(81072359)%Natural Science Foundation of Guangdong Province(S2013010016791)%Science and Technology Development Foundation of Shenzhen(JCYJ20120613112221107 and JCYJ20130326110246234)%Natural Science Foundation of Shenzhen University(801-00035911)
  • Objective To investigate the association between low-density lipoprotein receptor-related protein 5 (LRP5) variants (rs12363572 and rs4930588) and type 2 diabetes mellitus (T2DM) in Han Chinese.
    Methods A total of 1842 T2DM cases (507 newly diagnosed cases and 1335 previously diagnosed cases) and 7777 controls were included in this case-control study. PCR-RFLP was conducted to detect the genotype of the two single nucleotide polymorphisms (SNPs). Odds ratios (ORs) and 95%confidence intervals (95%CIs) were calculated to describe the strength of the association by logistic regression.
    Results In the study subjects, neither rs12363572 nor rs4930588 was significantly associated with T2DM, even after adjusting for relevant covariates. When stratified by body mass index (BMI), the two SNPs were also not associated with T2DM. Among the 3 common haplotypes, only haplotype TT was associated with reduced risk of T2DM (OR 0.820, 95% CI 0.732-0.919). In addition, rs12363572 was associated with BMI (P<0.001) and rs4930588 was associated with triglyceride levels (P=0.043) in 507 newly diagnosed T2DM cases but not in healthy controls.
    Conclusion No LRP5 variant was found to be associated with T2DM in Han Chinese, but haplotype TT was found to be associated with T2DM.
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Association between Low-density Lipoprotein Receptor-related Protein 5 Polymorphisms and Type 2 Diabetes Mellitus in Han Chinese:a Case-control Study

doi: 10.3967/bes2015.073
  • Department of Blood Transfusion, Xijing Hospital, The Fourth Military Medical University, Xi’an 710023, Shannxi, China
  • Military Hospital of Henan Province, Zhengzhou 450003, Henan, China
  • Department of Public Health Surveillance & Advisory, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, Zhejiang, China
  • Shenzhen University School of Medicine, Shenzhen 518060, Guangdong, China
  • Discipline of Public Health and Preventive Medicine, Center of Preventive Medicine Research and Assessment, Henan University of Traditional Chinese Medicine, Zhengzhou 450008, Henan, China
  • Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China
Funds:  This study was supported by the National Natural Science Foundation of China(81072359)%Natural Science Foundation of Guangdong Province(S2013010016791)%Science and Technology Development Foundation of Shenzhen(JCYJ20120613112221107 and JCYJ20130326110246234)%Natural Science Foundation of Shenzhen University(801-00035911)

Abstract: Objective To investigate the association between low-density lipoprotein receptor-related protein 5 (LRP5) variants (rs12363572 and rs4930588) and type 2 diabetes mellitus (T2DM) in Han Chinese.
Methods A total of 1842 T2DM cases (507 newly diagnosed cases and 1335 previously diagnosed cases) and 7777 controls were included in this case-control study. PCR-RFLP was conducted to detect the genotype of the two single nucleotide polymorphisms (SNPs). Odds ratios (ORs) and 95%confidence intervals (95%CIs) were calculated to describe the strength of the association by logistic regression.
Results In the study subjects, neither rs12363572 nor rs4930588 was significantly associated with T2DM, even after adjusting for relevant covariates. When stratified by body mass index (BMI), the two SNPs were also not associated with T2DM. Among the 3 common haplotypes, only haplotype TT was associated with reduced risk of T2DM (OR 0.820, 95% CI 0.732-0.919). In addition, rs12363572 was associated with BMI (P<0.001) and rs4930588 was associated with triglyceride levels (P=0.043) in 507 newly diagnosed T2DM cases but not in healthy controls.
Conclusion No LRP5 variant was found to be associated with T2DM in Han Chinese, but haplotype TT was found to be associated with T2DM.

YOU Hai Fei, ZHAO Jing Zhi, ZHAI Yu Jia, YIN Lei, PANG Chao, LUO Xin Ping, ZHANG Ming, WANG Jin Jin, LI Lin Lin, WANG Yan, WANG Qian, WANG Bing Yuan, REN Yong Cheng, HU Dong Sheng. Association between Low-density Lipoprotein Receptor-related Protein 5 Polymorphisms and Type 2 Diabetes Mellitus in Han Chinese:a Case-control Study[J]. Biomedical and Environmental Sciences, 2015, 28(7): 510-517. doi: 10.3967/bes2015.073
Citation: YOU Hai Fei, ZHAO Jing Zhi, ZHAI Yu Jia, YIN Lei, PANG Chao, LUO Xin Ping, ZHANG Ming, WANG Jin Jin, LI Lin Lin, WANG Yan, WANG Qian, WANG Bing Yuan, REN Yong Cheng, HU Dong Sheng. Association between Low-density Lipoprotein Receptor-related Protein 5 Polymorphisms and Type 2 Diabetes Mellitus in Han Chinese:a Case-control Study[J]. Biomedical and Environmental Sciences, 2015, 28(7): 510-517. doi: 10.3967/bes2015.073
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