Volume 23 Issue 4
Aug.  2010
Turn off MathJax
Article Contents

JELENA STOSIC, IVANA MIRKOV, SANDRA BELIJ, MIROSLAV NIKOLIC, ALEKSANDRA POPOV, DRAGAN KATARANOVSKI, MILENA KATARANOVSKI. Gender Differences in Pulmonary Inflammation Following Systemic Cadmium Administration in Rats[J]. Biomedical and Environmental Sciences, 2010, 23(4): 293-299.
Citation: JELENA STOSIC, IVANA MIRKOV, SANDRA BELIJ, MIROSLAV NIKOLIC, ALEKSANDRA POPOV, DRAGAN KATARANOVSKI, MILENA KATARANOVSKI. Gender Differences in Pulmonary Inflammation Following Systemic Cadmium Administration in Rats[J]. Biomedical and Environmental Sciences, 2010, 23(4): 293-299.

Gender Differences in Pulmonary Inflammation Following Systemic Cadmium Administration in Rats

  • Objective To examine the presence of gender differences in pulmonary inflammation evoked by acute systemic cadmium administration in rats. Methods Presence of basic indicators of lung inflammation (inflammatory cytokine lung content, leukocyte infiltration and activity of cells recovered from lungs by enzyme digestion) was analyzed and compared in animals of the two sexes. Results Intraperitoneal administration of cadmium (1.0 mg/kg) resulted in higher cadmium content in lungs of female rats. Higher tumor necrosis factor (TNF) content was noted in lung homogenates of male rats, while interleukin-6 (IL-6) content was slightly, but signifaicantly greater in lungs of female rats. Increased leukocyte infiltration was observed in lungs of male rats, mainly due to neutrophils. Increased responsiveness to phorbol myristate acetate (PMA)stimulation was noted in cells recovered from lungs of male rats. Rise in intracellulgr content of myeloperoxidase (MPO) was noted in lung cells from cadmium-treated rats of both sexes, but higher in cells from male rats. Conclusion Presented data documented a more intense pulmonary inflammatory response to systemic cadmium administration in males, with higher IL-6levels in lungs of female individuals. These sex differences in proinflamatory activity of cadmium in lungs should be taken into consideration in studying the remote toxicity of this heavy metal.
  • 加载中
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(1062) PDF downloads(13) Cited by()

Proportional views
Related

Gender Differences in Pulmonary Inflammation Following Systemic Cadmium Administration in Rats

Abstract: Objective To examine the presence of gender differences in pulmonary inflammation evoked by acute systemic cadmium administration in rats. Methods Presence of basic indicators of lung inflammation (inflammatory cytokine lung content, leukocyte infiltration and activity of cells recovered from lungs by enzyme digestion) was analyzed and compared in animals of the two sexes. Results Intraperitoneal administration of cadmium (1.0 mg/kg) resulted in higher cadmium content in lungs of female rats. Higher tumor necrosis factor (TNF) content was noted in lung homogenates of male rats, while interleukin-6 (IL-6) content was slightly, but signifaicantly greater in lungs of female rats. Increased leukocyte infiltration was observed in lungs of male rats, mainly due to neutrophils. Increased responsiveness to phorbol myristate acetate (PMA)stimulation was noted in cells recovered from lungs of male rats. Rise in intracellulgr content of myeloperoxidase (MPO) was noted in lung cells from cadmium-treated rats of both sexes, but higher in cells from male rats. Conclusion Presented data documented a more intense pulmonary inflammatory response to systemic cadmium administration in males, with higher IL-6levels in lungs of female individuals. These sex differences in proinflamatory activity of cadmium in lungs should be taken into consideration in studying the remote toxicity of this heavy metal.

JELENA STOSIC, IVANA MIRKOV, SANDRA BELIJ, MIROSLAV NIKOLIC, ALEKSANDRA POPOV, DRAGAN KATARANOVSKI, MILENA KATARANOVSKI. Gender Differences in Pulmonary Inflammation Following Systemic Cadmium Administration in Rats[J]. Biomedical and Environmental Sciences, 2010, 23(4): 293-299.
Citation: JELENA STOSIC, IVANA MIRKOV, SANDRA BELIJ, MIROSLAV NIKOLIC, ALEKSANDRA POPOV, DRAGAN KATARANOVSKI, MILENA KATARANOVSKI. Gender Differences in Pulmonary Inflammation Following Systemic Cadmium Administration in Rats[J]. Biomedical and Environmental Sciences, 2010, 23(4): 293-299.

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return