Volume 22 Issue 3
Jun.  2009
Turn off MathJax
Article Contents

WEN-ZHONG ZHANG, WEN-MING CUI, KIN ZHANG, WEI WANG, XU-DONG JIA, XIAO-PENG ZHANG, NING LI. Subchronic Toxicity Study on Soy Isoflavones in Rats1[J]. Biomedical and Environmental Sciences, 2009, 22(3): 259-264.
Citation: WEN-ZHONG ZHANG, WEN-MING CUI, KIN ZHANG, WEI WANG, XU-DONG JIA, XIAO-PENG ZHANG, NING LI. Subchronic Toxicity Study on Soy Isoflavones in Rats1[J]. Biomedical and Environmental Sciences, 2009, 22(3): 259-264.

Subchronic Toxicity Study on Soy Isoflavones in Rats1

Funds:  the Project of the Eleventh Five-Year Plan of China(2006BAK02A07)
  • Objective To investigate the subchronic toxicity of soy isoflavones (SIF) in male rats. Method Fifty Sprague-Dawley rats were randomly divided into 5 groups,10 rats per group.SIF were given to rats in different groups by gavage at dose of 0,0.2,0.5,1.5,and 4.5 g/kg bw,respectively for 13 weeks.Clinical manifestations,body weight,and food consumption were observed weekly.At the end of the study,urinalysis,hematology,clinical chemistry,total testosterone,and follicle-stimulating hormone were tested,and histopathological examinations were performed. Results No mortality,ophthalmic abnormalities or treatment-related clinical signs were identified during the study.As compared with the control group,significantly lower body weights and food consumption were observed in 1.5 and 4.5 g/kg bw groups.In clinical chemistry tests,triglyceride was significantly decreased and high-density lipoprotein cholesterol was significantly increased in all SIF-treated groups.Total testosterone levels were significantly lower in 0.50,1.50,and 4.5 g/kg bw dose groups than in the control group.Microscopic examination showed that the mammary glands exhibited hyperplasia and excreted latex in rats of the 4.5 g/kg bw group.No changes attributable to treatment of SIF in other parameters were found. Conclusion SIF at high dosages caused significant endocrine disruption in male rats.The no observed adverse effect level (NOAEL) of SIF to male rats in this study is considered to be 0.20 g/kg bw.
  • 加载中
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(884) PDF downloads(25) Cited by()

Proportional views
Related

Subchronic Toxicity Study on Soy Isoflavones in Rats1

Funds:  the Project of the Eleventh Five-Year Plan of China(2006BAK02A07)

Abstract: Objective To investigate the subchronic toxicity of soy isoflavones (SIF) in male rats. Method Fifty Sprague-Dawley rats were randomly divided into 5 groups,10 rats per group.SIF were given to rats in different groups by gavage at dose of 0,0.2,0.5,1.5,and 4.5 g/kg bw,respectively for 13 weeks.Clinical manifestations,body weight,and food consumption were observed weekly.At the end of the study,urinalysis,hematology,clinical chemistry,total testosterone,and follicle-stimulating hormone were tested,and histopathological examinations were performed. Results No mortality,ophthalmic abnormalities or treatment-related clinical signs were identified during the study.As compared with the control group,significantly lower body weights and food consumption were observed in 1.5 and 4.5 g/kg bw groups.In clinical chemistry tests,triglyceride was significantly decreased and high-density lipoprotein cholesterol was significantly increased in all SIF-treated groups.Total testosterone levels were significantly lower in 0.50,1.50,and 4.5 g/kg bw dose groups than in the control group.Microscopic examination showed that the mammary glands exhibited hyperplasia and excreted latex in rats of the 4.5 g/kg bw group.No changes attributable to treatment of SIF in other parameters were found. Conclusion SIF at high dosages caused significant endocrine disruption in male rats.The no observed adverse effect level (NOAEL) of SIF to male rats in this study is considered to be 0.20 g/kg bw.

WEN-ZHONG ZHANG, WEN-MING CUI, KIN ZHANG, WEI WANG, XU-DONG JIA, XIAO-PENG ZHANG, NING LI. Subchronic Toxicity Study on Soy Isoflavones in Rats1[J]. Biomedical and Environmental Sciences, 2009, 22(3): 259-264.
Citation: WEN-ZHONG ZHANG, WEN-MING CUI, KIN ZHANG, WEI WANG, XU-DONG JIA, XIAO-PENG ZHANG, NING LI. Subchronic Toxicity Study on Soy Isoflavones in Rats1[J]. Biomedical and Environmental Sciences, 2009, 22(3): 259-264.

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return