Volume 29 Issue 6
Jun.  2016
Turn off MathJax
Article Contents

SONG Jun, ZOU Shu Rong, GUO Chang Yi, ZANG Jia Jie, ZHU Zhen Ni, MI Ming, HUANG Cui Hua, YU Hui Ting, LU Xi, RUAN Ye, WU Fan. Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study[J]. Biomedical and Environmental Sciences, 2016, 29(6): 398-407. doi: 10.3967/bes2016.052
Citation: SONG Jun, ZOU Shu Rong, GUO Chang Yi, ZANG Jia Jie, ZHU Zhen Ni, MI Ming, HUANG Cui Hua, YU Hui Ting, LU Xi, RUAN Ye, WU Fan. Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study[J]. Biomedical and Environmental Sciences, 2016, 29(6): 398-407. doi: 10.3967/bes2016.052

Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study

doi: 10.3967/bes2016.052
Funds:  This study was supported by Shanghai Municipal health Bureau(number 20134332)%the research grants of the Shanghai Municipal Bureau of Health(number 20134053)%Health Fields Specific Research Grant(201202012)%the Major Project of Shanghai Municipal Science and Technology Commission(11DJ1400202)%the four grants from Key Discipline of Shanghai Public Health-Food and Nutrition Sciences(12GWZX0702)%Shanghai Rising-Star Program(15YF1411100)
  • Objective This study was designed to evaluate the prevalence of thyroid nodules (TNs) and its relationship with urine iodine concentrations (UICs) after the regional rapid economic growth and lifestyle changes.
    Methods A cross-sectional survey was conducted in the general population aged 15-69 years. A questionnaire regarding general and personal characteristics and relevant information was administered. Ultrasonography of the thyroid was performed, and serum triiodothyronine (T3), tetraiodothyronine (T4), serum thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free tetraiodothyronine (FT4), thyroglobulin antibody (TgAb), thyroid peroxidase antibody (TPOAb), and TSH receptor antibody (TRAb) levels were measured for each individual subject.
    Results The prevalence rates of TNs in the whole population, females and males were 27.76%, 34.04%, and 21.60%, respectively. The prevalence of multiple nodules increased with age, whereas the prevalence peaks differed between males and females. The median UICs in the whole population and females with non-TNs were higher than those of subjects with TNs (P=0.0035, P=0.0068). The median UICs in subjects with a single TN were higher than those in subjects with multiple TNs (P=0.0164, P=0.0127). The result showed a U-shaped curve relationship between UIC and prevalence of TNs. The prevalence of TNs was the lowest when the UIC was 140-400 μg/L.
    Conclusion The prevalence of TNs was nearly 30%and increased with age. The relationship between UIC and prevalence of TNs is U-shaped, with an increase in risk when the UIC was <140 μg/L and>400 μg/L. Very low or high UIC levels need attention and correction.
  • 加载中
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(1498) PDF downloads(135) Cited by()

Proportional views
Related

Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study

doi: 10.3967/bes2016.052
Funds:  This study was supported by Shanghai Municipal health Bureau(number 20134332)%the research grants of the Shanghai Municipal Bureau of Health(number 20134053)%Health Fields Specific Research Grant(201202012)%the Major Project of Shanghai Municipal Science and Technology Commission(11DJ1400202)%the four grants from Key Discipline of Shanghai Public Health-Food and Nutrition Sciences(12GWZX0702)%Shanghai Rising-Star Program(15YF1411100)

Abstract: Objective This study was designed to evaluate the prevalence of thyroid nodules (TNs) and its relationship with urine iodine concentrations (UICs) after the regional rapid economic growth and lifestyle changes.
Methods A cross-sectional survey was conducted in the general population aged 15-69 years. A questionnaire regarding general and personal characteristics and relevant information was administered. Ultrasonography of the thyroid was performed, and serum triiodothyronine (T3), tetraiodothyronine (T4), serum thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free tetraiodothyronine (FT4), thyroglobulin antibody (TgAb), thyroid peroxidase antibody (TPOAb), and TSH receptor antibody (TRAb) levels were measured for each individual subject.
Results The prevalence rates of TNs in the whole population, females and males were 27.76%, 34.04%, and 21.60%, respectively. The prevalence of multiple nodules increased with age, whereas the prevalence peaks differed between males and females. The median UICs in the whole population and females with non-TNs were higher than those of subjects with TNs (P=0.0035, P=0.0068). The median UICs in subjects with a single TN were higher than those in subjects with multiple TNs (P=0.0164, P=0.0127). The result showed a U-shaped curve relationship between UIC and prevalence of TNs. The prevalence of TNs was the lowest when the UIC was 140-400 μg/L.
Conclusion The prevalence of TNs was nearly 30%and increased with age. The relationship between UIC and prevalence of TNs is U-shaped, with an increase in risk when the UIC was <140 μg/L and>400 μg/L. Very low or high UIC levels need attention and correction.

SONG Jun, ZOU Shu Rong, GUO Chang Yi, ZANG Jia Jie, ZHU Zhen Ni, MI Ming, HUANG Cui Hua, YU Hui Ting, LU Xi, RUAN Ye, WU Fan. Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study[J]. Biomedical and Environmental Sciences, 2016, 29(6): 398-407. doi: 10.3967/bes2016.052
Citation: SONG Jun, ZOU Shu Rong, GUO Chang Yi, ZANG Jia Jie, ZHU Zhen Ni, MI Ming, HUANG Cui Hua, YU Hui Ting, LU Xi, RUAN Ye, WU Fan. Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study[J]. Biomedical and Environmental Sciences, 2016, 29(6): 398-407. doi: 10.3967/bes2016.052

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return