Vascular and Morphogenetic Abnormalities Associated with Exposure of Cigarette Smoke Condensate during Chicken and Murine Embryogenesis

SOHAIL EJAZ; AHMED EJAZ; AMARA SOHAIL; CHAN WOONG LIM

PDF
Cite
Share

facebook

twitter

google

linkedin

Volume 23 Issue 4

Aug. 2010

Turn off MathJax

Article Contents

Article Navigation > Biomedical and Environmental Sciences > 2010 > 23(4): 305-311

SOHAIL EJAZ, AHMED EJAZ, AMARA SOHAIL, CHAN WOONG LIM. Vascular and Morphogenetic Abnormalities Associated with Exposure of Cigarette Smoke Condensate during Chicken and Murine Embryogenesis[J]. Biomedical and Environmental Sciences, 2010, 23(4): 305-311.

Citation:

SOHAIL EJAZ, AHMED EJAZ, AMARA SOHAIL, CHAN WOONG LIM. Vascular and Morphogenetic Abnormalities Associated with Exposure of Cigarette Smoke Condensate during Chicken and Murine Embryogenesis[J]. Biomedical and Environmental Sciences, 2010, 23(4): 305-311.

Vascular and Morphogenetic Abnormalities Associated with Exposure of Cigarette Smoke Condensate during Chicken and Murine Embryogenesis

Department of Clinical Neurosciences,Neurology Unit,Addenbrookes Hospital,University of Cambridge,UK
District Headquarter Hospital,Gujranwala,Pakistan
Government Social Security Hospital,Gujranwala,Pakistan
Biosafety Research Institute and College of Veterinary Medicine,Chonbuk National University,Jeonju,561-756,South Korea

Funds: the grant from Post Doctor Program, Chonbuk National University(2008)

Abstract

Objective Embryonic movements (EM) and angiogenesis pathways are evolutionarily conserved mechanisms which are essential for proper embryonic development. Deviations in these processes by exposure to cigarette smoke condensate (CSC)may cause vascular and morphogenetic disorders. Methods Using chicken and mouse embryos, we have demonstrated the in vivo effects of CSC on EM, vascular development, and organogenesis. Results Examination of the CSC exposed chicken embryos revealed a significant reduction in EM, stunted growth, deviated pattern of blood vessels, hemorrhages, and localized necrosis. Likewise, mouse embryos that were exposed to CSC at E8.5 and E9.5 died between El 1.5 and E12.5, respectively.These mouse embryos showed defects in morphogenesis and remodeling of the embryonic vasculature, while littermate controls showed normal development.Conclusion Cigarette smoking during pregnancy is fatal for growing embryos. CSC may induce the remodeling of embryonic vasculature, leading to various pathologies.
- Angiogenesis,
- Embryonic movements,
- Cigarette smoke condensate,
- Vascular remodeling
References
Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Get Citation

PDF

XML

Article Metrics

Article views(878) PDF downloads(9) Cited by()

Proportional views

Vascular and Morphogenetic Abnormalities Associated with Exposure of Cigarette Smoke Condensate during Chicken and Murine Embryogenesis

Department of Clinical Neurosciences,Neurology Unit,Addenbrookes Hospital,University of Cambridge,UK

District Headquarter Hospital,Gujranwala,Pakistan

Government Social Security Hospital,Gujranwala,Pakistan

Biosafety Research Institute and College of Veterinary Medicine,Chonbuk National University,Jeonju,561-756,South Korea

Funds: the grant from Post Doctor Program, Chonbuk National University(2008)

Key words:

Abstract: Objective Embryonic movements (EM) and angiogenesis pathways are evolutionarily conserved mechanisms which are essential for proper embryonic development. Deviations in these processes by exposure to cigarette smoke condensate (CSC)may cause vascular and morphogenetic disorders. Methods Using chicken and mouse embryos, we have demonstrated the in vivo effects of CSC on EM, vascular development, and organogenesis. Results Examination of the CSC exposed chicken embryos revealed a significant reduction in EM, stunted growth, deviated pattern of blood vessels, hemorrhages, and localized necrosis. Likewise, mouse embryos that were exposed to CSC at E8.5 and E9.5 died between El 1.5 and E12.5, respectively.These mouse embryos showed defects in morphogenesis and remodeling of the embryonic vasculature, while littermate controls showed normal development.Conclusion Cigarette smoking during pregnancy is fatal for growing embryos. CSC may induce the remodeling of embryonic vasculature, leading to various pathologies.

Citation:

SOHAIL EJAZ, AHMED EJAZ, AMARA SOHAIL, CHAN WOONG LIM. Vascular and Morphogenetic Abnormalities Associated with Exposure of Cigarette Smoke Condensate during Chicken and Murine Embryogenesis[J]. Biomedical and Environmental Sciences, 2010, 23(4): 305-311.