LI ShuGuang; DAI JiCan; ZHANG LiQian; ZHANG Jing; ZHANG ZiQiang; CHEN Bo

doi:10.3967/0895-3988.2011.01.004

An Association of Elevated Serum Prolactin with Phthalate Exposure in Adult Men

LI ShuGuang, DAI JiCan, ZHANG LiQian, ZHANG Jing, ZHANG ZiQiang, CHEN Bo

文章导航 > Biomedical and Environmental Sciences > 2011 > 24(1): 31-39

LI ShuGuang, DAI JiCan, ZHANG LiQian, ZHANG Jing, ZHANG ZiQiang, CHEN Bo. An Association of Elevated Serum Prolactin with Phthalate Exposure in Adult Men[J]. Biomedical and Environmental Sciences, 2011, 24(1): 31-39. doi: 10.3967/0895-3988.2011.01.004

Citation:

LI ShuGuang, DAI JiCan, ZHANG LiQian, ZHANG Jing, ZHANG ZiQiang, CHEN Bo. An Association of Elevated Serum Prolactin with Phthalate Exposure in Adult Men[J]. Biomedical and Environmental Sciences, 2011, 24(1): 31-39. doi: 10.3967/0895-3988.2011.01.004

doi: 10.3967/0895-3988.2011.01.004

基金项目: the Shanghai Municipal Health Bureau(08GWQ003)%the Shanghai Population and Family Planning Commission(2007JG05)

An Association of Elevated Serum Prolactin with Phthalate Exposure in Adult Men

School of Public Health, Fudan University, Shanghai 200032, China
Department of Urology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200001, China
Tongji University Medical School, Shanghai 200092, China

Funds: the Shanghai Municipal Health Bureau(08GWQ003)%the Shanghai Population and Family Planning Commission(2007JG05)

摘要: Objective To investigate the associations of hormone circulation with phthalate exposure in adult men.Methods Semen and serum samples were collected from 118 men who were suspected of infertility.Phthalate diesters including dibutyl phthalate (DBP) and diethylhexyl phthalate (DEHP) in both semen and serum samples were measured, along with serum levels of follicle stimulating hormone (FSH),luteinizing hormone (LH), testosterone (T), estradiol (E2) and prolactin (PRL).Results Serum PRL was positively associated with serum DBP and DEHP and semen DEHP in all models of Spearman correlation, linear regression and binary logistic regression. In linear regression models adjusted for potential confounders and excluding subjects with undetectable phthalates, a 10-fold increase in semen DEHP was associated with a 23% increase in serum PRL, as well as a 26% increase in serum DBP and a 20% increase in serum DEHP. In logistic regression models all subjects demonstrated a dose-response relationship between above reference value PRL and semen DEHP (odds ratio per tertile adjusted for potential confounders = 1.0, 1.70, 3.50; Pfor trend = 0.01), and serum DBP (1.0, 1.10, 2.62;P for trend = 0.04), and serum DEHP (1.0, 1.46, 4.69; P for trend ＜ 0.01). A positive correlation between serum estradiol and semen DEHP (linear regression), and an inverse correlation between semen DBP and serum testosterone and T:E2 ratio (Spearman correlation) were also established.Conclusions Serum PRL is suggested to be positively associated with both DBP and DEHP exposure in adult men.
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Abstract: Objective To investigate the associations of hormone circulation with phthalate exposure in adult men.Methods Semen and serum samples were collected from 118 men who were suspected of infertility.Phthalate diesters including dibutyl phthalate (DBP) and diethylhexyl phthalate (DEHP) in both semen and serum samples were measured, along with serum levels of follicle stimulating hormone (FSH),luteinizing hormone (LH), testosterone (T), estradiol (E2) and prolactin (PRL).Results Serum PRL was positively associated with serum DBP and DEHP and semen DEHP in all models of Spearman correlation, linear regression and binary logistic regression. In linear regression models adjusted for potential confounders and excluding subjects with undetectable phthalates, a 10-fold increase in semen DEHP was associated with a 23% increase in serum PRL, as well as a 26% increase in serum DBP and a 20% increase in serum DEHP. In logistic regression models all subjects demonstrated a dose-response relationship between above reference value PRL and semen DEHP (odds ratio per tertile adjusted for potential confounders = 1.0, 1.70, 3.50; Pfor trend = 0.01), and serum DBP (1.0, 1.10, 2.62;P for trend = 0.04), and serum DEHP (1.0, 1.46, 4.69; P for trend ＜ 0.01). A positive correlation between serum estradiol and semen DEHP (linear regression), and an inverse correlation between semen DBP and serum testosterone and T:E2 ratio (Spearman correlation) were also established.Conclusions Serum PRL is suggested to be positively associated with both DBP and DEHP exposure in adult men.
- Phthalate diesters /
- Prolactin /
- Testosterone /
- Estradiol /
- Male reproduction

