Volume 29 Issue 7
Jul.  2016
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Mohammad Naderi, Mohammad Hashemi, Gholamreza Bahari. Lack of Association between rs4331426 Polymorphism in the Chr18q11.2 Locus and Pulmonary Tuberculosis in an Iranian Population[J]. Biomedical and Environmental Sciences, 2016, 29(7): 516-520. doi: 10.3967/bes2016.067
Citation: Mohammad Naderi, Mohammad Hashemi, Gholamreza Bahari. Lack of Association between rs4331426 Polymorphism in the Chr18q11.2 Locus and Pulmonary Tuberculosis in an Iranian Population[J]. Biomedical and Environmental Sciences, 2016, 29(7): 516-520. doi: 10.3967/bes2016.067

Lack of Association between rs4331426 Polymorphism in the Chr18q11.2 Locus and Pulmonary Tuberculosis in an Iranian Population

doi: 10.3967/bes2016.067
Funds:  This work was funded by a research grant from Zahedan University of Medical Sciences
  • Objective The effect of rs4331426 polymorphism in the Chr18q11.2 locus on pulmonary tuberculosis (PTB) risk was evaluated.
    Methods This case-control study included 208 PTB patients and 204 healthy subjects. Genotyping of the rs4331426 variant was conducted using polymerase chain reaction restriction fragment length polymorphism.
    Results The frequencies of genotypes AA, AG, and GG polymorphisms were 83.1%, 15.9%, and 1.0% in the PTB group and 84.3%, 15.2%, and 0.5% in the control group, respectively. The frequency of the minor (G) allele was 8.9% in the PTB group and 8.1% in controls. Neither genotype nor allele frequencies of the rs4331426 variant showed statistically significant differences between PTB and controls. In addition, stratification by sex showed no significant association between the rs4331426 variant and PTB risk in males or females.
    Conclusion In conclusion, the results of this study do not support an association between the rs4331426 polymorphism and risk of PTB in an Iranian population.
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Lack of Association between rs4331426 Polymorphism in the Chr18q11.2 Locus and Pulmonary Tuberculosis in an Iranian Population

doi: 10.3967/bes2016.067
Funds:  This work was funded by a research grant from Zahedan University of Medical Sciences

Abstract: Objective The effect of rs4331426 polymorphism in the Chr18q11.2 locus on pulmonary tuberculosis (PTB) risk was evaluated.
Methods This case-control study included 208 PTB patients and 204 healthy subjects. Genotyping of the rs4331426 variant was conducted using polymerase chain reaction restriction fragment length polymorphism.
Results The frequencies of genotypes AA, AG, and GG polymorphisms were 83.1%, 15.9%, and 1.0% in the PTB group and 84.3%, 15.2%, and 0.5% in the control group, respectively. The frequency of the minor (G) allele was 8.9% in the PTB group and 8.1% in controls. Neither genotype nor allele frequencies of the rs4331426 variant showed statistically significant differences between PTB and controls. In addition, stratification by sex showed no significant association between the rs4331426 variant and PTB risk in males or females.
Conclusion In conclusion, the results of this study do not support an association between the rs4331426 polymorphism and risk of PTB in an Iranian population.

Mohammad Naderi, Mohammad Hashemi, Gholamreza Bahari. Lack of Association between rs4331426 Polymorphism in the Chr18q11.2 Locus and Pulmonary Tuberculosis in an Iranian Population[J]. Biomedical and Environmental Sciences, 2016, 29(7): 516-520. doi: 10.3967/bes2016.067
Citation: Mohammad Naderi, Mohammad Hashemi, Gholamreza Bahari. Lack of Association between rs4331426 Polymorphism in the Chr18q11.2 Locus and Pulmonary Tuberculosis in an Iranian Population[J]. Biomedical and Environmental Sciences, 2016, 29(7): 516-520. doi: 10.3967/bes2016.067

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