JIANG Feng; LI Qing; HU Cheng; ZHANG Rong; WANG Cong Rong; YU Wei Hui; LU Jing Yi; TANG Shan Shan; BAO Yu Qian; XIANG Kun San; JIA Wei Ping

doi:10.3967/0895-3988.2012.01.004

doi: 10.3967/0895-3988.2012.01.004

基金项目: This work was funded by National 863 Program(2006AA02A409)%major program of Shanghai Municipality for Basic Research(08dj1400601)%"Chen Guang" Project(09CG07)

Association of a SLC30A8 Genetic Variant with Monotherapy of Repaglinide and Rosiglitazone Effect in Newly Diagnosed Type 2 Diabetes Patients in China

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital,Shanghai 200233,China; Shanghai Diabetes Institute, Shanghai 200233, China;Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China; Shanghai Clinical Center for Diabetes, Shanghai 200233, China
Shanghai Diabetes Institute, Shanghai 200233, China;Shanghai Key Laboratory of Diabetes Mellitus,Shanghai 200233, China;Shanghai Clinical Center for Diabetes, Shanghai 200233, China

Funds: This work was funded by National 863 Program(2006AA02A409)%major program of Shanghai Municipality for Basic Research(08dj1400601)%"Chen Guang" Project(09CG07)

摘要: Objective To investigate a potential relationship between Solute carrier family 30 (zinc transporter)member 8 (SLC30A8) rs13266634 variant and efficacy of rosiglitazone or repaglinide in treating newly diagnosed Chinese type 2 diabetes patients.Methods A total of 209 diabetic patients without any antihyperglycemic history were recruited and treated with repaglinide or rosiglitazone randomly for 48 weeks (104 and 105 patients,respectively).Anthropometric measurements and clinical laboratory tests were carried out before and after the treatment.An non-synonymous variant rs13266634 was genotyped by matrix-assisted laser desorption ionization-time of flight mass spectroscopy.Results Ninety-one patients in repaglinide group and ninety-three patients in rosiglitazone group completed the study.A value of homeostasis model assessment of beta cell function (HOMA-B) and A value of fasting proinsulin levels were statistically significant between three genotype groups (P=0.0149and 0.0246,respectively) after rosiglitazone treatment.However,no genotype association was observed in the repaglinide or rosiglitazone group with other parameters.Conclusion The SLC30A8 variant was associated with the efficacy of insulin sensitizer monotherapy on insulin secretion in patients with newly diagnosed type 2 diabetes mellitus in Shanghai,China.
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Abstract: Objective To investigate a potential relationship between Solute carrier family 30 (zinc transporter)member 8 (SLC30A8) rs13266634 variant and efficacy of rosiglitazone or repaglinide in treating newly diagnosed Chinese type 2 diabetes patients.Methods A total of 209 diabetic patients without any antihyperglycemic history were recruited and treated with repaglinide or rosiglitazone randomly for 48 weeks (104 and 105 patients,respectively).Anthropometric measurements and clinical laboratory tests were carried out before and after the treatment.An non-synonymous variant rs13266634 was genotyped by matrix-assisted laser desorption ionization-time of flight mass spectroscopy.Results Ninety-one patients in repaglinide group and ninety-three patients in rosiglitazone group completed the study.A value of homeostasis model assessment of beta cell function (HOMA-B) and A value of fasting proinsulin levels were statistically significant between three genotype groups (P=0.0149and 0.0246,respectively) after rosiglitazone treatment.However,no genotype association was observed in the repaglinide or rosiglitazone group with other parameters.Conclusion The SLC30A8 variant was associated with the efficacy of insulin sensitizer monotherapy on insulin secretion in patients with newly diagnosed type 2 diabetes mellitus in Shanghai,China.
- Pharmacogenetics /
- Single nucleotide polymorphisms /
- Solute carrier family 30 member 8 /
- SLC30A8

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doi: 10.3967/0895-3988.2012.01.004

Association of a SLC30A8 Genetic Variant with Monotherapy of Repaglinide and Rosiglitazone Effect in Newly Diagnosed Type 2 Diabetes Patients in China

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Association of a SLC30A8 Genetic Variant with Monotherapy of Repaglinide and Rosiglitazone Effect in Newly Diagnosed Type 2 Diabetes Patients in China

doi: 10.3967/0895-3988.2012.01.004

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Association of a SLC30A8 Genetic Variant with Monotherapy of Repaglinide and Rosiglitazone Effect in Newly Diagnosed Type 2 Diabetes Patients in China

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doi: 10.3967/0895-3988.2012.01.004

Association of a SLC30A8 Genetic Variant with Monotherapy of Repaglinide and Rosiglitazone Effect in Newly Diagnosed Type 2 Diabetes Patients in China

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Association of a SLC30A8 Genetic Variant with Monotherapy of Repaglinide and Rosiglitazone Effect in Newly Diagnosed Type 2 Diabetes Patients in China

doi: 10.3967/0895-3988.2012.01.004

English Abstract

Association of a SLC30A8 Genetic Variant with Monotherapy of Repaglinide and Rosiglitazone Effect in Newly Diagnosed Type 2 Diabetes Patients in China

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