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An Association of Elevated Serum Prolactin with Phthalate Exposure in Adult Men

doi: 10.3967/0895-3988.2011.01.004

基金项目: the Shanghai Municipal Health Bureau(08GWQ003)%the Shanghai Population and Family Planning Commission(2007JG05)

刊出日期: 2011-02-20

关键词:

Phthalate diesters /

Prolactin /

Testosterone /

Estradiol /

Male reproduction

摘要: Objective To investigate the associations of hormone circulation with phthalate exposure in adult men.Methods Semen and serum samples were collected from 118 men who were suspected of infertility.Phthalate diesters including dibutyl phthalate (DBP) and diethylhexyl phthalate (DEHP) in both semen and serum samples were measured, along with serum levels of follicle stimulating hormone (FSH),luteinizing hormone (LH), testosterone (T), estradiol (E2) and prolactin (PRL).Results Serum PRL was positively associated with serum DBP and DEHP and semen DEHP in all models of Spearman correlation, linear regression and binary logistic regression. In linear regression models adjusted for potential confounders and excluding subjects with undetectable phthalates, a 10-fold increase in semen DEHP was associated with a 23% increase in serum PRL, as well as a 26% increase in serum DBP and a 20% increase in serum DEHP. In logistic regression models all subjects demonstrated a dose-response relationship between above reference value PRL and semen DEHP (odds ratio per tertile adjusted for potential confounders = 1.0, 1.70, 3.50; Pfor trend = 0.01), and serum DBP (1.0, 1.10, 2.62;P for trend = 0.04), and serum DEHP (1.0, 1.46, 4.69; P for trend ＜ 0.01). A positive correlation between serum estradiol and semen DEHP (linear regression), and an inverse correlation between semen DBP and serum testosterone and T:E2 ratio (Spearman correlation) were also established.Conclusions Serum PRL is suggested to be positively associated with both DBP and DEHP exposure in adult men.

English Abstract

An Association of Elevated Serum Prolactin with Phthalate Exposure in Adult Men

School of Public Health, Fudan University, Shanghai 200032, China

Department of Urology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200001, China

Tongji University Medical School, Shanghai 200092, China

Funds: the Shanghai Municipal Health Bureau(08GWQ003)%the Shanghai Population and Family Planning Commission(2007JG05)

Publish Date: 2011-02-20

Keywords:

Abstract: Objective To investigate the associations of hormone circulation with phthalate exposure in adult men.Methods Semen and serum samples were collected from 118 men who were suspected of infertility.Phthalate diesters including dibutyl phthalate (DBP) and diethylhexyl phthalate (DEHP) in both semen and serum samples were measured, along with serum levels of follicle stimulating hormone (FSH),luteinizing hormone (LH), testosterone (T), estradiol (E2) and prolactin (PRL).Results Serum PRL was positively associated with serum DBP and DEHP and semen DEHP in all models of Spearman correlation, linear regression and binary logistic regression. In linear regression models adjusted for potential confounders and excluding subjects with undetectable phthalates, a 10-fold increase in semen DEHP was associated with a 23% increase in serum PRL, as well as a 26% increase in serum DBP and a 20% increase in serum DEHP. In logistic regression models all subjects demonstrated a dose-response relationship between above reference value PRL and semen DEHP (odds ratio per tertile adjusted for potential confounders = 1.0, 1.70, 3.50; Pfor trend = 0.01), and serum DBP (1.0, 1.10, 2.62;P for trend = 0.04), and serum DEHP (1.0, 1.46, 4.69; P for trend ＜ 0.01). A positive correlation between serum estradiol and semen DEHP (linear regression), and an inverse correlation between semen DBP and serum testosterone and T:E2 ratio (Spearman correlation) were also established.Conclusions Serum PRL is suggested to be positively associated with both DBP and DEHP exposure in adult men.

Citation: